ID:FLOT2_HUMAN DESCRIPTION: RecName: Full=Flotillin-2; AltName: Full=Epidermal surface antigen; Short=ESA; AltName: Full=Membrane component chromosome 17 surface marker 1; FUNCTION: May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles. May be involved in epidermal cell adhesion and epidermal structure and function. SUBUNIT: Heterooligomeric complex of flotillin-1 and flotillin-2 and caveolin-1 and caveolin-2 (By similarity). Interacts with ECM29. SUBCELLULAR LOCATION: Cell membrane; Peripheral membrane protein. Membrane, caveola; Peripheral membrane protein. Endosome. Note=Membrane-associated protein of caveolae. TISSUE SPECIFICITY: In skin, expressed in epidermis and epidermal appendages but not in dermis. Expressed in all layers of the epidermis except the basal layer. In hair follicles, expressed in the suprabasal layer but not the basal layer. Also expressed in melanoma and carcinoma cell lines, fibroblasts and foreskin melanocytes. PTM: ZDHHC5-catalyzed palmitoylation predominantly occurs at Cys- 4. ZDHHC5-catalyzed palmitoylation may be required for the formation of higher-order complexes and for neurite outgrowth in cultured neural stem cells. SIMILARITY: Belongs to the band 7/mec-2 family. Flotillin subfamily. SEQUENCE CAUTION: Sequence=AAA65729.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q14254
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0002020 protease binding GO:0005515 protein binding GO:0035255 ionotropic glutamate receptor binding GO:0046982 protein heterodimerization activity
Biological Process: GO:0001765 membrane raft assembly GO:0007155 cell adhesion GO:0008544 epidermis development GO:0010629 negative regulation of gene expression GO:0044860 protein localization to plasma membrane raft GO:0045661 regulation of myoblast differentiation GO:0050821 protein stabilization GO:0072659 protein localization to plasma membrane GO:1902992 negative regulation of amyloid precursor protein catabolic process GO:1903905 positive regulation of establishment of T cell polarity GO:0034114 regulation of heterotypic cell-cell adhesion GO:0034139 regulation of toll-like receptor 3 signaling pathway
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
