ID:FKB1A_HUMAN DESCRIPTION: RecName: Full=Peptidyl-prolyl cis-trans isomerase FKBP1A; Short=PPIase FKBP1A; EC=5.2.1.8; AltName: Full=12 kDa FK506-binding protein; Short=12 kDa FKBP; Short=FKBP-12; AltName: Full=Calstabin-1; AltName: Full=FK506-binding protein 1A; Short=FKBP-1A; AltName: Full=Immunophilin FKBP12; AltName: Full=Rotamase; FUNCTION: Keeps in an inactive conformation TGFBR1, the TGF-beta type I serine/threonine kinase receptor, preventing TGF-beta receptor activation in absence of ligand. Recruites SMAD7 to ACVR1B which prevents the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. May modulate the RYR1 calcium channel activity. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. CATALYTIC ACTIVITY: Peptidylproline (omega=180) = peptidylproline (omega=0). ENZYME REGULATION: Inhibited by both FK506 and rapamycin. SUBUNIT: Interacts directly with RYR1, RYR2 and RYR3. Identified in a complex composed of RYR1, PDE4D, PKA, FKBP1A and protein phosphatase 1 (PP1) (By similarity). Interacts with TGFBR1; prevents TGFBR1 phosphorylation by TGFBR2 and stabilizes it in the inactive conformation. Interacts with ACVR1B and SMAD7. SUBCELLULAR LOCATION: Cytoplasm. SIMILARITY: Belongs to the FKBP-type PPIase family. FKBP1 subfamily. SIMILARITY: Contains 1 PPIase FKBP-type domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P62942
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0000413 protein peptidyl-prolyl isomerization GO:0003007 heart morphogenesis GO:0006457 protein folding GO:0006458 'de novo' protein folding GO:0007183 SMAD protein complex assembly GO:0022417 protein maturation by protein folding GO:0031398 positive regulation of protein ubiquitination GO:0032092 positive regulation of protein binding GO:0032515 negative regulation of phosphoprotein phosphatase activity GO:0032880 regulation of protein localization GO:0032925 regulation of activin receptor signaling pathway GO:0042026 protein refolding GO:0042110 T cell activation GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0050776 regulation of immune response GO:0055010 ventricular cardiac muscle tissue morphogenesis GO:0060314 regulation of ryanodine-sensitive calcium-release channel activity GO:0060347 heart trabecula formation GO:0061077 chaperone-mediated protein folding GO:0070588 calcium ion transmembrane transport GO:0097435 supramolecular fiber organization GO:1902991 regulation of amyloid precursor protein catabolic process GO:1990000 amyloid fibril formation GO:0051280 negative regulation of release of sequestered calcium ion into cytosol GO:0060315 negative regulation of ryanodine-sensitive calcium-release channel activity
AK309026 - Homo sapiens cDNA, FLJ99067. BC001925 - Homo sapiens FK506 binding protein 1A, 12kDa, mRNA (cDNA clone MGC:3950 IMAGE:2823635), complete cds. JA482230 - Sequence 213 from Patent WO2011072091. JE980522 - Sequence 213 from Patent EP2862929. M34539 - Human FK506-binding protein (FKBP) mRNA, complete cds. JD163620 - Sequence 144644 from Patent EP1572962. JD201732 - Sequence 182756 from Patent EP1572962. JD449584 - Sequence 430608 from Patent EP1572962. JD449583 - Sequence 430607 from Patent EP1572962. JD302923 - Sequence 283947 from Patent EP1572962. JD288785 - Sequence 269809 from Patent EP1572962. JD247547 - Sequence 228571 from Patent EP1572962. JD123316 - Sequence 104340 from Patent EP1572962. JD320698 - Sequence 301722 from Patent EP1572962. JD403984 - Sequence 385008 from Patent EP1572962. JD129971 - Sequence 110995 from Patent EP1572962. JD314663 - Sequence 295687 from Patent EP1572962. JD284797 - Sequence 265821 from Patent EP1572962. JD391466 - Sequence 372490 from Patent EP1572962. JD528231 - Sequence 509255 from Patent EP1572962. BC119732 - Homo sapiens FK506 binding protein 1A, 12kDa, mRNA (cDNA clone MGC:149764 IMAGE:40118164), complete cds. BC119733 - Homo sapiens FK506 binding protein 1A, 12kDa, mRNA (cDNA clone IMAGE:40118165), complete cds. JD392476 - Sequence 373500 from Patent EP1572962. JD376964 - Sequence 357988 from Patent EP1572962. JD546407 - Sequence 527431 from Patent EP1572962. JD270098 - Sequence 251122 from Patent EP1572962. JD270099 - Sequence 251123 from Patent EP1572962. JD338063 - Sequence 319087 from Patent EP1572962. JA482229 - Sequence 212 from Patent WO2011072091. JE980521 - Sequence 212 from Patent EP2862929. X52220 - Human FKBP mRNA for FK-506 binding protein. BC005147 - Homo sapiens FK506 binding protein 1A, 12kDa, mRNA (cDNA clone MGC:2167 IMAGE:3504715), complete cds. AB241124 - Homo sapiens FKBP12-Exip3 mRNA for FK506 binding protein12, complete cds. AB241123 - Homo sapiens FKBP12-Exip2 mRNA for FK506 binding protein12, complete cds. AB241125 - Homo sapiens FKBP12-Exin mRNA for FK506 binding protein12, complete cds. CR542168 - Homo sapiens full open reading frame cDNA clone RZPDo834C0724D for gene FKBP1A, FK506 binding protein 1A, 12kDa; complete cds, incl. stopcodon. KJ896819 - Synthetic construct Homo sapiens clone ccsbBroadEn_06213 FKBP1A gene, encodes complete protein. BT007066 - Homo sapiens FK506 binding protein 1A, 12kDa mRNA, complete cds. DQ891819 - Synthetic construct clone IMAGE:100004449; FLH180261.01X; RZPDo839A04134D FK506 binding protein 1A, 12kDa (FKBP1A) gene, encodes complete protein. KJ904464 - Synthetic construct Homo sapiens clone ccsbBroadEn_13858 FKBP1A gene, encodes complete protein. CR407613 - Homo sapiens full open reading frame cDNA clone RZPDo834F016D for gene FKBP1A, FK506 binding protein 1A, 12kDa complete cds, without stopcodon. E03395 - DNA encoding FK506 binding protein. AB463639 - Synthetic construct DNA, clone: pF1KB3544, Homo sapiens FKBP1A gene for FK506 binding protein 1A, without stop codon, in Flexi system. AF205192 - Homo sapiens FKBP-12 mRNA, partial cds. D28444 - Homo sapiens mRNA for FK506-binding protein, 5'UTR region. MP015226 - Sequence 429 from Patent WO2019016252. MA874661 - JP 2018536436-A/6497: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA874660 - JP 2018536436-A/6496: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA874659 - JP 2018536436-A/6495: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA874658 - JP 2018536436-A/6494: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA874657 - JP 2018536436-A/6493: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA874656 - JP 2018536436-A/6492: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA874655 - JP 2018536436-A/6491: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA874654 - JP 2018536436-A/6490: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA874653 - JP 2018536436-A/6489: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA874652 - JP 2018536436-A/6488: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA874651 - JP 2018536436-A/6487: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA874650 - JP 2018536436-A/6486: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA874649 - JP 2018536436-A/6485: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA874648 - JP 2018536436-A/6484: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA874647 - JP 2018536436-A/6483: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA874646 - JP 2018536436-A/6482: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA874645 - JP 2018536436-A/6481: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA874644 - JP 2018536436-A/6480: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA874643 - JP 2018536436-A/6479: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA874642 - JP 2018536436-A/6478: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA874641 - JP 2018536436-A/6477: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA874640 - JP 2018536436-A/6476: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA874639 - JP 2018536436-A/6475: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA874638 - JP 2018536436-A/6474: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA874637 - JP 2018536436-A/6473: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA874636 - JP 2018536436-A/6472: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA874635 - JP 2018536436-A/6471: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA874634 - JP 2018536436-A/6470: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA874632 - JP 2018536436-A/6468: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA874631 - JP 2018536436-A/6467: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA874630 - JP 2018536436-A/6466: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA874629 - JP 2018536436-A/6465: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA874628 - JP 2018536436-A/6464: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA874627 - JP 2018536436-A/6463: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA874626 - JP 2018536436-A/6462: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA874625 - JP 2018536436-A/6461: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA874624 - JP 2018536436-A/6460: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA874623 - JP 2018536436-A/6459: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA874622 - JP 2018536436-A/6458: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA874621 - JP 2018536436-A/6457: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA874620 - JP 2018536436-A/6456: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA874619 - JP 2018536436-A/6455: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA874618 - JP 2018536436-A/6454: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA874617 - JP 2018536436-A/6453: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA874613 - JP 2018536436-A/6449: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA874612 - JP 2018536436-A/6448: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA874589 - JP 2018536436-A/6425: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA874588 - JP 2018536436-A/6424: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA874587 - JP 2018536436-A/6423: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA874586 - JP 2018536436-A/6422: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA874876 - JP 2018536436-A/6712: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA874585 - JP 2018536436-A/6421: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA874875 - JP 2018536436-A/6711: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA874584 - JP 2018536436-A/6420: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA874874 - JP 2018536436-A/6710: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA874583 - JP 2018536436-A/6419: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA874872 - JP 2018536436-A/6708: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA874582 - JP 2018536436-A/6418: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA874865 - JP 2018536436-A/6701: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA874581 - JP 2018536436-A/6417: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA874863 - JP 2018536436-A/6699: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA874580 - JP 2018536436-A/6416: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA874862 - JP 2018536436-A/6698: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA874579 - JP 2018536436-A/6415: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA874860 - JP 2018536436-A/6696: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA874578 - JP 2018536436-A/6414: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA874567 - JP 2018536436-A/6403: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA874853 - JP 2018536436-A/6689: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA874566 - JP 2018536436-A/6402: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA874852 - JP 2018536436-A/6688: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA874565 - JP 2018536436-A/6401: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA874851 - JP 2018536436-A/6687: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA874564 - JP 2018536436-A/6400: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA874850 - JP 2018536436-A/6686: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA874563 - JP 2018536436-A/6399: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA874849 - JP 2018536436-A/6685: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA874562 - JP 2018536436-A/6398: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA874848 - JP 2018536436-A/6684: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA874561 - JP 2018536436-A/6397: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA874847 - JP 2018536436-A/6683: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA874560 - JP 2018536436-A/6396: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA874846 - JP 2018536436-A/6682: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA874559 - JP 2018536436-A/6395: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA874843 - JP 2018536436-A/6679: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA874558 - JP 2018536436-A/6394: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA874839 - JP 2018536436-A/6675: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA874557 - JP 2018536436-A/6393: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA874838 - JP 2018536436-A/6674: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA874556 - JP 2018536436-A/6392: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA874837 - JP 2018536436-A/6673: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA874555 - JP 2018536436-A/6391: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA874541 - JP 2018536436-A/6377: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA874540 - JP 2018536436-A/6376: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA874539 - JP 2018536436-A/6375: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA874538 - JP 2018536436-A/6374: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA874537 - JP 2018536436-A/6373: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA874832 - JP 2018536436-A/6668: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA874536 - JP 2018536436-A/6372: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA874827 - JP 2018536436-A/6663: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA874535 - JP 2018536436-A/6371: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA874509 - JP 2018536436-A/6345: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA874508 - JP 2018536436-A/6344: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA874821 - JP 2018536436-A/6657: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA874507 - JP 2018536436-A/6343: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA874818 - JP 2018536436-A/6654: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA874506 - JP 2018536436-A/6342: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA874816 - JP 2018536436-A/6652: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA874505 - JP 2018536436-A/6341: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA874814 - JP 2018536436-A/6650: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA874504 - JP 2018536436-A/6340: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA874813 - JP 2018536436-A/6649: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA874503 - JP 2018536436-A/6339: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY597073 - KR 1020180133840-A/6497: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY597072 - KR 1020180133840-A/6496: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY597071 - KR 1020180133840-A/6495: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY597070 - KR 1020180133840-A/6494: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY597069 - KR 1020180133840-A/6493: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY597068 - KR 1020180133840-A/6492: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY597067 - KR 1020180133840-A/6491: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY597066 - KR 1020180133840-A/6490: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY597065 - KR 1020180133840-A/6489: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY597064 - KR 1020180133840-A/6488: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY597063 - KR 1020180133840-A/6487: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY597062 - KR 1020180133840-A/6486: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY597061 - KR 1020180133840-A/6485: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY597060 - KR 1020180133840-A/6484: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY597059 - KR 1020180133840-A/6483: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY597058 - KR 1020180133840-A/6482: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY597057 - KR 1020180133840-A/6481: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY597056 - KR 1020180133840-A/6480: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY597055 - KR 1020180133840-A/6479: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY597054 - KR 1020180133840-A/6478: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY597053 - KR 1020180133840-A/6477: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY597052 - KR 1020180133840-A/6476: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY597051 - KR 1020180133840-A/6475: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY597050 - KR 1020180133840-A/6474: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY597049 - KR 1020180133840-A/6473: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY597048 - KR 1020180133840-A/6472: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY597047 - KR 1020180133840-A/6471: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY597046 - KR 1020180133840-A/6470: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY597044 - KR 1020180133840-A/6468: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY597043 - KR 1020180133840-A/6467: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY597042 - KR 1020180133840-A/6466: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY597041 - KR 1020180133840-A/6465: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY597040 - KR 1020180133840-A/6464: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY597039 - KR 1020180133840-A/6463: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY597038 - KR 1020180133840-A/6462: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY597037 - KR 1020180133840-A/6461: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY597036 - KR 1020180133840-A/6460: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY597035 - KR 1020180133840-A/6459: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY597034 - KR 1020180133840-A/6458: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY597033 - KR 1020180133840-A/6457: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY597032 - KR 1020180133840-A/6456: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY597031 - KR 1020180133840-A/6455: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY597030 - KR 1020180133840-A/6454: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY597029 - KR 1020180133840-A/6453: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY597025 - KR 1020180133840-A/6449: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY597024 - KR 1020180133840-A/6448: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY597001 - KR 1020180133840-A/6425: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY597000 - KR 1020180133840-A/6424: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY596999 - KR 1020180133840-A/6423: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY596998 - KR 1020180133840-A/6422: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY597288 - KR 1020180133840-A/6749: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY596997 - KR 1020180133840-A/6421: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY597287 - KR 1020180133840-A/6748: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY596996 - KR 1020180133840-A/6420: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY597286 - KR 1020180133840-A/6747: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY596995 - KR 1020180133840-A/6419: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY597284 - KR 1020180133840-A/6745: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY596994 - KR 1020180133840-A/6418: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY597277 - KR 1020180133840-A/6738: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY596993 - KR 1020180133840-A/6417: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY597275 - KR 1020180133840-A/6736: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY596992 - KR 1020180133840-A/6416: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY597274 - KR 1020180133840-A/6735: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY596991 - KR 1020180133840-A/6415: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY597272 - KR 1020180133840-A/6733: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY596990 - KR 1020180133840-A/6414: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY596979 - KR 1020180133840-A/6403: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY597265 - KR 1020180133840-A/6726: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY596978 - KR 1020180133840-A/6402: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY597264 - KR 1020180133840-A/6725: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY596977 - KR 1020180133840-A/6401: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY597263 - KR 1020180133840-A/6724: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY596976 - KR 1020180133840-A/6400: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY597262 - KR 1020180133840-A/6723: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY596975 - KR 1020180133840-A/6399: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY597261 - KR 1020180133840-A/6722: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY596974 - KR 1020180133840-A/6398: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY597260 - KR 1020180133840-A/6721: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY596973 - KR 1020180133840-A/6397: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY597259 - KR 1020180133840-A/6720: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY596972 - KR 1020180133840-A/6396: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY597258 - KR 1020180133840-A/6719: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY596971 - KR 1020180133840-A/6395: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY597255 - KR 1020180133840-A/6716: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY596970 - KR 1020180133840-A/6394: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY597251 - KR 1020180133840-A/6712: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY596969 - KR 1020180133840-A/6393: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY597250 - KR 1020180133840-A/6711: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY596968 - KR 1020180133840-A/6392: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY597249 - KR 1020180133840-A/6710: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY596967 - KR 1020180133840-A/6391: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY596953 - KR 1020180133840-A/6377: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY596952 - KR 1020180133840-A/6376: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY596951 - KR 1020180133840-A/6375: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY596950 - KR 1020180133840-A/6374: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY596949 - KR 1020180133840-A/6373: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY597244 - KR 1020180133840-A/6705: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY596948 - KR 1020180133840-A/6372: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY597239 - KR 1020180133840-A/6700: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY596947 - KR 1020180133840-A/6371: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY596921 - KR 1020180133840-A/6345: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY596920 - KR 1020180133840-A/6344: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY597233 - KR 1020180133840-A/6694: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY596919 - KR 1020180133840-A/6343: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY597230 - KR 1020180133840-A/6691: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY596918 - KR 1020180133840-A/6342: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY597228 - KR 1020180133840-A/6689: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY596917 - KR 1020180133840-A/6341: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY597226 - KR 1020180133840-A/6687: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY596916 - KR 1020180133840-A/6340: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY597225 - KR 1020180133840-A/6686: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY596915 - KR 1020180133840-A/6339: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein P62942 (Reactome details) participates in the following event(s):
R-HSA-170846 TGFBR2 recruits TGFBR1 R-HSA-2134519 TGFBR2 is recruited to tight junctions after TGF-beta stimulation R-HSA-3645786 TGFBR2 mutant dimers recruit TGFBR1 R-HSA-3656484 TGFBR2 recruits TGFBR1 KD Mutants R-HSA-2134506 TGFBR1 is recruited to tight junctions by PARD6A R-HSA-2173789 TGF-beta receptor signaling activates SMADs R-HSA-2173791 TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-3645790 TGFBR2 Kinase Domain Mutants in Cancer R-HSA-3656532 TGFBR1 KD Mutants in Cancer R-HSA-3656535 TGFBR1 LBD Mutants in Cancer R-HSA-170834 Signaling by TGF-beta Receptor Complex R-HSA-3642278 Loss of Function of TGFBR2 in Cancer R-HSA-3656534 Loss of Function of TGFBR1 in Cancer R-HSA-9006936 Signaling by TGF-beta family members R-HSA-3304351 Signaling by TGF-beta Receptor Complex in Cancer R-HSA-162582 Signal Transduction R-HSA-5663202 Diseases of signal transduction R-HSA-1643685 Disease
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
