ID:FCGR1_HUMAN DESCRIPTION: RecName: Full=High affinity immunoglobulin gamma Fc receptor I; Short=IgG Fc receptor I; AltName: Full=Fc-gamma RI; Short=FcRI; AltName: Full=Fc-gamma RIA; Short=FcgammaRIa; AltName: CD_antigen=CD64; Flags: Precursor; FUNCTION: High affinity receptor for the Fc region of immunoglobulins gamma. Functions in both innate and adaptive immune responses. SUBUNIT: Interacts with FCERG1; forms a functional signaling complex. Interacts with FLNA; prevents FCGR1A degradation. Interacts with EPB41L2, LAT and PPL. Interacts with HCK and LYN. SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein. Note=Stabilized at the cell membrane through interaction with FCER1G. TISSUE SPECIFICITY: Monocyte/macrophage specific. PTM: Phosphorylated on serine residues (By similarity). SIMILARITY: Belongs to the immunoglobulin superfamily. FCGR1 family. SIMILARITY: Contains 3 Ig-like C2-type (immunoglobulin-like) domains. WEB RESOURCE: Name=FCGR1Abase; Note=FCGR1A mutation db; URL="http://bioinf.uta.fi/FCGR1Abase/";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P12314
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
X14355 - Human mRNA for high affinity Fc receptor (FcRI) 'b form'. AK291502 - Homo sapiens cDNA FLJ77773 complete cds, highly similar to Homo sapiens Fc fragment of IgG, high affinity Ia, receptor (CD64) (FCGR1A), mRNA. DQ786309 - Homo sapiens clone HLS_IMAGE_795343 mRNA sequence. LP895722 - Sequence 586 from Patent EP3253886. AK311303 - Homo sapiens cDNA, FLJ18345. X14356 - Human mRNA for high affinity Fc receptor (FcRI). AK291451 - Homo sapiens cDNA FLJ75382 complete cds, highly similar to Homo sapiens Fc fragment of IgG, high affinity Ia, receptor (CD64) (FCGR1A), mRNA. JD432124 - Sequence 413148 from Patent EP1572962. BC032634 - Homo sapiens Fc fragment of IgG, high affinity Ia, receptor (CD64), mRNA (cDNA clone MGC:45021 IMAGE:5248549), complete cds. CU689454 - Synthetic construct Homo sapiens gateway clone IMAGE:100019133 5' read FCGR1A mRNA. AB527585 - Synthetic construct DNA, clone: pF1KB6561, Homo sapiens FCGR1A gene for Fc fragment of IgG, high affinity Ia, receptor, without stop codon, in Flexi system. DQ893997 - Synthetic construct Homo sapiens clone IMAGE:100008457; FLH166386.01L; RZPDo839G0485D Fc fragment of IgG, high affinity Ia, receptor (CD64) (FCGR1A) gene, encodes complete protein. KJ896803 - Synthetic construct Homo sapiens clone ccsbBroadEn_06197 FCGR1A gene, encodes complete protein. BC152383 - Homo sapiens Fc fragment of IgG, high affinity Ia, receptor (CD64), mRNA (cDNA clone MGC:166938 IMAGE:100013442), complete cds. DQ890842 - Synthetic construct clone IMAGE:100003472; FLH166390.01X; RZPDo839G0486D Fc fragment of IgG, high affinity Ia, receptor (CD64) (FCGR1A) gene, encodes complete protein. L03418 - Human Fc-gamma receptor I A1 mRNA, complete cds. JD423299 - Sequence 404323 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein P12314 (Reactome details) participates in the following event(s):
R-HSA-2029455 Cross-linking of FCGRIA with IgG-coated Ag R-HSA-5685602 NCR3LG1 binds NCR3 R-HSA-6793275 CMVPP65 binds NCR3 R-HSA-5685600 viral HA binds NCRI R-HSA-1236939 Interaction of exogenous soluble antigen with its corresponding receptor R-HSA-1236940 Exogenous soluble antigen targeted to more stable early endosome R-HSA-2029452 Recruitment of SYK to phosphorylated ITAMs R-HSA-1236941 Internalization of receptor bound antigen into clathrin coted vesicles R-HSA-1236955 Movement of clathrin coated vesicles into early endosome R-HSA-2029449 Phosphorylation of SYK by Src kinases R-HSA-2029270 Recruitment of PLCgamma to membrane R-HSA-2029273 PI3K binds to p-6Y-SYK R-HSA-2029458 Recruitment of VAV1 to p-6Y-SYK R-HSA-2197697 Recruitment of CRKII:DOCK180:ELMO complex to FCGR R-HSA-2029272 Release of PLCG from FCGR R-HSA-2029453 Phosphorylation of VAV R-HSA-2029268 Phosphorylation and activation of PLCG R-HSA-2029467 Activation of RAC1 by CRKII:DOCK180:ELMO R-HSA-2029451 Activation of RAC1 by VAV R-HSA-2029271 PI3K phosphorylates PIP2 to PIP3 R-HSA-2029481 FCGR activation R-HSA-877300 Interferon gamma signaling R-HSA-2029480 Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-1236978 Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-913531 Interferon Signaling R-HSA-168249 Innate Immune System R-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation R-HSA-1280218 Adaptive Immune System R-HSA-1236975 Antigen processing-Cross presentation R-HSA-1280215 Cytokine Signaling in Immune system R-HSA-168256 Immune System R-HSA-2029485 Role of phospholipids in phagocytosis R-HSA-983169 Class I MHC mediated antigen processing & presentation
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
