Human Gene FAR1 (ENST00000354817.8_4) from GENCODE V47lift37
  Description: fatty acyl-CoA reductase 1 (from RefSeq NM_032228.6)
Gencode Transcript: ENST00000354817.8_4
Gencode Gene: ENSG00000197601.15_11
Transcript (Including UTRs)
   Position: hg19 chr11:13,690,215-13,753,893 Size: 63,679 Total Exon Count: 12 Strand: +
Coding Region
   Position: hg19 chr11:13,716,313-13,750,321 Size: 34,009 Coding Exon Count: 11 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr11:13,690,215-13,753,893)mRNA (may differ from genome)Protein (515 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsHGNC
MalacardsMGIOMIMPubMedReactomeUniProtKB
WikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: FACR1_HUMAN
DESCRIPTION: RecName: Full=Fatty acyl-CoA reductase 1; EC=1.2.1.n2; AltName: Full=Male sterility domain-containing protein 2;
FUNCTION: Catalyzes the reduction of saturated fatty acyl-CoA with chain length C16 or C18 to fatty alcohols.
CATALYTIC ACTIVITY: Hexadecanal + CoA + NADP(+) = hexadecanoyl-CoA + NADPH.
INTERACTION: Q9BUV8:C20orf24; NbExp=1; IntAct=EBI-1045879, EBI-1050079;
SUBCELLULAR LOCATION: Peroxisome membrane; Single-pass membrane protein (Potential).
SIMILARITY: Belongs to the fatty acyl-CoA reductase family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: FAR1
Diseases sorted by gene-association score: peroxisomal fatty acyl-coa reductase 1 disorder* (1581), rhizomelic chondrodysplasia punctata, type 5 (12), spasticity (8), rhizomelic chondrodysplasia punctata, type 2 (7), rhizomelic chondrodysplasia punctata, type 1 (6), intellectual disability (6), ceroid lipofuscinosis, neuronal, 1 (5), microcephaly (3)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 27.03 RPKM in Brain - Spinal cord (cervical c-1)
Total median expression: 611.24 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -66.50146-0.455 Picture PostScript Text
3' UTR -823.603572-0.231 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR026055 - FAR
IPR013120 - Male_sterile_NAD-bd
IPR016040 - NAD(P)-bd_dom

Pfam Domains:
PF01370 - NAD dependent epimerase/dehydratase family
PF03015 - Male sterility protein
PF07993 - Male sterility protein

SCOP Domains:
51735 - NAD(P)-binding Rossmann-fold domains

ModBase Predicted Comparative 3D Structure on Q8WVX9
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0016491 oxidoreductase activity
GO:0080019 fatty-acyl-CoA reductase (alcohol-forming) activity

Biological Process:
GO:0006629 lipid metabolic process
GO:0008611 ether lipid biosynthetic process
GO:0010025 wax biosynthetic process
GO:0035336 long-chain fatty-acyl-CoA metabolic process
GO:0046474 glycerophospholipid biosynthetic process
GO:0055114 oxidation-reduction process

Cellular Component:
GO:0005777 peroxisome
GO:0005778 peroxisomal membrane
GO:0005779 integral component of peroxisomal membrane
GO:0005782 peroxisomal matrix
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  LP895216 - Sequence 80 from Patent EP3253886.
AY358784 - Homo sapiens clone DNA94849 VSIP2423 (UNQ2423) mRNA, complete cds.
LF207857 - JP 2014500723-A/15360: Polycomb-Associated Non-Coding RNAs.
CR936619 - Homo sapiens mRNA; cDNA DKFZp686A0370 (from clone DKFZp686A0370).
AK315527 - Homo sapiens cDNA, FLJ96593.
AK026381 - Homo sapiens cDNA: FLJ22728 fis, clone HSI15617.
JD343353 - Sequence 324377 from Patent EP1572962.
AY423606 - Homo sapiens putative fatty acyl reductase mRNA, complete cds.
BC017377 - Homo sapiens fatty acyl CoA reductase 1, mRNA (cDNA clone MGC:16299 IMAGE:3835094), complete cds.
AY600449 - Homo sapiens fatty acyl CoA reductase 1 (FAR1) mRNA, complete cds.
JD272734 - Sequence 253758 from Patent EP1572962.
JD157760 - Sequence 138784 from Patent EP1572962.
LF207858 - JP 2014500723-A/15361: Polycomb-Associated Non-Coding RNAs.
KJ904913 - Synthetic construct Homo sapiens clone ccsbBroadEn_14307 FAR1-like gene, encodes complete protein.
LF369546 - JP 2014500723-A/177049: Polycomb-Associated Non-Coding RNAs.
LF369547 - JP 2014500723-A/177050: Polycomb-Associated Non-Coding RNAs.
LF369548 - JP 2014500723-A/177051: Polycomb-Associated Non-Coding RNAs.
LF369552 - JP 2014500723-A/177055: Polycomb-Associated Non-Coding RNAs.
LF369557 - JP 2014500723-A/177060: Polycomb-Associated Non-Coding RNAs.
BX648892 - Homo sapiens mRNA; cDNA DKFZp686P18247 (from clone DKFZp686P18247).
AK090880 - Homo sapiens cDNA FLJ33561 fis, clone BRAMY2009693, highly similar to Torpedo marmorata mRNA for male sterility protein 2-like protein.
AX746662 - Sequence 187 from Patent EP1308459.
LF369561 - JP 2014500723-A/177064: Polycomb-Associated Non-Coding RNAs.
LF369565 - JP 2014500723-A/177068: Polycomb-Associated Non-Coding RNAs.
LF369567 - JP 2014500723-A/177070: Polycomb-Associated Non-Coding RNAs.
LF369568 - JP 2014500723-A/177071: Polycomb-Associated Non-Coding RNAs.
JD331557 - Sequence 312581 from Patent EP1572962.
JD059298 - Sequence 40322 from Patent EP1572962.
LF369569 - JP 2014500723-A/177072: Polycomb-Associated Non-Coding RNAs.
LF369570 - JP 2014500723-A/177073: Polycomb-Associated Non-Coding RNAs.
LF369571 - JP 2014500723-A/177074: Polycomb-Associated Non-Coding RNAs.
AK024967 - Homo sapiens cDNA: FLJ21314 fis, clone COL02248.
LF369572 - JP 2014500723-A/177075: Polycomb-Associated Non-Coding RNAs.
AF086349 - Homo sapiens full length insert cDNA clone ZD62G02.
LF369573 - JP 2014500723-A/177076: Polycomb-Associated Non-Coding RNAs.
LF369574 - JP 2014500723-A/177077: Polycomb-Associated Non-Coding RNAs.
AL713674 - Homo sapiens mRNA; cDNA DKFZp761I1913 (from clone DKFZp761I1913).
MA605123 - JP 2018138019-A/177049: Polycomb-Associated Non-Coding RNAs.
MA605124 - JP 2018138019-A/177050: Polycomb-Associated Non-Coding RNAs.
MA605125 - JP 2018138019-A/177051: Polycomb-Associated Non-Coding RNAs.
MA605129 - JP 2018138019-A/177055: Polycomb-Associated Non-Coding RNAs.
MA605134 - JP 2018138019-A/177060: Polycomb-Associated Non-Coding RNAs.
MA605138 - JP 2018138019-A/177064: Polycomb-Associated Non-Coding RNAs.
MA605142 - JP 2018138019-A/177068: Polycomb-Associated Non-Coding RNAs.
MA605144 - JP 2018138019-A/177070: Polycomb-Associated Non-Coding RNAs.
MA605145 - JP 2018138019-A/177071: Polycomb-Associated Non-Coding RNAs.
MA605146 - JP 2018138019-A/177072: Polycomb-Associated Non-Coding RNAs.
MA605147 - JP 2018138019-A/177073: Polycomb-Associated Non-Coding RNAs.
MA605148 - JP 2018138019-A/177074: Polycomb-Associated Non-Coding RNAs.
MA605149 - JP 2018138019-A/177075: Polycomb-Associated Non-Coding RNAs.
MA605150 - JP 2018138019-A/177076: Polycomb-Associated Non-Coding RNAs.
MA605151 - JP 2018138019-A/177077: Polycomb-Associated Non-Coding RNAs.
MA443434 - JP 2018138019-A/15360: Polycomb-Associated Non-Coding RNAs.
MA443435 - JP 2018138019-A/15361: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  BioCyc Knowledge Library
PWY-7782 - plasmalogen biosynthesis

Reactome (by CSHL, EBI, and GO)

Protein Q8WVX9 (Reactome details) participates in the following event(s):

R-HSA-390425 FAR1 reduces PalmCoA to HXOL
R-HSA-8848584 Wax biosynthesis
R-HSA-556833 Metabolism of lipids
R-HSA-1430728 Metabolism

-  Other Names for This Gene
  Alternate Gene Symbols: D3DQW8, ENST00000354817.1, ENST00000354817.2, ENST00000354817.3, ENST00000354817.4, ENST00000354817.5, ENST00000354817.6, ENST00000354817.7, FACR1_HUMAN, FAR1 , MLSTD2 , NM_032228, Q5CZA3, Q8WVX9, uc317yun.1, uc317yun.2, UNQ2423/PRO4981
UCSC ID: ENST00000354817.8_4
RefSeq Accession: NM_032228.6
Protein: Q8WVX9 (aka FACR1_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.