Human Gene FGB (ENST00000302068.9_4) from GENCODE V47lift37
  Description: fibrinogen beta chain, transcript variant 1 (from RefSeq NM_005141.5)
Gencode Transcript: ENST00000302068.9_4
Gencode Gene: ENSG00000171564.12_6
Transcript (Including UTRs)
   Position: hg19 chr4:155,484,163-155,493,959 Size: 9,797 Total Exon Count: 8 Strand: +
Coding Region
   Position: hg19 chr4:155,484,171-155,491,802 Size: 7,632 Coding Exon Count: 8 

Page IndexSequence and LinksPrimersMalaCardsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureOther SpeciesmRNA DescriptionsPathways
Other NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr4:155,484,163-155,493,959)mRNA (may differ from genome)Protein (491 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedUniProtKB
WikipediaBioGrid CRISPR DB

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: FGB
Diseases sorted by gene-association score: afibrinogenemia, congenital* (912), dysfibrinogenemia, congenital* (680), afibrinogenemia* (461), fgb-related congenital afibrinogenemia* (100), dysfibrinogenemia (28), lateral medullary syndrome (11), brain stem infarction (10), hepatitis e (8), chronic thromboembolic pulmonary hypertension (7), inherited blood coagulation disease (5), myocardial infarction (2)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 4876.66 RPKM in Liver
Total median expression: 4891.14 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
3' UTR -487.612157-0.226 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGDEnsembl   
      
      

-  Descriptions from all associated GenBank mRNAs
  AK312972 - Homo sapiens cDNA, FLJ93433, highly similar to Homo sapiens fibrinogen, B beta polypeptide (FGB), mRNA.
EU668333 - Homo sapiens epididymis secretory sperm binding protein Li 78p (HEL-S-78p) mRNA, complete cds.
AK311683 - Homo sapiens cDNA, FLJ18725.
BC106760 - Homo sapiens fibrinogen beta chain, mRNA (cDNA clone MGC:120405 IMAGE:40024790), complete cds.
AK303788 - Homo sapiens cDNA FLJ53952 complete cds, highly similar to Fibrinogen beta chain precursor.
BC036007 - Homo sapiens fibrinogen beta chain, mRNA (cDNA clone IMAGE:4767275).
BC007030 - Homo sapiens fibrinogen beta chain, mRNA (cDNA clone IMAGE:4071515), partial cds.
BC020762 - Homo sapiens fibrinogen beta chain, mRNA (cDNA clone IMAGE:4767234), **** WARNING: chimeric clone ****.
BC107766 - Homo sapiens fibrinogen beta chain, mRNA (cDNA clone MGC:104327 IMAGE:4734415), complete cds.
BC060040 - Homo sapiens cDNA clone IMAGE:4716456, partial cds.
AB527849 - Synthetic construct DNA, clone: pF1KB5866, Homo sapiens FGB gene for fibrinogen beta chain, without stop codon, in Flexi system.
KJ891160 - Synthetic construct Homo sapiens clone ccsbBroadEn_00554 FGB gene, encodes complete protein.
KR711518 - Synthetic construct Homo sapiens clone CCSBHm_00025138 FGB (FGB) mRNA, encodes complete protein.
KR711519 - Synthetic construct Homo sapiens clone CCSBHm_00025145 FGB (FGB) mRNA, encodes complete protein.
KR711520 - Synthetic construct Homo sapiens clone CCSBHm_00025155 FGB (FGB) mRNA, encodes complete protein.
KR711521 - Synthetic construct Homo sapiens clone CCSBHm_00025157 FGB (FGB) mRNA, encodes complete protein.
BC070245 - Homo sapiens fibrinogen beta chain, mRNA (cDNA clone IMAGE:4734204).
AK309592 - Homo sapiens cDNA, FLJ99633.
J00129 - Human fibrinogen beta-chain mRNA, partial cds.
JD019995 - Sequence 1019 from Patent EP1572962.
JD022189 - Sequence 3213 from Patent EP1572962.
JD035992 - Sequence 17016 from Patent EP1572962.
J00133 - human fibrinogen b-beta-chain mRNA, 3' end.
JD019780 - Sequence 804 from Patent EP1572962.
JD023719 - Sequence 4743 from Patent EP1572962.
JD023995 - Sequence 5019 from Patent EP1572962.
JD035235 - Sequence 16259 from Patent EP1572962.
JD160620 - Sequence 141644 from Patent EP1572962.
JD308380 - Sequence 289404 from Patent EP1572962.
JD036477 - Sequence 17501 from Patent EP1572962.
JD522283 - Sequence 503307 from Patent EP1572962.
JD329115 - Sequence 310139 from Patent EP1572962.
JD319326 - Sequence 300350 from Patent EP1572962.
JD319327 - Sequence 300351 from Patent EP1572962.
JD036734 - Sequence 17758 from Patent EP1572962.
JD105358 - Sequence 86382 from Patent EP1572962.
JD070834 - Sequence 51858 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  BioCarta from NCI Cancer Genome Anatomy Project
h_extrinsicPathway - Extrinsic Prothrombin Activation Pathway
h_intrinsicPathway - Intrinsic Prothrombin Activation Pathway
h_amiPathway - Acute Myocardial Infarction
h_fibrinolysisPathway - Fibrinolysis Pathway

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000302068.1, ENST00000302068.2, ENST00000302068.3, ENST00000302068.4, ENST00000302068.5, ENST00000302068.6, ENST00000302068.7, ENST00000302068.8, FGB , HEL-S-78p , NM_005141, uc317myi.1, uc317myi.2, V9HVY1, V9HVY1_HUMAN
UCSC ID: ENST00000302068.9_4
RefSeq Accession: NM_005141.5

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.