Human Gene FBXW11 (ENST00000517395.6_10) from GENCODE V47lift37
  Description: F-box and WD repeat domain containing 11, transcript variant 6 (from RefSeq NM_001378976.1)
Gencode Transcript: ENST00000517395.6_10
Gencode Gene: ENSG00000072803.18_14
Transcript (Including UTRs)
   Position: hg19 chr5:171,288,553-171,433,642 Size: 145,090 Total Exon Count: 14 Strand: -
Coding Region
   Position: hg19 chr5:171,295,639-171,433,506 Size: 137,868 Coding Exon Count: 13 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr5:171,288,553-171,433,642)mRNA (may differ from genome)Protein (563 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
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HGNCMGIOMIMPubMedUniProtKBWikipedia
BioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: E5RGC1_HUMAN
DESCRIPTION: SubName: Full=F-box/WD repeat-containing protein 11; Flags: Fragment;
SIMILARITY: Contains 1 F-box domain.
CAUTION: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 22.35 RPKM in Brain - Cerebellar Hemisphere
Total median expression: 634.48 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -91.20136-0.671 Picture PostScript Text
3' UTR -703.902578-0.273 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR021977 - Beta-TrCP_D
IPR001810 - F-box_dom_cyclin-like

Pfam Domains:
PF00400 - WD domain, G-beta repeat
PF00646 - F-box domain
PF12125 - D domain of beta-TrCP
PF12937 - F-box-like

SCOP Domains:
81383 - F-box domain
50952 - Soluble quinoprotein glucose dehydrogenase
50956 - Thermostable phytase (3-phytase)
50960 - TolB, C-terminal domain
63825 - YWTD domain
63829 - Calcium-dependent phosphotriesterase
69304 - Tricorn protease N-terminal domain
101898 - NHL repeat
50965 - Galactose oxidase, central domain
75011 - 3-carboxy-cis,cis-mucoante lactonizing enzyme
101908 - Putative isomerase YbhE
117289 - Nucleoporin domain
50969 - YVTN repeat-like/Quinoprotein amine dehydrogenase
50974 - Nitrous oxide reductase, N-terminal domain
50978 - WD40 repeat-like
50993 - Peptidase/esterase 'gauge' domain
69322 - Tricorn protease domain 2
50998 - Quinoprotein alcohol dehydrogenase-like
51004 - C-terminal (heme d1) domain of cytochrome cd1-nitrite reductase
82171 - DPP6 N-terminal domain-like
51182 - RmlC-like cupins
51294 - Hedgehog/intein (Hint) domain

ModBase Predicted Comparative 3D Structure on E5RGC1
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0046983 protein dimerization activity


-  Descriptions from all associated GenBank mRNAs
  AB014596 - Homo sapiens KIAA0696 mRNA for KIAA0696 protein.
BC026213 - Homo sapiens F-box and WD repeat domain containing 11, mRNA (cDNA clone MGC:21122 IMAGE:4419029), complete cds.
AB033279 - Homo sapiens BTRCP2 mRNA for F-box and WD-repeats protein beta-TRCP2 isoform A, complete cds.
AB033281 - Homo sapiens BTRCP2 mRNA for F-box and WD-repeats protein isoform C, complete cds.
AB033280 - Homo sapiens BTRCP2 mRNA for F-box and WD-repeats protein beta-TRCP2 isoform B, complete cds.
AK294956 - Homo sapiens cDNA FLJ54601 complete cds, highly similar to F-box/WD repeat protein 11.
AK314999 - Homo sapiens cDNA, FLJ95926, highly similar to Homo sapiens F-box and WD-40 domain protein 1B (FBXW1B), transcriptvariant 1, mRNA.
AF176022 - Homo sapiens F-box protein Fbw1b (FBW1B) mRNA, complete cds.
AB383960 - Synthetic construct DNA, clone: pF1KSDA0696, Homo sapiens FBXW11 gene for F-box/WD repeat protein 11, complete cds, without stop codon, in Flexi system.
DQ891125 - Synthetic construct clone IMAGE:100003755; FLH169534.01X; RZPDo839D0596D F-box and WD-40 domain protein 11 (FBXW11) gene, encodes complete protein.
KJ893352 - Synthetic construct Homo sapiens clone ccsbBroadEn_02746 FBXW11 gene, encodes complete protein.
DQ894304 - Synthetic construct Homo sapiens clone IMAGE:100008764; FLH169530.01L; RZPDo839D0595D F-box and WD-40 domain protein 11 (FBXW11) gene, encodes complete protein.
JD167523 - Sequence 148547 from Patent EP1572962.
JD509485 - Sequence 490509 from Patent EP1572962.
JD279481 - Sequence 260505 from Patent EP1572962.
JD311054 - Sequence 292078 from Patent EP1572962.
JD082244 - Sequence 63268 from Patent EP1572962.
JD393384 - Sequence 374408 from Patent EP1572962.
JD172054 - Sequence 153078 from Patent EP1572962.
JD550398 - Sequence 531422 from Patent EP1572962.
JD371899 - Sequence 352923 from Patent EP1572962.
JD069569 - Sequence 50593 from Patent EP1572962.
JD231134 - Sequence 212158 from Patent EP1572962.
JD457818 - Sequence 438842 from Patent EP1572962.
JD540614 - Sequence 521638 from Patent EP1572962.
JD560173 - Sequence 541197 from Patent EP1572962.
JD288461 - Sequence 269485 from Patent EP1572962.
JD480679 - Sequence 461703 from Patent EP1572962.
JD558037 - Sequence 539061 from Patent EP1572962.
JD099514 - Sequence 80538 from Patent EP1572962.
JD506904 - Sequence 487928 from Patent EP1572962.
JD480270 - Sequence 461294 from Patent EP1572962.
JD541143 - Sequence 522167 from Patent EP1572962.
JD123010 - Sequence 104034 from Patent EP1572962.
JD273853 - Sequence 254877 from Patent EP1572962.
JD327138 - Sequence 308162 from Patent EP1572962.
JD102671 - Sequence 83695 from Patent EP1572962.
JD438761 - Sequence 419785 from Patent EP1572962.
JD289424 - Sequence 270448 from Patent EP1572962.
JD181926 - Sequence 162950 from Patent EP1572962.
JD408736 - Sequence 389760 from Patent EP1572962.
JD396583 - Sequence 377607 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: E5RGC1, E5RGC1_HUMAN, ENST00000517395.1, ENST00000517395.2, ENST00000517395.3, ENST00000517395.4, ENST00000517395.5, FBXW11 , NM_001378976, uc323plc.1, uc323plc.2
UCSC ID: ENST00000517395.6_10
RefSeq Accession: NM_001378974.1
Protein: E5RGC1

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.