Human Gene FCER2 (ENST00000597921.6_9) from GENCODE V47lift37
  Description: Fc epsilon receptor II, transcript variant 1 (from RefSeq NM_002002.5)
Gencode Transcript: ENST00000597921.6_9
Gencode Gene: ENSG00000104921.15_12
Transcript (Including UTRs)
   Position: hg19 chr19:7,753,662-7,767,017 Size: 13,356 Total Exon Count: 11 Strand: -
Coding Region
   Position: hg19 chr19:7,754,079-7,764,646 Size: 10,568 Coding Exon Count: 10 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr19:7,753,662-7,767,017)mRNA (may differ from genome)Protein (321 aa)
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-  Comments and Description Text from UniProtKB
  ID: FCER2_HUMAN
DESCRIPTION: RecName: Full=Low affinity immunoglobulin epsilon Fc receptor; AltName: Full=BLAST-2; AltName: Full=C-type lectin domain family 4 member J; AltName: Full=Fc-epsilon-RII; AltName: Full=Immunoglobulin E-binding factor; AltName: Full=Lymphocyte IgE receptor; AltName: CD_antigen=CD23; Contains: RecName: Full=Low affinity immunoglobulin epsilon Fc receptor membrane-bound form; Contains: RecName: Full=Low affinity immunoglobulin epsilon Fc receptor soluble form;
FUNCTION: Low-affinity receptor for immunoglobulin E (IgE) and CR2/CD21. Has essential roles in the regulation of IgE production and in the differentiation of B-cells (it is a B-cell-specific antigen).
SUBCELLULAR LOCATION: Cell membrane; Single-pass type II membrane protein. Secreted. Note=Also exists as a soluble excreted form.
PTM: N- and O-glycosylated.
MISCELLANEOUS: There are two kinds of Fc receptors for IgE, which differ in both structure and function: high affinity receptors on basophils and mast cells and low affinity receptors on lymphocytes and monocytes.
SIMILARITY: Contains 1 C-type lectin domain.
SEQUENCE CAUTION: Sequence=AAA52433.1; Type=Erroneous gene model prediction;
WEB RESOURCE: Name=Functional Glycomics Gateway - Glycan Binding; Note=CD23; URL="http://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_Ctlect_221";

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: FCER2
Diseases sorted by gene-association score: chronic conjunctivitis (21), chronic lymphocytic leukemia (13), follicular dendritic cell sarcoma (11), persistent polyclonal b-cell lymphocytosis (11), hereditary dystonia (9), reticulum cell sarcoma (9), cutaneous leishmaniasis (8), intrinsic asthma (7), prolymphocytic leukemia (7), dendritic cell tumor (7), allergic hypersensitivity disease (7), extrinsic allergic alveolitis (7), b-cell expansion with nfkb and t-cell anergy (6), urticaria (6), b cell prolymphocytic leukemia (6), toxic oil syndrome (6), atopic dermatitis (5), inflammatory bowel disease 6 (5), idiopathic neutropenia (5), atopy (3), dyskeratosis congenita (1), lymphoma, non-hodgkin (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 242.48 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 288.87 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -63.60202-0.315 Picture PostScript Text
3' UTR -112.20417-0.269 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001304 - C-type_lectin
IPR016186 - C-type_lectin-like
IPR018378 - C-type_lectin_CS
IPR016187 - C-type_lectin_fold

Pfam Domains:
PF00059 - Lectin C-type domain

SCOP Domains:
56436 - C-type lectin-like
75704 - Mitotic arrest deficient-like 1, Mad1

Protein Data Bank (PDB) 3-D Structure
MuPIT help
1HLI - Model 1KJE - Model 1T8C - NMR MuPIT 1T8D - NMR MuPIT 2H2R - X-ray MuPIT 2H2T - X-ray MuPIT 4EZM - X-ray MuPIT


ModBase Predicted Comparative 3D Structure on P06734
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005178 integrin binding
GO:0005515 protein binding
GO:0019863 IgE binding
GO:0030246 carbohydrate binding
GO:0046872 metal ion binding

Biological Process:
GO:0002925 positive regulation of humoral immune response mediated by circulating immunoglobulin
GO:0007219 Notch signaling pathway
GO:0019221 cytokine-mediated signaling pathway
GO:0051000 positive regulation of nitric-oxide synthase activity
GO:0051712 positive regulation of killing of cells of other organism
GO:0051770 positive regulation of nitric-oxide synthase biosynthetic process

Cellular Component:
GO:0005576 extracellular region
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0009897 external side of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0070062 extracellular exosome


-  Descriptions from all associated GenBank mRNAs
  LP896127 - Sequence 991 from Patent EP3253886.
BC062591 - Homo sapiens Fc fragment of IgE, low affinity II, receptor for (CD23), mRNA (cDNA clone MGC:74689 IMAGE:5216918), complete cds.
BC014108 - Homo sapiens Fc fragment of IgE, low affinity II, receptor for (CD23), mRNA (cDNA clone MGC:20696 IMAGE:4309266), complete cds.
E01646 - cDNA encoding Fc epsilon receptor.
M14766 - Human Fc-epsilon receptor CD23 antigen (IgE receptor) mRNA complete cds.
BC027879 - Homo sapiens Fc fragment of IgE, low affinity II, receptor for (CD23), mRNA (cDNA clone IMAGE:5207648), with apparent retained intron.
M15059 - Human Fc-epsilon receptor (IgE receptor) mRNA, complete cds (H107 epitope).
JD156534 - Sequence 137558 from Patent EP1572962.
AK223207 - Homo sapiens mRNA for Fc fragment of IgE, low affinity II, receptor for (CD23A) variant, clone: SPL03672.
X04772 - Human mRNA for lymphocyte IgE receptor (low affinity receptor Fc epsilon R).
BC064417 - Homo sapiens Fc fragment of IgE, low affinity II, receptor for (CD23), mRNA (cDNA clone IMAGE:5750404).
AK310071 - Homo sapiens cDNA, FLJ17113.
JD122616 - Sequence 103640 from Patent EP1572962.
JD149129 - Sequence 130153 from Patent EP1572962.
JD149128 - Sequence 130152 from Patent EP1572962.
JD094776 - Sequence 75800 from Patent EP1572962.
JD051014 - Sequence 32038 from Patent EP1572962.
JD054266 - Sequence 35290 from Patent EP1572962.
JD054266 - Sequence 35290 from Patent EP1572962.
JD054266 - Sequence 35290 from Patent EP1572962.
JD054266 - Sequence 35290 from Patent EP1572962.
JD150554 - Sequence 131578 from Patent EP1572962.
JD389525 - Sequence 370549 from Patent EP1572962.
KJ896802 - Synthetic construct Homo sapiens clone ccsbBroadEn_06196 FCER2 gene, encodes complete protein.
DQ892235 - Synthetic construct clone IMAGE:100004865; FLH184383.01X; RZPDo839F04144D Fc fragment of IgE, low affinity II, receptor for (CD23) (FCER2) gene, encodes complete protein.
EU176675 - Synthetic construct Homo sapiens clone IMAGE:100011475; FLH184382.01L; RZPDo839B02255D Fc fragment of IgE, low affinity II, receptor for (CD23) (FCER2) gene, encodes complete protein.
E02912 - cDNA encoding human IgE binding factor.
AB463630 - Synthetic construct DNA, clone: pF1KB6461, Homo sapiens FCER2 gene for Fc fragment of IgE, without stop codon, in Flexi system.
CU680780 - Synthetic construct Homo sapiens gateway clone IMAGE:100018907 5' read FCER2 mRNA.
AK310707 - Homo sapiens cDNA, FLJ17749.
JD177854 - Sequence 158878 from Patent EP1572962.
JD051477 - Sequence 32501 from Patent EP1572962.
JD445195 - Sequence 426219 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein P06734 (Reactome details) participates in the following event(s):

R-HSA-2197563 NOTCH2 intracellular domain regulates transcription
R-HSA-6785807 Interleukin-4 and 13 signaling
R-HSA-6783783 Interleukin-10 signaling
R-HSA-1980145 Signaling by NOTCH2
R-HSA-449147 Signaling by Interleukins
R-HSA-157118 Signaling by NOTCH
R-HSA-1280215 Cytokine Signaling in Immune system
R-HSA-162582 Signal Transduction
R-HSA-168256 Immune System

-  Other Names for This Gene
  Alternate Gene Symbols: CD23A, CLEC4J, ENST00000597921.1, ENST00000597921.2, ENST00000597921.3, ENST00000597921.4, ENST00000597921.5, FCE2, FCER2_HUMAN, IGEBF, NM_002002, P06734, uc327cqi.1, uc327cqi.2
UCSC ID: ENST00000597921.6_9
RefSeq Accession: NM_001220500.2
Protein: P06734 (aka FCER2_HUMAN or FCE2_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.