ID:FCHO2_HUMAN DESCRIPTION: RecName: Full=FCH domain only protein 2; FUNCTION: Functions in an early step of clathrin-mediated endocytosis. Has both a membrane binding/bending activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. Has a lipid-binding activity with a preference for membranes enriched in phosphatidylserine and phosphoinositides (Pi(4,5) biphosphate) like the plasma membrane. Its membrane-bending activity might be important for the subsequent action of clathrin and adaptors in the formation of clathrin-coated vesicles. Involved in adaptor protein complex AP- 2-dependent endocytosis of the transferin receptor, it also functions in the AP-2-independent endocytosis of the LDL receptor. SUBUNIT: Homodimer; disulfide-linked. May form homotetramer. Interacts with AP2A1. Interacts with EPS15, EPS15R, ITSN1 and ITSN2; recruit those scaffolding proteins which in turn may interact with the adaptor protein complex AP-2 at the plasma membrane. Interacts with DAB2 (via DPF motifs); mediates LDL receptor/LDLR endocytosis. INTERACTION: P98078:Dab2 (xeno); NbExp=4; IntAct=EBI-2609756, EBI-1391846; P42566:EPS15; NbExp=3; IntAct=EBI-2609756, EBI-396684; SUBCELLULAR LOCATION: Membrane, clathrin-coated pit; Peripheral membrane protein; Cytoplasmic side (By similarity). Note=Associated with forming but not mature clathrin-coated vesicles. The recruitment to coated-pits precede the one of clathrin and the adaptor protein complex AP-2 (By similarity). PTM: Ubiquitinated. Mainly undergoes monoubiquitination but also polyubiquitination (By similarity). MISCELLANEOUS: Deforms liposomes into a range of tubule diameters from 20 to 130 nm in vitro. SIMILARITY: Belongs to the FCHO family. SIMILARITY: Contains 1 FCH domain. SIMILARITY: Contains 1 MUHD (Muniscin C-terminal mu homology domain) domain. SEQUENCE CAUTION: Sequence=AAH14311.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q0JRZ9
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
