Human Gene FKBP9 (ENST00000242209.9_6) from GENCODE V47lift37
  Description: FKBP prolyl isomerase 9, transcript variant 1 (from RefSeq NM_007270.5)
Gencode Transcript: ENST00000242209.9_6
Gencode Gene: ENSG00000122642.11_10
Transcript (Including UTRs)
   Position: hg19 chr7:32,997,052-33,046,540 Size: 49,489 Total Exon Count: 10 Strand: +
Coding Region
   Position: hg19 chr7:32,997,186-33,044,963 Size: 47,778 Coding Exon Count: 10 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr7:32,997,052-33,046,540)mRNA (may differ from genome)Protein (570 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
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HGNCMGIOMIMPubMedReactomeUniProtKB
WikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: FKBP9_HUMAN
DESCRIPTION: RecName: Full=Peptidyl-prolyl cis-trans isomerase FKBP9; Short=PPIase FKBP9; EC=5.2.1.8; AltName: Full=63 kDa FK506-binding protein; Short=63 kDa FKBP; Short=FKBP-63; AltName: Full=FK506-binding protein 9; Short=FKBP-9; AltName: Full=Rotamase; Flags: Precursor;
FUNCTION: PPIases accelerate the folding of proteins during protein synthesis.
CATALYTIC ACTIVITY: Peptidylproline (omega=180) = peptidylproline (omega=0).
ENZYME REGULATION: Inhibited by FK506 (By similarity).
SUBCELLULAR LOCATION: Endoplasmic reticulum (By similarity).
PTM: Phosphorylated (By similarity).
SIMILARITY: Contains 2 EF-hand domains.
SIMILARITY: Contains 4 PPIase FKBP-type domains.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 62.18 RPKM in Cells - Cultured fibroblasts
Total median expression: 1018.63 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -60.40134-0.451 Picture PostScript Text
3' UTR -485.301577-0.308 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR011992 - EF-hand-like_dom
IPR018247 - EF_Hand_1_Ca_BS
IPR018249 - EF_HAND_2
IPR002048 - EF_hand_Ca-bd
IPR023566 - PPIase_FKBP
IPR001179 - PPIase_FKBP_dom

Pfam Domains:
PF00254 - FKBP-type peptidyl-prolyl cis-trans isomerase
PF13202 - EF hand

SCOP Domains:
47473 - EF-hand
141300 - GatD N-terminal domain-like
54534 - FKBP-like

ModBase Predicted Comparative 3D Structure on O95302
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologGenome BrowserNo ortholog
Gene DetailsGene Details  Gene Details 
Gene SorterGene Sorter  Gene Sorter 
 RGDEnsembl WormBase 
    Protein Sequence 
    Alignment 

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003755 peptidyl-prolyl cis-trans isomerase activity
GO:0005509 calcium ion binding
GO:0005528 FK506 binding
GO:0016853 isomerase activity
GO:0046872 metal ion binding

Biological Process:
GO:0000413 protein peptidyl-prolyl isomerization
GO:0006457 protein folding
GO:0061077 chaperone-mediated protein folding

Cellular Component:
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum


-  Descriptions from all associated GenBank mRNAs
  AK075331 - Homo sapiens cDNA PSEC0007 fis, clone NT2RM1000634, highly similar to FK506-binding protein 9 precursor (EC 5.2.1.8).
AK300328 - Homo sapiens cDNA FLJ51089 complete cds, highly similar to FK506-binding protein 9 precursor (EC 5.2.1.8).
AK128597 - Homo sapiens cDNA FLJ46756 fis, clone TRACH3023516, highly similar to FK506-binding protein 9 precursor (EC 5.2.1.8).
AK293954 - Homo sapiens cDNA FLJ53831 complete cds, highly similar to FK506-binding protein 9 precursor (EC 5.2.1.8).
AK294266 - Homo sapiens cDNA FLJ53833 complete cds, highly similar to FK506-binding protein 9 precursor (EC 5.2.1.8).
BC101723 - Homo sapiens FK506 binding protein 9, 63 kDa, mRNA (cDNA clone MGC:126772 IMAGE:8069229), complete cds.
BC112053 - Homo sapiens FK506 binding protein 9, 63 kDa, mRNA (cDNA clone MGC:138258 IMAGE:8327521), complete cds.
KJ893279 - Synthetic construct Homo sapiens clone ccsbBroadEn_02673 FKBP9 gene, encodes complete protein.
AF089745 - Homo sapiens FK506-binding protein (FKBP63) mRNA, partial cds.
AK304643 - Homo sapiens cDNA FLJ51199 complete cds, highly similar to FK506-binding protein 9 precursor (EC5.2.1.8).
AK293440 - Homo sapiens cDNA FLJ55188 complete cds, highly similar to FK506-binding protein 9 precursor (EC 5.2.1.8).
BC064418 - Homo sapiens FK506 binding protein 9, 63 kDa, mRNA (cDNA clone IMAGE:5750487), partial cds.
AK316290 - Homo sapiens cDNA, FLJ79189 complete cds, highly similar to FK506-binding protein 9 precursor (EC 5.2.1.8).
BC127737 - Homo sapiens cDNA clone IMAGE:40127336.
BC150541 - Homo sapiens cDNA clone IMAGE:40127337.
BC150542 - Homo sapiens cDNA clone IMAGE:40127338.
AB209352 - Homo sapiens mRNA for FK506 binding protein 9 variant protein.
BC007443 - Homo sapiens FK506 binding protein 9, 63 kDa, mRNA (cDNA clone IMAGE:2963618), partial cds.
BC072422 - Homo sapiens FK506 binding protein 9, 63 kDa, mRNA (cDNA clone IMAGE:6185382), partial cds.
BC099918 - Homo sapiens FK506 binding protein 9, 63 kDa, mRNA (cDNA clone IMAGE:6646909), partial cds.
AL050187 - Homo sapiens mRNA; cDNA DKFZp586B1723 (from clone DKFZp586B1723).
JD404381 - Sequence 385405 from Patent EP1572962.
JD229517 - Sequence 210541 from Patent EP1572962.
JD333921 - Sequence 314945 from Patent EP1572962.
JD121699 - Sequence 102723 from Patent EP1572962.
JD111232 - Sequence 92256 from Patent EP1572962.
JD559966 - Sequence 540990 from Patent EP1572962.
JD353087 - Sequence 334111 from Patent EP1572962.
JD370153 - Sequence 351177 from Patent EP1572962.
JD258823 - Sequence 239847 from Patent EP1572962.
JD152346 - Sequence 133370 from Patent EP1572962.
JD256846 - Sequence 237870 from Patent EP1572962.
JD213336 - Sequence 194360 from Patent EP1572962.
JD488018 - Sequence 469042 from Patent EP1572962.
JD444497 - Sequence 425521 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein O95302 (Reactome details) participates in the following event(s):

R-HSA-390470 Association of CCT/TriC with other substrates during biosynthesis (unknown chaperone)
R-HSA-390471 Association of TriC/CCT with target proteins during biosynthesis
R-HSA-390466 Chaperonin-mediated protein folding
R-HSA-391251 Protein folding
R-HSA-392499 Metabolism of proteins

-  Other Names for This Gene
  Alternate Gene Symbols: B3KY35, B7Z1G9, B7Z6H3, ENST00000242209.1, ENST00000242209.2, ENST00000242209.3, ENST00000242209.4, ENST00000242209.5, ENST00000242209.6, ENST00000242209.7, ENST00000242209.8, FKBP60, FKBP63, FKBP9_HUMAN, NM_007270, O95302, Q2M2A1, Q3MIR7, Q6IN76, Q6P2N1, Q96EX5, Q96IJ9, uc317ejs.1, uc317ejs.2
UCSC ID: ENST00000242209.9_6
RefSeq Accession: NM_007270.5
Protein: O95302 (aka FKBP9_HUMAN or FKB9_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.