ID:FHIT_HUMAN DESCRIPTION: RecName: Full=Bis(5'-adenosyl)-triphosphatase; EC=3.6.1.29; AltName: Full=AP3A hydrolase; Short=AP3Aase; AltName: Full=Diadenosine 5',5'''-P1,P3-triphosphate hydrolase; AltName: Full=Dinucleosidetriphosphatase; AltName: Full=Fragile histidine triad protein; FUNCTION: Cleaves A-5'-PPP-5'A to yield AMP and ADP. Possible tumor suppressor for specific tissues. CATALYTIC ACTIVITY: P(1)-P(3)-bis(5'-adenosyl) triphosphate + H(2)O = ADP + AMP. COFACTOR: Divalent cations. Magnesium, but manganese and to a lesser extent calcium or cobalt can be substituted; but not zinc, cadmium or nickel. SUBUNIT: Homodimer. INTERACTION: P22570:FDXR; NbExp=4; IntAct=EBI-741760, EBI-1751533; P10809:HSPD1; NbExp=5; IntAct=EBI-741760, EBI-352528; P61604:HSPE1; NbExp=4; IntAct=EBI-741760, EBI-711483; SUBCELLULAR LOCATION: Cytoplasm. TISSUE SPECIFICITY: Low levels expressed in all tissues tested. Phospho-FHIT observed in liver and kidney, but not in brain and lung. Phospho-FHIT undetected in all tested human tumor cell lines. MASS SPECTROMETRY: Mass=16733; Method=MALDI; Range=2-147; Source=PubMed:15007172; DISEASE: Note=A chromosomal aberration involving FHIT has been found in a lymphoblastoid cell line established from a family with renal cell carcinoma and thyroid carcinoma. Translocation t(3;8)(p14.2;q24.1) with RNF139. Although the 3p14.2 breakpoint has been shown to interrupt FHIT in its 5-prime non-coding region, it is unlikely that FHIT is causally related to renal or other malignancies. DISEASE: Note=Associated with digestive tract cancers. Numerous tumor types are found to have aberrant forms of FHIT protein due to deletions in a coding region of chromosome 3p14.2 including the fragile site locus FRA3B. SIMILARITY: Contains 1 HIT domain. WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/FHITID192ch3p14.html";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P49789
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006163 purine nucleotide metabolic process GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006915 apoptotic process GO:0009117 nucleotide metabolic process GO:0032435 negative regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
