ID:FCG2B_HUMAN DESCRIPTION: RecName: Full=Low affinity immunoglobulin gamma Fc region receptor II-b; Short=IgG Fc receptor II-b; AltName: Full=CDw32; AltName: Full=Fc-gamma RII-b; Short=Fc-gamma-RIIb; Short=FcRII-b; AltName: CD_antigen=CD32; Flags: Precursor; FUNCTION: Receptor for the Fc region of complexed or aggregated immunoglobulins gamma. Low affinity receptor. Involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by B- cells. Binding to this receptor results in down-modulation of previous state of cell activation triggered via antigen receptors on B-cells (BCR), T-cells (TCR) or via another Fc receptor. Isoform IIB1 fails to mediate endocytosis or phagocytosis. Isoform IIB2 does not trigger phagocytosis. SUBUNIT: Isoform IIB1 interacts with measles virus N protein. N protein is released in the blood following lysis of measles infected cells. This interaction presumably block inflammatory immune response. Interacts with INPP5D/SHIP1. Interacts with FGR. Interacts with LYN. INTERACTION: P01857:IGHG1; NbExp=31; IntAct=EBI-724784, EBI-356114; P16333:NCK1; NbExp=2; IntAct=EBI-724784, EBI-389883; P19174:PLCG1; NbExp=2; IntAct=EBI-724784, EBI-79387; SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein. TISSUE SPECIFICITY: Is the most broadly distributed Fc-gamma- receptor. Expressed in monocyte, neutrophils, macrophages, basophils, eosinophils, Langerhans cells, B-cells, platelets cells and placenta (endothelial cells). Not detected in natural killer cells. DOMAIN: Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2- containing phosphatases. PTM: Phosphorylated by SRC-type Tyr-kinases such as LYN, BLK, FYN and SYK. POLYMORPHISM: Note=FCGR2B polymorphisms can influence susceptibility or resistance to malaria [MIM:611162]. DISEASE: Note=A chromosomal aberration involving FCGR2B is found in a follicular lymphoma. Translocation t(1;22)(q22;q11). The translocation leads to the hyperexpression of the receptor. This may play a role in the tumor progression. DISEASE: Defects in FCGR2B are a cause of susceptibility to systemic lupus erythematosus (SLE) [MIM:152700]. A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow. SIMILARITY: Contains 2 Ig-like C2-type (immunoglobulin-like) domains. CAUTION: Has sometimes been attributed to correspond to FcR-IIC. SEQUENCE CAUTION: Sequence=CAA35645.1; Type=Erroneous initiation; WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/FCGR2BID397.html";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P31994
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0001811 negative regulation of type I hypersensitivity GO:0001814 negative regulation of antibody-dependent cellular cytotoxicity GO:0002266 follicular dendritic cell activation GO:0002313 mature B cell differentiation involved in immune response GO:0002316 follicular B cell differentiation GO:0002436 immune complex clearance by monocytes and macrophages GO:0002605 negative regulation of dendritic cell antigen processing and presentation GO:0002622 regulation of B cell antigen processing and presentation GO:0002638 negative regulation of immunoglobulin production GO:0002819 regulation of adaptive immune response GO:0002865 negative regulation of acute inflammatory response to antigenic stimulus GO:0002922 positive regulation of humoral immune response GO:0002924 negative regulation of humoral immune response mediated by circulating immunoglobulin GO:0006898 receptor-mediated endocytosis GO:0006911 phagocytosis, engulfment GO:0006952 defense response GO:0006954 inflammatory response GO:0006955 immune response GO:0007165 signal transduction GO:0009617 response to bacterium GO:0010469 regulation of receptor activity GO:0016032 viral process GO:0016064 immunoglobulin mediated immune response GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II GO:0021549 cerebellum development GO:0030889 negative regulation of B cell proliferation GO:0032693 negative regulation of interleukin-10 production GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis GO:0043031 negative regulation of macrophage activation GO:0043318 negative regulation of cytotoxic T cell degranulation GO:0045088 regulation of innate immune response GO:0046330 positive regulation of JNK cascade GO:0050710 negative regulation of cytokine secretion GO:0050765 negative regulation of phagocytosis GO:0050766 positive regulation of phagocytosis GO:0050776 regulation of immune response GO:0050777 negative regulation of immune response GO:0050869 negative regulation of B cell activation GO:0071219 cellular response to molecule of bacterial origin GO:0090264 regulation of immune complex clearance by monocytes and macrophages GO:1901216 positive regulation of neuron death GO:1902564 negative regulation of neutrophil activation GO:1902950 regulation of dendritic spine maintenance GO:1904646 cellular response to beta-amyloid GO:2001199 negative regulation of dendritic cell differentiation GO:0045576 mast cell activation
M31933 - Human IgG low affinity Fc fragment receptor (FcRIIb3) mRNA, complete cds. AF543826 - Homo sapiens IgG receptor IIB (FCGR2B) mRNA, complete cds. X17653 - H.sapiens hFcRII-C isoform mRNA for IgG Fc receptor hFcRII. JD405038 - Sequence 386062 from Patent EP1572962. AK308150 - Homo sapiens cDNA, FLJ98098. AB209585 - Homo sapiens mRNA for Fc fragment of IgG, low affinity IIb, receptor for (CD32) isoform 1 variant protein. BC062629 - Homo sapiens cDNA clone IMAGE:5227673, **** WARNING: chimeric clone ****. X52473 - Human mRNA for beta-Fc-gamma receptor II. X62573 - H.sapiens RNA for Fc receptor, TC9. BC146678 - Homo sapiens Fc fragment of IgG, low affinity IIb, receptor (CD32), mRNA (cDNA clone MGC:165089 IMAGE:40148906), complete cds. M28696 - Human low-affinity IgG Fc receptor (beta-Fc-gamma-RII) mRNA, complete cds. M31934 - Human IgG low affinity Fc fragment receptor (FcRIIb2) mRNA, complete cds. BC031992 - Homo sapiens Fc fragment of IgG, low affinity IIb, receptor (CD32), mRNA (cDNA clone MGC:21364 IMAGE:4752609), complete cds. BC141826 - Homo sapiens Fc fragment of IgG, low affinity IIb, receptor (CD32), mRNA (cDNA clone MGC:164959 IMAGE:40148276), complete cds. JD478135 - Sequence 459159 from Patent EP1572962. JD149684 - Sequence 130708 from Patent EP1572962. AB590317 - Synthetic construct DNA, clone: pFN21AE1428, Homo sapiens FCGR2B gene for Fc fragment of IgG, low affinity IIb, receptor, without stop codon, in Flexi system. CR407635 - Homo sapiens full open reading frame cDNA clone RZPDo834F022D for gene FCGR2B, Fc fragment of IgG, low affinity IIb, receptor for (CD32) complete cds, without stopcodon. U87560 - Human Fc-gamma-RIIb1 (Fc-gamma-RIIB) mRNA, partial cds. U87561 - Human Fc-gamma-RIIb1 (Fc-gamma-RIIB) mRNA, partial cds. U87562 - Human Fc-gamma-RIIb1 (Fc-gamma-RIIB) mRNA, partial cds. U87563 - Human Fc-gamma-RIIb1 (Fc-gamma-RIIB) mRNA, partial cds. U87564 - Human Fc-gamma-RIIb2 (Fc-gamma-RIIB) mRNA, partial cds. U87565 - Human Fc-gamma-RIIb2 (Fc-gamma-RIIB) mRNA, partial cds. U87566 - Human Fc-gamma-RIIb2 (Fc-gamma-RIIB) mRNA, partial cds. U87567 - Human Fc-gamma-RIIb2 (Fc-gamma-RIIB) mRNA, partial cds. U87568 - Human Fc-gamma-RIIb2 (Fc-gamma-RIIB) mRNA, partial cds. U87569 - Human Fc-gamma-RIIb2 (Fc-gamma-RIIB) mRNA, partial cds. U87570 - Human Fc-gamma-RIIb1 (Fc-gamma-RIIB) mRNA, partial cds. U87571 - Human Fc-gamma-RIIb2 (Fc-gamma-RIIB) mRNA, partial cds. U87572 - Human Fc-gamma-RIIb1 (Fc-gamma-RIIB) mRNA, partial cds. U87573 - Human Fc-gamma-RIIb1 (Fc-gamma-RIIB) mRNA, partial cds. U87574 - Human Fc-gamma-RIIb2 (Fc-gamma-RIIB) mRNA, partial cds. U87575 - Human Fc-gamma-RIIb2 (Fc-gamma-RIIB) mRNA, partial cds. U87576 - Human Fc-gamma-RIIb1 (Fc-gamma-RIIB) mRNA, partial cds. U87577 - Human Fc-gamma-RIIb1 (Fc-gamma-RIIB) mRNA, partial cds. CU689254 - Synthetic construct Homo sapiens gateway clone IMAGE:100018829 5' read FCGR2B mRNA. DQ894525 - Synthetic construct Homo sapiens clone IMAGE:100008985; FLH171251.01L; RZPDo839G0499D Fc fragment of IgG, low affinity IIc, receptor for (CD32) (FCGR2C) gene, encodes complete protein. KJ891152 - Synthetic construct Homo sapiens clone ccsbBroadEn_00546 FCGR2B gene, encodes complete protein. KR710627 - Synthetic construct Homo sapiens clone CCSBHm_00014872 FCGR2B (FCGR2B) mRNA, encodes complete protein. BC148273 - Homo sapiens Fc fragment of IgG, low affinity IIb, receptor (CD32), mRNA (cDNA clone MGC:166965 IMAGE:8860219), complete cds. DQ891344 - Synthetic construct clone IMAGE:100003974; FLH171255.01X; RZPDo839G04100D Fc fragment of IgG, low affinity IIc, receptor for (CD32) (FCGR2C) gene, encodes complete protein. M31935 - Human IgG low affinity Fc fragment receptor (FcRIIb1) mRNA, 3' end. AB051387 - Homo sapiens FCGR2B mRNA for Fc gamma receptor IIB, partial cds. AB050934 - Homo sapiens FCGR2B mRNA for Fc gamma receptor IIB, partial cds. JD208043 - Sequence 189067 from Patent EP1572962. JD358779 - Sequence 339803 from Patent EP1572962. JD062123 - Sequence 43147 from Patent EP1572962. JD490267 - Sequence 471291 from Patent EP1572962. JD547452 - Sequence 528476 from Patent EP1572962. JD511952 - Sequence 492976 from Patent EP1572962. JD306850 - Sequence 287874 from Patent EP1572962. JD296573 - Sequence 277597 from Patent EP1572962.
Biochemical and Signaling Pathways
BioCarta from NCI Cancer Genome Anatomy Project h_blymphocytePathway - B Lymphocyte Cell Surface Molecules
Reactome (by CSHL, EBI, and GO)
Protein P31994 (Reactome details) participates in the following event(s):
R-HSA-199161 Fc gamma receptors interact with antigen-bound IgG R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-1280218 Adaptive Immune System R-HSA-168256 Immune System
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
