ID:FGD2_HUMAN DESCRIPTION: RecName: Full=FYVE, RhoGEF and PH domain-containing protein 2; AltName: Full=Zinc finger FYVE domain-containing protein 4; FUNCTION: Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Activates JNK1 via CDC42 but not RAC1. Binds to phosphatidylinositol 4,5- bisphosphate, phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 5-monophosphate, phosphatidylinositol 4- monophosphate and phosphatidylinositol 3-monophosphate (By similarity). SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton (Probable). Cytoplasm (By similarity). Nucleus (By similarity). Early endosome (By similarity). Early endosome membrane (By similarity). Cell projection, ruffle membrane (By similarity). Note=Recruitment to the endosome and ruffle membrane requires the presence of phosphoinositides (By similarity). DOMAIN: The FYVE-type zinc-finger is necessary for early endosome localization. Recruitment to endosomal membranes via this domain requires the presence of phosphatidylinositol 3-phosphate or other phosphatidylinositides (By similarity). DOMAIN: The PH domain is necessary for localization to the ruffle membrane. Recruitment to ruffle membrane occurs through binding of phosphoinositides by the PH domain. This domain also contributes to the lipid-binding properties of the protein (By similarity). DOMAIN: The DH domain is necessary for its ability to activate JNK1 via CDC42 (By similarity). SIMILARITY: Contains 1 DH (DBL-homology) domain. SIMILARITY: Contains 1 FYVE-type zinc finger. SIMILARITY: Contains 2 PH domains. SEQUENCE CAUTION: Sequence=BAB15746.1; Type=Erroneous initiation; Sequence=BAC85129.1; Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=BAC85129.1; Type=Frameshift; Positions=460; Sequence=CAI20471.1; Type=Erroneous gene model prediction;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q7Z6J4
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0005085 guanyl-nucleotide exchange factor activity GO:0005089 Rho guanyl-nucleotide exchange factor activity GO:0005515 protein binding GO:0031267 small GTPase binding GO:0046872 metal ion binding GO:1901981 phosphatidylinositol phosphate binding
Biological Process: GO:0007010 cytoskeleton organization GO:0007186 G-protein coupled receptor signaling pathway GO:0008360 regulation of cell shape GO:0030036 actin cytoskeleton organization GO:0035023 regulation of Rho protein signal transduction GO:0043065 positive regulation of apoptotic process GO:0043087 regulation of GTPase activity GO:0043507 positive regulation of JUN kinase activity GO:0046847 filopodium assembly GO:0051056 regulation of small GTPase mediated signal transduction
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
