Human Gene FASLG (ENST00000367721.3_4) from GENCODE V47lift37
  Description: Fas ligand, transcript variant 1 (from RefSeq NM_000639.3)
Gencode Transcript: ENST00000367721.3_4
Gencode Gene: ENSG00000117560.8_8
Transcript (Including UTRs)
   Position: hg19 chr1:172,628,243-172,636,016 Size: 7,774 Total Exon Count: 4 Strand: +
Coding Region
   Position: hg19 chr1:172,628,342-172,635,156 Size: 6,815 Coding Exon Count: 4 

Page IndexSequence and LinksPrimersMalaCardsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesGeneReviewsModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:172,628,243-172,636,016)mRNA (may differ from genome)Protein (281 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedReactome
UniProtKBWikipediaBioGrid CRISPR DB

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: FASLG
Diseases sorted by gene-association score: autoimmune lymphoproliferative syndrome* (1705), faslg-related autoimmune lymphoproliferative syndrome* (200), lung cancer* (167), silicosis (29), lymphoproliferative syndrome (24), hypersensitivity syndrome, carbamazepine-induced (18), t-cell large granular lymphocyte leukemia (16), chronic inflammatory demyelinating polyneuritis (15), hashimoto thyroiditis (11), chronic venous leg ulcers (10), lymphocytic gastritis (10), breast medullary carcinoma (10), erythema multiforme (10), myelopathy, htlv-1-associated (10), chediak-higashi syndrome (10), pneumoconiosis (9), lymphopenia (9), autoimmune lymphoproliferative syndrome, type iii (8), brain glioma (8), viral hepatitis (8), lymphomatoid papulosis (8), sjogren's syndrome (8), cartilage-hair hypoplasia (8), nontoxic goiter (8), thyroiditis (8), type ii mixed cryoglobulinemia (7), acute graft versus host disease (7), graves' disease (7), acute t cell leukemia (7), acute myocarditis (7), hepatitis (6), alopecia areata (6), epstein-barr virus-associated gastric carcinoma (6), fuchs' endothelial dystrophy (6), bile duct carcinoma (6), lymphadenitis (5), hepatocellular carcinoma (5), photokeratitis (5), systemic lupus erythematosus (5), choriocarcinoma of the testis (5), idiopathic neutropenia (5), colorectal cancer (5), chronic nk-cell lymphocytosis (4), chorioretinal scar (4), neutropenia (4), acute hemorrhagic leukoencephalitis (4), sialolithiasis (4), central nervous system tuberculosis (4), stomach cancer (4), malignant glioma (4), granulomatous hepatitis (4), b-cell expansion with nfkb and t-cell anergy (4), aplastic anemia (3), esophageal cancer (3), ovarian cancer, somatic (2), eye disease (2), malaria (1), pulmonary fibrosis, idiopathic (1), diabetes mellitus, insulin-dependent (1)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 2.61 RPKM in Spleen
Total median expression: 7.18 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -30.1099-0.304 Picture PostScript Text
3' UTR -237.90860-0.277 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR008064 - Fas_ligand
IPR006052 - TNF
IPR006053 - TNF_a/b/c
IPR021184 - TNF_CS
IPR008983 - Tumour_necrosis_fac-like

Pfam Domains:
PF00229 - TNF(Tumour Necrosis Factor) family

SCOP Domains:
49842 - TNF-like

ModBase Predicted Comparative 3D Structure on Q53ZZ1
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGDEnsembl   
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005123 death receptor binding
GO:0005125 cytokine activity
GO:0005164 tumor necrosis factor receptor binding

Biological Process:
GO:0006915 apoptotic process
GO:0006925 inflammatory cell apoptotic process
GO:0006955 immune response
GO:0008284 positive regulation of cell proliferation
GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors
GO:0010469 regulation of receptor activity
GO:0030644 cellular chloride ion homeostasis
GO:0032496 response to lipopolysaccharide
GO:0033209 tumor necrosis factor-mediated signaling pathway
GO:0043525 positive regulation of neuron apoptotic process
GO:0045742 positive regulation of epidermal growth factor receptor signaling pathway
GO:0046666 retinal cell programmed cell death
GO:0048388 endosomal lumen acidification
GO:0070848 response to growth factor
GO:0097190 apoptotic signaling pathway

Cellular Component:
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005886 plasma membrane
GO:0005901 caveola
GO:0009897 external side of plasma membrane
GO:0009986 cell surface
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0031410 cytoplasmic vesicle
GO:0045121 membrane raft
GO:0048471 perinuclear region of cytoplasm


-  Descriptions from all associated GenBank mRNAs
  D38122 - Homo sapiens mRNA for Fas ligand, complete cds.
E11157 - cDNA encoding human Fas ligand.
AK314874 - Homo sapiens cDNA, FLJ95775, Homo sapiens tumor necrosis factor (ligand) superfamily, member 6(TNFSF6), mRNA.
HI635191 - Sequence 41038 from Patent EP2242854.
HV708946 - JP 2012506450-A/44: Methods for treating eye disorders.
JA482178 - Sequence 161 from Patent WO2011072091.
JE980470 - Sequence 161 from Patent EP2862929.
KJ948655 - Homo sapiens mutant tumor necrosis factor family member 6 (FASLG) mRNA, complete cds.
X89102 - H.sapiens mRNA for fasligand.
BC017502 - Homo sapiens Fas ligand (TNF superfamily, member 6), mRNA (cDNA clone MGC:23109 IMAGE:4849770), complete cds.
JD077865 - Sequence 58889 from Patent EP1572962.
U08137 - Human Fas ligand mRNA, complete cds.
E11354 - Human cDNA encoding Fas antigen binding protein.
AF288573 - Homo sapiens FasL isoform mRNA, complete cds.
U11821 - Human Fas ligand (FasL) mRNA, complete cds.
AB528416 - Synthetic construct DNA, clone: pF1KB6314, Homo sapiens FASLG gene for Fas ligand, without stop codon, in Flexi system.
DQ896147 - Synthetic construct Homo sapiens clone IMAGE:100010607; FLH193394.01L; RZPDo839F1068D Fas ligand (TNF superfamily, member 6) (FASLG) gene, encodes complete protein.
DQ893466 - Synthetic construct clone IMAGE:100006096; FLH193398.01X; RZPDo839F1078D Fas ligand (TNF superfamily, member 6) (FASLG) gene, encodes complete protein.
CU675998 - Synthetic construct Homo sapiens gateway clone IMAGE:100023387 5' read FASLG mRNA.
KJ890694 - Synthetic construct Homo sapiens clone ccsbBroadEn_00088 FASLG gene, encodes complete protein.
KR710526 - Synthetic construct Homo sapiens clone CCSBHm_00013802 FASLG (FASLG) mRNA, encodes complete protein.
E11156 - cDNA encoding human Fas ligand.
E11347 - Human cDNA encoding Fas antigen binding protein.
AY225406 - Homo sapiens FAS ligand (TNFSF6) mRNA, complete cds.
AY858799 - Homo sapiens CD95 ligand (FASLG) mRNA, complete cds.
JD056227 - Sequence 37251 from Patent EP1572962.
E11350 - Human cDNA encoding Fas antigen binding protein.
JD440482 - Sequence 421506 from Patent EP1572962.
JD112774 - Sequence 93798 from Patent EP1572962.
JD374484 - Sequence 355508 from Patent EP1572962.
JD354209 - Sequence 335233 from Patent EP1572962.
JD086830 - Sequence 67854 from Patent EP1572962.
JD269237 - Sequence 250261 from Patent EP1572962.
JD188486 - Sequence 169510 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  BioCarta from NCI Cancer Genome Anatomy Project
h_ctlPathway - CTL mediated immune response against target cells
h_pmlPathway - Regulation of transcriptional activity by PML
h_achPathway - Role of nicotinic acetylcholine receptors in the regulation of apoptosis
h_asbcellPathway - Antigen Dependent B Cell Activation
h_bbcellPathway - Bystander B Cell Activation
h_fasPathway - FAS signaling pathway ( CD95 )
h_hsp27Pathway - Stress Induction of HSP Regulation
h_keratinocytePathway - Keratinocyte Differentiation
h_tcapoptosisPathway - HIV Induced T Cell Apoptosis
h_HivnefPathway - HIV-I Nef: negative effector of Fas and TNF
h_aktPathway - AKT Signaling Pathway
h_il2rbPathway - IL-2 Receptor Beta Chain in T cell Activation
h_ptenPathway - PTEN dependent cell cycle arrest and apoptosis

Reactome (by CSHL, EBI, and GO)

Protein Q53ZZ1 (Reactome details) participates in the following event(s):

R-HSA-5675948 TNFRSF6B binds TNFSF6,14,15
R-HSA-5669034 TNFs bind their physiological receptors
R-HSA-5668541 TNFR2 non-canonical NF-kB pathway
R-HSA-1280215 Cytokine Signaling in Immune system
R-HSA-168256 Immune System

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000367721.1, ENST00000367721.2, FASLG , hCG_37643 , NM_000639, Q53ZZ1, Q53ZZ1_HUMAN, TNFSF6 , TNLG1A , uc318gdl.1, uc318gdl.2
UCSC ID: ENST00000367721.3_4
RefSeq Accession: NM_000639.3
Protein: Q53ZZ1

-  GeneReviews for This Gene
  GeneReviews article(s) related to gene FASLG:
alps (Autoimmune Lymphoproliferative Syndrome)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.