ID:FXL15_HUMAN DESCRIPTION: RecName: Full=F-box/LRR-repeat protein 15; AltName: Full=F-box only protein 37; FUNCTION: Substrate recognition component of a (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of SMURF1, thereby acting as a positive regulator of the BMP signaling pathway. Required for dorsal/ventral pattern formation and bone mass maintenance. Also mediates ubiquitination of SMURF2 and WWP2. PATHWAY: Protein modification; protein ubiquitination. SUBUNIT: Part of the SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complex SCF(FBXL15) composed of CUL1, SKP1, RBX1 and FBXL15. SUBCELLULAR LOCATION: Cytoplasm. SIMILARITY: Belongs to the FBXL15 family. SIMILARITY: Contains 1 F-box domain. SIMILARITY: Contains 5 LRR (leucine-rich) repeats. SEQUENCE CAUTION: Sequence=AAH02912.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAH36120.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=CAI12517.1; Type=Erroneous gene model prediction; Sequence=CAI12518.1; Type=Erroneous gene model prediction; Sequence=CAI12519.1; Type=Erroneous gene model prediction; Sequence=CAI12520.1; Type=Erroneous gene model prediction; Sequence=CAI12522.2; Type=Erroneous initiation; Note=Translation N-terminally extended;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9H469
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0004842 ubiquitin-protein transferase activity GO:0005515 protein binding
Biological Process: GO:0000086 G2/M transition of mitotic cell cycle GO:0000209 protein polyubiquitination GO:0009953 dorsal/ventral pattern formation GO:0016567 protein ubiquitination GO:0030282 bone mineralization GO:0030513 positive regulation of BMP signaling pathway GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0043687 post-translational protein modification
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
