ID:FGF13_HUMAN DESCRIPTION: RecName: Full=Fibroblast growth factor 13; Short=FGF-13; AltName: Full=Fibroblast growth factor homologous factor 2; Short=FHF-2; FUNCTION: Microtubule-binding protein which directly binds tubulin and is involved in both polymerization and stabilization of microtubules. Through its action on microtubules, may participate to the refinement of axons by negatively regulating axonal and leading processes branching. Plays a crucial role in neuron polarization and migration in the cerebral cortex and the hippocampus. FUNCTION: May regulate voltage-gated sodium channels transport and function. FUNCTION: May also play a role in MAPK signaling. SUBUNIT: Interacts with SCN8A; may regulate SCN8A activity. Interacts with SCN1A; may regulate SCN1A activity. Interacts with SCN5A; the interaction is direct and may regulate SNC5A density at membranes and function. May also interact with SCN2A and SCN11A. Interacts with MAPK8IP2; may regulate the MAPK8IP2 scaffolding activity. SUBCELLULAR LOCATION: Cell projection, filopodium (By similarity). Cell projection, growth cone (By similarity). Cell projection, dendrite (By similarity). Nucleus. Cytoplasm. Note=Not secreted (By similarity). SUBCELLULAR LOCATION: Isoform 1: Nucleus, nucleolus. SUBCELLULAR LOCATION: Isoform 2: Cytoplasm. Nucleus. TISSUE SPECIFICITY: Ubiquitously expressed. Predominantly expressed in the nervous system. PTM: May be phosphorylated (By similarity). SIMILARITY: Belongs to the heparin-binding growth factors family. WEB RESOURCE: Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/fgf13/";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q92913
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0000165 MAPK cascade GO:0001764 neuron migration GO:0006814 sodium ion transport GO:0007026 negative regulation of microtubule depolymerization GO:0007165 signal transduction GO:0007267 cell-cell signaling GO:0007399 nervous system development GO:0007612 learning GO:0007613 memory GO:0010469 regulation of receptor activity GO:0021766 hippocampus development GO:0021795 cerebral cortex cell migration GO:0032147 activation of protein kinase activity GO:0045200 establishment of neuroblast polarity GO:0046785 microtubule polymerization GO:0048671 negative regulation of collateral sprouting GO:0072659 protein localization to plasma membrane GO:0098909 regulation of cardiac muscle cell action potential involved in regulation of contraction GO:1990834 response to odorant
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
