ID:FBX7_HUMAN DESCRIPTION: RecName: Full=F-box only protein 7; FUNCTION: Substrate recognition component of a (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes BIRC2 and DLGAP5. PATHWAY: Protein modification; protein ubiquitination. SUBUNIT: Part of the SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complex SCF(FBXO7) formed of CUL1, SKP1, RBX1 and FBXO7. Interacts via its C-terminal proline-rich region with DLGAP5. Interacts with BIRC2. Interacts with CDK6 and promotes its interaction with D-type cyclin. INTERACTION: P63208:SKP1; NbExp=2; IntAct=EBI-1161222, EBI-307486; SUBCELLULAR LOCATION: Cytoplasm. Nucleus. DISEASE: Defects in FBXO7 are the cause of Parkinson disease type 15 (PARK15) [MIM:260300]; also known as parkinsonian-pyramidal syndrome. A neurodegenerative disorder characterized by parkinsonian and pyramidal signs. Clinical manifestations include tremor, bradykinesia, rigidity, postural instability, spasticity, mainly in the lower limbs, and hyperreflexia. SIMILARITY: Contains 1 F-box domain. SEQUENCE CAUTION: Sequence=AAF04471.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9Y3I1
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0004842 ubiquitin-protein transferase activity GO:0005515 protein binding GO:0019901 protein kinase binding GO:0031625 ubiquitin protein ligase binding GO:0043130 ubiquitin binding GO:0046982 protein heterodimerization activity
Biological Process: GO:0000209 protein polyubiquitination GO:0000422 mitophagy GO:0006511 ubiquitin-dependent protein catabolic process GO:0006626 protein targeting to mitochondrion GO:0010975 regulation of neuron projection development GO:0016567 protein ubiquitination GO:0031647 regulation of protein stability GO:0040012 regulation of locomotion GO:0043687 post-translational protein modification GO:0045620 negative regulation of lymphocyte differentiation GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity GO:1901215 negative regulation of neuron death GO:1903204 negative regulation of oxidative stress-induced neuron death GO:1903208 negative regulation of hydrogen peroxide-induced neuron death GO:1903599 positive regulation of mitophagy GO:2000134 negative regulation of G1/S transition of mitotic cell cycle
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
