ID:O3FA1_HUMAN DESCRIPTION: RecName: Full=Omega-3 fatty acid receptor 1; AltName: Full=G-protein coupled receptor 120; AltName: Full=G-protein coupled receptor 129; AltName: Full=G-protein coupled receptor GT01; AltName: Full=G-protein coupled receptor PGR4; FUNCTION: Receptor for medium and long-chain free fatty acid (FAA). Signals via a G(q)/G(11)-coupled pathway. Acts as a receptor for omega-3 fatty acids and mediates robust anti- inflammatory effects particularly in macrophages and fat cells. The anti-inflammatory effects involve inhibition of TAK1 through a beta-arrestin 2 (ARRB2)/TAB1 dependent effect but independent of G(q)/G(11)-coupled pathway. Mediates potent insulin sensitizing and antidiabetic effects by repressing macrophage-induced tissue inflammation. May mediate the taste of fatty acids (By similarity). SUBUNIT: Interacts with ARRB2 following docosahexaenoic acid (DHA) stimulation (By similarity). SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein (By similarity). Note=Colocalized with ARRB2 following DHA treatment (By similarity). TISSUE SPECIFICITY: Abundant expression in the intestinal tract. PTM: Phosphorylated. FFA stimulation facilitates phosphorylation. POLYMORPHISM: Genetic variations in O3FAR1 define the body mass index quantitative trait locus 10 (BMIQ10) [MIM:607514]. Variance in body mass index is a susceptibility factor for obesity. MISCELLANEOUS: It has been shown that FFA alpha-linolenic acid stimulate secretion of glucagon-like peptide 1 (GLP-1) from the gastro-intestinal tract (PubMed:15619630). However, this ligand is an agonist of both GPR120 and FFA1 and the latter has been shown to mediate GLP-1 release too (PubMed:18519800). So the precise role of GPR120 in mediating needs to be confirmed. SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
SCOP Domains: 81321 - Family A G protein-coupled receptor-like
ModBase Predicted Comparative 3D Structure on Q5NUL3
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
