ID:VEGFD_HUMAN DESCRIPTION: RecName: Full=Vascular endothelial growth factor D; Short=VEGF-D; AltName: Full=c-Fos-induced growth factor; Short=FIGF; Flags: Precursor; FUNCTION: Growth factor active in angiogenesis, lymphangiogenesis and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of blood vessels. May function in the formation of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in adults. Binds and activates VEGFR-2 (KDR/FLK1) and VEGFR-3 (FLT4) receptors. SUBUNIT: Homodimer; non-covalent and antiparallel. SUBCELLULAR LOCATION: Secreted. TISSUE SPECIFICITY: Highly expressed in lung, heart, small intestine and fetal lung, and at lower levels in skeletal muscle, colon, and pancreas. PTM: Undergoes a complex proteolytic maturation which generates a variety of processed secreted forms with increased activity toward VEGFR-3 and VEGFR-2. VEGF-D first form an antiparallel homodimer linked by disulfide bonds before secretion. The fully processed VEGF-D is composed mostly of two VEGF homology domains (VHDs) bound by non-covalent interactions. SIMILARITY: Belongs to the PDGF/VEGF growth factor family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O43915
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Protein O43915 (Reactome details) participates in the following event(s):
R-HSA-195378 Homodimerization of VEGF proteins R-HSA-481007 Exocytosis of platelet alpha granule contents R-HSA-194308 VEGF-C,D bind to VEGFR3 leading to receptor dimerization R-HSA-194310 VEGF-A,C,D bind to VEGFR2 leading to receptor dimerization R-HSA-194313 VEGF ligand-receptor interactions R-HSA-114608 Platelet degranulation R-HSA-195399 VEGF binds to VEGFR leading to receptor dimerization R-HSA-194138 Signaling by VEGF R-HSA-76005 Response to elevated platelet cytosolic Ca2+ R-HSA-9006934 Signaling by Receptor Tyrosine Kinases R-HSA-76002 Platelet activation, signaling and aggregation R-HSA-162582 Signal Transduction R-HSA-109582 Hemostasis
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
