Human Gene FLOT1 (ENST00000376389.8_7) from GENCODE V47lift37
  Description: flotillin 1, transcript variant 1 (from RefSeq NM_005803.4)
Gencode Transcript: ENST00000376389.8_7
Gencode Gene: ENSG00000137312.15_15
Transcript (Including UTRs)
   Position: hg19 chr6:30,695,486-30,710,464 Size: 14,979 Total Exon Count: 13 Strand: -
Coding Region
   Position: hg19 chr6:30,695,893-30,709,966 Size: 14,074 Coding Exon Count: 12 

Page IndexSequence and LinksPrimersMalaCardsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr6:30,695,486-30,710,464)mRNA (may differ from genome)Protein (427 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedUniProtKB
WikipediaBioGrid CRISPR DB

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: FLOT1
Diseases sorted by gene-association score: mycobacterium marinum (4)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 207.09 RPKM in Whole Blood
Total median expression: 4351.44 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -89.10175-0.509 Picture PostScript Text
3' UTR -96.00407-0.236 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001107 - Band_7

Pfam Domains:
PF01145 - SPFH domain / Band 7 family

SCOP Domains:
117892 - Band 7/SPFH domain

ModBase Predicted Comparative 3D Structure on Q5ST80
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details Gene Details  
Gene SorterGene Sorter Gene Sorter  
 RGDEnsembl   
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0002020 protease binding
GO:0035255 ionotropic glutamate receptor binding

Biological Process:
GO:0002090 regulation of receptor internalization
GO:0007409 axonogenesis
GO:0032092 positive regulation of protein binding
GO:0032226 positive regulation of synaptic transmission, dopaminergic
GO:0035023 regulation of Rho protein signal transduction
GO:0045807 positive regulation of endocytosis
GO:0048643 positive regulation of skeletal muscle tissue development
GO:0070528 protein kinase C signaling
GO:0072659 protein localization to plasma membrane
GO:1901741 positive regulation of myoblast fusion
GO:1901890 positive regulation of cell junction assembly
GO:2000049 positive regulation of cell-cell adhesion mediated by cadherin

Cellular Component:
GO:0005765 lysosomal membrane
GO:0005886 plasma membrane
GO:0005901 caveola
GO:0016020 membrane
GO:0016600 flotillin complex
GO:0042383 sarcolemma
GO:0044853 plasma membrane raft
GO:0045121 membrane raft


-  Descriptions from all associated GenBank mRNAs
  AF117234 - Homo sapiens flotillin mRNA, complete cds.
AF089750 - Homo sapiens flotillin-1 mRNA, complete cds.
JD248170 - Sequence 229194 from Patent EP1572962.
BC001146 - Homo sapiens flotillin 1, mRNA (cDNA clone MGC:1199 IMAGE:3534771), complete cds.
AF085357 - Homo sapiens flotillin mRNA, complete cds.
AK000816 - Homo sapiens cDNA FLJ20809 fis, clone ADSE01728, highly similar to AF089750 Homo sapiens flotillin-1 mRNA.
AK222530 - Homo sapiens mRNA for flotillin 1 variant, clone: adSE01728.
JD267452 - Sequence 248476 from Patent EP1572962.
JD071422 - Sequence 52446 from Patent EP1572962.
JD380346 - Sequence 361370 from Patent EP1572962.
BC128154 - Homo sapiens flotillin 1, mRNA (cDNA clone IMAGE:40112645), partial cds.
JD380217 - Sequence 361241 from Patent EP1572962.
JD188667 - Sequence 169691 from Patent EP1572962.
JD533767 - Sequence 514791 from Patent EP1572962.
AK301291 - Homo sapiens cDNA FLJ54943 complete cds, highly similar to Flotillin-1.
JD338457 - Sequence 319481 from Patent EP1572962.
JD541748 - Sequence 522772 from Patent EP1572962.
JD350900 - Sequence 331924 from Patent EP1572962.
KJ892961 - Synthetic construct Homo sapiens clone ccsbBroadEn_02355 FLOT1 gene, encodes complete protein.
BT007077 - Homo sapiens flotillin 1 mRNA, complete cds.
DQ890639 - Synthetic construct clone IMAGE:100003269; FLH164677.01X; RZPDo839A07158D flotillin 1 (FLOT1) gene, encodes complete protein.
DQ893815 - Synthetic construct Homo sapiens clone IMAGE:100008275; FLH164673.01L; RZPDo839A07157D flotillin 1 (FLOT1) gene, encodes complete protein.
AB528496 - Synthetic construct DNA, clone: pF1KB6681, Homo sapiens FLOT1 gene for flotillin 1, without stop codon, in Flexi system.
CR456946 - Homo sapiens full open reading frame cDNA clone RZPDo834H1118D for gene FLOT1, flotillin 1; complete cds, incl. stopcodon.
CU674578 - Synthetic construct Homo sapiens gateway clone IMAGE:100017247 5' read FLOT1 mRNA.
JD437071 - Sequence 418095 from Patent EP1572962.
JD230851 - Sequence 211875 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000376389.1, ENST00000376389.2, ENST00000376389.3, ENST00000376389.4, ENST00000376389.5, ENST00000376389.6, ENST00000376389.7, FLOT1 , hCG_2006678 , NM_005803, Q5ST80, Q5ST80_HUMAN, uc318mxj.1, uc318mxj.2
UCSC ID: ENST00000376389.8_7
RefSeq Accession: NM_005803.4
Protein: Q5ST80

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.