Human Gene FLT3LG (ENST00000597551.6_4) from GENCODE V47lift37
  Description: fms related receptor tyrosine kinase 3 ligand, transcript variant 3 (from RefSeq NM_001459.4)
Gencode Transcript: ENST00000597551.6_4
Gencode Gene: ENSG00000090554.13_8
Transcript (Including UTRs)
   Position: hg19 chr19:49,977,472-49,989,488 Size: 12,017 Total Exon Count: 9 Strand: +
Coding Region
   Position: hg19 chr19:49,977,897-49,983,856 Size: 5,960 Coding Exon Count: 7 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr19:49,977,472-49,989,488)mRNA (may differ from genome)Protein (235 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
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HGNCMalacardsMGIOMIMPubMedReactome
UniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: FLT3L_HUMAN
DESCRIPTION: RecName: Full=Fms-related tyrosine kinase 3 ligand; Short=Flt3 ligand; Short=Flt3L; AltName: Full=SL cytokine; Flags: Precursor;
FUNCTION: Stimulates the proliferation of early hematopoietic cells by activating FLT3. Synergizes well with a number of other colony stimulating factors and interleukins.
SUBUNIT: Homodimer (isoform 2).
SUBCELLULAR LOCATION: Isoform 1: Cell membrane; Single-pass type I membrane protein.
SUBCELLULAR LOCATION: Isoform 2: Secreted.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: FLT3LG
Diseases sorted by gene-association score: aplastic anemia (3)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 6.45 RPKM in Cervix - Endocervix
Total median expression: 151.30 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -45.20104-0.435 Picture PostScript Text
3' UTR -70.20238-0.295 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR009079 - 4_helix_cytokine-like_core
IPR012351 - 4_helix_cytokine_core
IPR004213 - Flt3_lig

Pfam Domains:
PF02947 - flt3 ligand

SCOP Domains:
47266 - 4-helical cytokines

Protein Data Bank (PDB) 3-D Structure
MuPIT help
1ETE - X-ray MuPIT 3QS7 - X-ray MuPIT 3QS9 - X-ray MuPIT


ModBase Predicted Comparative 3D Structure on P49771
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005102 receptor binding
GO:0005125 cytokine activity
GO:0030971 receptor tyrosine kinase binding
GO:0042803 protein homodimerization activity

Biological Process:
GO:0001934 positive regulation of protein phosphorylation
GO:0007165 signal transduction
GO:0008284 positive regulation of cell proliferation
GO:0010469 regulation of receptor activity
GO:0019221 cytokine-mediated signaling pathway
GO:0030098 lymphocyte differentiation
GO:0030885 regulation of myeloid dendritic cell activation
GO:0032819 positive regulation of natural killer cell proliferation
GO:0032825 positive regulation of natural killer cell differentiation
GO:0035162 embryonic hemopoiesis
GO:0045663 positive regulation of myoblast differentiation
GO:0045787 positive regulation of cell cycle
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048873 homeostasis of number of cells within a tissue
GO:0071864 positive regulation of cell proliferation in bone marrow
GO:0071866 negative regulation of apoptotic process in bone marrow
GO:0090290 positive regulation of osteoclast proliferation
GO:1901741 positive regulation of myoblast fusion

Cellular Component:
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005886 plasma membrane
GO:0009986 cell surface
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0031233 intrinsic component of external side of plasma membrane


-  Descriptions from all associated GenBank mRNAs
  U04806 - Human FLT3/FLK2 ligand mRNA, complete cds.
BC006331 - Homo sapiens fms-related tyrosine kinase 3 ligand, mRNA (cDNA clone IMAGE:4299619), complete cds.
BC011914 - Homo sapiens fms-related tyrosine kinase 3 ligand, mRNA (cDNA clone IMAGE:4299278), complete cds.
BC028001 - Homo sapiens fms-related tyrosine kinase 3 ligand, mRNA (cDNA clone MGC:40023 IMAGE:5198812), complete cds.
JD125501 - Sequence 106525 from Patent EP1572962.
BC126293 - Homo sapiens fms-related tyrosine kinase 3 ligand, mRNA (cDNA clone MGC:161571 IMAGE:8992009), complete cds.
BC136464 - Homo sapiens fms-related tyrosine kinase 3 ligand, mRNA (cDNA clone MGC:168076 IMAGE:9020453), complete cds.
BC144129 - Homo sapiens fms-related tyrosine kinase 3 ligand, mRNA (cDNA clone MGC:177666 IMAGE:9052649), complete cds.
U03858 - Human flt3 ligand mRNA, complete cds.
AK301136 - Homo sapiens cDNA FLJ61175 complete cds, highly similar to SL cytokine precursor.
JD168281 - Sequence 149305 from Patent EP1572962.
HQ258599 - Synthetic construct Homo sapiens clone IMAGE:100073141 fms-related tyrosine kinase 3 ligand (FLT3LG) gene, encodes complete protein.
AK308939 - Homo sapiens cDNA, FLJ98980.
JD173071 - Sequence 154095 from Patent EP1572962.
JD205448 - Sequence 186472 from Patent EP1572962.
JD142900 - Sequence 123924 from Patent EP1572962.
MP518010 - Sequence 32 from Patent WO2020041655.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein P49771 (Reactome details) participates in the following event(s):

R-HSA-6786789 FLT3LG dimer binds FLT3
R-HSA-8854736 FLT3LG dimer:FLT3 binds FLT3
R-HSA-449836 Other interleukin signaling
R-HSA-449147 Signaling by Interleukins
R-HSA-1280215 Cytokine Signaling in Immune system
R-HSA-168256 Immune System

-  Other Names for This Gene
  Alternate Gene Symbols: A0AVC2, B9EGH2, ENST00000597551.1, ENST00000597551.2, ENST00000597551.3, ENST00000597551.4, ENST00000597551.5, FLT3L_HUMAN, NM_001459, P49771, Q05C96, uc327cik.1, uc327cik.2
UCSC ID: ENST00000597551.6_4
RefSeq Accession: NM_001459.4
Protein: P49771 (aka FLT3L_HUMAN or FL3L_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.