Human Gene FKBP3 (ENST00000396062.4_8) from GENCODE V47lift37
  Description: FKBP prolyl isomerase 3 (from RefSeq NM_002013.4)
Gencode Transcript: ENST00000396062.4_8
Gencode Gene: ENSG00000100442.11_10
Transcript (Including UTRs)
   Position: hg19 chr14:45,584,802-45,603,684 Size: 18,883 Total Exon Count: 7 Strand: -
Coding Region
   Position: hg19 chr14:45,585,401-45,603,659 Size: 18,259 Coding Exon Count: 7 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr14:45,584,802-45,603,684)mRNA (may differ from genome)Protein (224 aa)
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BioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: FKBP3_HUMAN
DESCRIPTION: RecName: Full=Peptidyl-prolyl cis-trans isomerase FKBP3; Short=PPIase FKBP3; EC=5.2.1.8; AltName: Full=25 kDa FK506-binding protein; Short=25 kDa FKBP; Short=FKBP-25; AltName: Full=FK506-binding protein 3; Short=FKBP-3; AltName: Full=Immunophilin FKBP25; AltName: Full=Rapamycin-selective 25 kDa immunophilin; AltName: Full=Rotamase;
FUNCTION: FK506- and rapamycin-binding proteins (FKBPs) constitute a family of receptors for the two immunosuppressants which inhibit T-cell proliferation by arresting two distinct cytoplasmic signal transmission pathways. PPIases accelerate the folding of proteins.
CATALYTIC ACTIVITY: Peptidylproline (omega=180) = peptidylproline (omega=0).
ENZYME REGULATION: Inhibited preferentially by rapamycin over FK506.
SUBCELLULAR LOCATION: Nucleus.
SIMILARITY: Belongs to the FKBP-type PPIase family.
SIMILARITY: Contains 1 PPIase FKBP-type domain.
SEQUENCE CAUTION: Sequence=AAA58474.1; Type=Frameshift; Positions=197;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 81.46 RPKM in Muscle - Skeletal
Total median expression: 1616.60 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -1.7025-0.068 Picture PostScript Text
3' UTR -128.00599-0.214 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR023566 - PPIase_FKBP
IPR001179 - PPIase_FKBP_dom

Pfam Domains:
PF00254 - FKBP-type peptidyl-prolyl cis-trans isomerase
PF18410 - Basic tilted helix bundle domain

SCOP Domains:
47819 - HRDC-like
54534 - FKBP-like
55060 - GHMP Kinase, C-terminal domain

Protein Data Bank (PDB) 3-D Structure
MuPIT help
1PBK - X-ray MuPIT 2KFV - NMR MuPIT


ModBase Predicted Comparative 3D Structure on Q00688
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003723 RNA binding
GO:0003755 peptidyl-prolyl cis-trans isomerase activity
GO:0005515 protein binding
GO:0005528 FK506 binding
GO:0016853 isomerase activity
GO:0038023 signaling receptor activity

Biological Process:
GO:0000413 protein peptidyl-prolyl isomerization
GO:0007165 signal transduction
GO:0061077 chaperone-mediated protein folding

Cellular Component:
GO:0005634 nucleus
GO:0005737 cytoplasm


-  Descriptions from all associated GenBank mRNAs
  M90309 - Human FK506-binding protein 25 (FKBP25) mRNA, complete cds.
BC020809 - Homo sapiens FK506 binding protein 3, 25kDa, mRNA (cDNA clone MGC:23847 IMAGE:4292678), complete cds.
BC016288 - Homo sapiens FK506 binding protein 3, 25kDa, mRNA (cDNA clone MGC:9482 IMAGE:3919642), complete cds.
M90820 - Human rapamycin-binding protein (FKBP25) mRNA, complete cds.
M96256 - Human rapamycin binding protein (FK506) mRNA, complete cds.
AK222993 - Homo sapiens mRNA for FK506-binding protein 3 variant, clone: HSI06975.
JD550807 - Sequence 531831 from Patent EP1572962.
JD346137 - Sequence 327161 from Patent EP1572962.
JD240701 - Sequence 221725 from Patent EP1572962.
AK311915 - Homo sapiens cDNA, FLJ92182, Homo sapiens FK506 binding protein 3, 25kDa (FKBP3), mRNA.
KJ891178 - Synthetic construct Homo sapiens clone ccsbBroadEn_00572 FKBP3 gene, encodes complete protein.
BT006904 - Homo sapiens FK506 binding protein 3, 25kDa mRNA, complete cds.
DQ890734 - Synthetic construct clone IMAGE:100003364; FLH165555.01X; RZPDo839D10160D FK506 binding protein 3, 25kDa (FKBP3) gene, encodes complete protein.
DQ891132 - Synthetic construct clone IMAGE:100003762; FLH169605.01X; RZPDo839E0296D FK506 binding protein 3, 25kDa (FKBP3) gene, encodes complete protein.
DQ893906 - Synthetic construct Homo sapiens clone IMAGE:100008366; FLH165551.01L; RZPDo839D10159D FK506 binding protein 3, 25kDa (FKBP3) gene, encodes complete protein.
DQ894311 - Synthetic construct Homo sapiens clone IMAGE:100008771; FLH169601.01L; RZPDo839E0295D FK506 binding protein 3, 25kDa (FKBP3) gene, encodes complete protein.
AB528407 - Synthetic construct DNA, clone: pF1KB6908, Homo sapiens FKBP3 gene for FK506 binding protein 3, 25kDa, without stop codon, in Flexi system.
CU677595 - Synthetic construct Homo sapiens gateway clone IMAGE:100020635 5' read FKBP3 mRNA.
JD436563 - Sequence 417587 from Patent EP1572962.
JD038609 - Sequence 19633 from Patent EP1572962.
JD374734 - Sequence 355758 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: B2R4Q9, ENST00000396062.1, ENST00000396062.2, ENST00000396062.3, FKBP25, FKBP3_HUMAN, NM_002013, Q00688, Q14317, uc318xys.1, uc318xys.2
UCSC ID: ENST00000396062.4_8
RefSeq Accession: NM_002013.4
Protein: Q00688 (aka FKBP3_HUMAN or FKB3_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.