Human Gene FN1 (ENST00000354785.11_13) from GENCODE V47lift37
  Description: fibronectin 1, transcript variant 1 (from RefSeq NM_212482.4)
Gencode Transcript: ENST00000354785.11_13
Gencode Gene: ENSG00000115414.21_17
Transcript (Including UTRs)
   Position: hg19 chr2:216,225,588-216,300,791 Size: 75,204 Total Exon Count: 46 Strand: -
Coding Region
   Position: hg19 chr2:216,226,278-216,300,525 Size: 74,248 Coding Exon Count: 46 

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Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesGeneReviewsModel Information
Methods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr2:216,225,588-216,300,791)mRNA (may differ from genome)Protein (2477 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsHGNC
MalacardsMGIOMIMPubMedReactomeUniProtKB
WikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: FINC_HUMAN
DESCRIPTION: RecName: Full=Fibronectin; Short=FN; AltName: Full=Cold-insoluble globulin; Short=CIG; Contains: RecName: Full=Anastellin; Contains: RecName: Full=Ugl-Y1; Contains: RecName: Full=Ugl-Y2; Contains: RecName: Full=Ugl-Y3; Flags: Precursor;
FUNCTION: Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape.
FUNCTION: Anastellin binds fibronectin and induces fibril formation. This fibronectin polymer, named superfibronectin, exhibits enhanced adhesive properties. Both anastellin and superfibronectin inhibit tumor growth, angiogenesis and metastasis. Anastellin activates p38 MAPK and inhibits lysophospholipid signaling.
SUBUNIT: Mostly heterodimers or multimers of alternatively spliced variants, connected by 2 disulfide bonds near the carboxyl ends; to a lesser extent homodimers. Interacts with FBLN1, AMBP, TNR, LGALS3BP and COL13A1. Interacts with FBLN7 (By similarity). Interacts with COMP. Interacts with S.aureus fnbA. Interacts with TNR; the interaction inhibits cell adhesion and neurite outgrowth (By similarity). Interacts with FST3.
SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix.
TISSUE SPECIFICITY: Plasma FN (soluble dimeric form) is secreted by hepatocytes. Cellular FN (dimeric or cross-linked multimeric forms), made by fibroblasts, epithelial and other cell types, is deposited as fibrils in the extracellular matrix. Ugl-Y1, Ugl-Y2 and Ugl-Y3 are found in urine.
DEVELOPMENTAL STAGE: Ugl-Y1, Ugl-Y2 and Ugl-Y3 are present in the urine from 0 to 17 years of age.
PTM: Sulfated.
PTM: It is not known whether both or only one of Thr-2064 and Thr- 2065 are/is glycosylated.
PTM: Forms covalent cross-links mediated by a transglutaminase, such as F13A or TGM2, between a glutamine and the epsilon-amino group of a lysine residue, forming homopolymers and heteropolymers (e.g. fibrinogen-fibronectin, collagen-fibronectin heteropolymers).
PTM: Phosphorylation sites are present in the extracellular medium.
PTM: Proteolytic processing produces the C-terminal NC1 peptide, anastellin.
DISEASE: Defects in FN1 are the cause of glomerulopathy with fibronectin deposits type 2 (GFND2) [MIM:601894]; also known as familial glomerular nephritis with fibronectin deposits or fibronectin glomerulopathy. GFND is a genetically heterogeneous autosomal dominant disorder characterized clinically by proteinuria, microscopic hematuria, and hypertension that leads to end-stage renal failure in the second to fifth decade of life.
SIMILARITY: Contains 12 fibronectin type-I domains.
SIMILARITY: Contains 2 fibronectin type-II domains.
SIMILARITY: Contains 16 fibronectin type-III domains.
SEQUENCE CAUTION: Sequence=AAX76513.1; Type=Erroneous gene model prediction; Sequence=BAD93077.1; Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=CAD91166.1; Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=CAD97964.1; Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=CAD97965.1; Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=CAH18136.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
WEB RESOURCE: Name=Wikipedia; Note=Fibronectin entry; URL="http://en.wikipedia.org/wiki/Fibronectin";

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: FN1
Diseases sorted by gene-association score: glomerulopathy with fibronectin deposits 2* (1680), plasma fibronectin deficiency* (50), mycobacterium kansasii (10), cryofibrinogenemia (10), villous adenocarcinoma (9), calciphylaxis (8), type ii mixed cryoglobulinemia (8), waardenburg's syndrome (8), secondary syphilis (8), weber syndrome (7), syphilis (5), non-secretory myeloma (5), arcus senilis (4), multiple myeloma (3), lung cancer (3), end stage renal failure (3), differentiated thyroid carcinoma (3), colorectal cancer (1)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 6937.32 RPKM in Cells - Cultured fibroblasts
Total median expression: 12832.76 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -114.60266-0.431 Picture PostScript Text
3' UTR -166.00690-0.241 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR016060 - Complement_control_module
IPR000083 - Fibronectin_type1
IPR003961 - Fibronectin_type3
IPR000562 - FN_type2_col-bd
IPR013783 - Ig-like_fold
IPR013806 - Kringle-like

Pfam Domains:
PF00039 - Fibronectin type I domain
PF00040 - Fibronectin type II domain
PF00041 - Fibronectin type III domain

SCOP Domains:
49363 - Purple acid phosphatase, N-terminal domain
49265 - Fibronectin type III
141658 - Bacteriophage trimeric proteins domain
57440 - Kringle-like
57603 - FnI-like domain

Protein Data Bank (PDB) 3-D Structure
MuPIT help
1E88 - NMR 1E8B - NMR 1FBR - NMR 1FNA - X-ray 1FNF - X-ray 1FNH - X-ray 1J8K - NMR 1O9A - NMR 1OWW - NMR 1Q38 - NMR 1QGB - NMR 1QO6 - NMR 1TTF - NMR 1TTG - NMR 2CG6 - X-ray 2CG7 - X-ray 2CK2 - X-ray 2CKU - NMR 2EC3 - NMR 2FN2 - NMR 2FNB - NMR 2GEE - X-ray 2H41 - NMR 2H45 - NMR 2HA1 - NMR 2OCF - X-ray MuPIT 2RKY - X-ray 2RKZ - X-ray 2RL0 - X-ray 3CAL - X-ray 3EJH - X-ray MuPIT 3GXE - X-ray MuPIT 3M7P - X-ray 3MQL - X-ray 3R8Q - X-ray 3ZRZ - X-ray


ModBase Predicted Comparative 3D Structure on P02751
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-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGDEnsembl   
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0002020 protease binding
GO:0005102 receptor binding
GO:0005178 integrin binding
GO:0005515 protein binding
GO:0005518 collagen binding
GO:0008022 protein C-terminus binding
GO:0008201 heparin binding
GO:0016504 peptidase activator activity
GO:0019899 enzyme binding
GO:0042802 identical protein binding
GO:0051087 chaperone binding
GO:0097718 disordered domain specific binding

Biological Process:
GO:0001525 angiogenesis
GO:0001932 regulation of protein phosphorylation
GO:0002576 platelet degranulation
GO:0006953 acute-phase response
GO:0007044 cell-substrate junction assembly
GO:0007155 cell adhesion
GO:0007160 cell-matrix adhesion
GO:0007161 calcium-independent cell-matrix adhesion
GO:0008284 positive regulation of cell proliferation
GO:0008360 regulation of cell shape
GO:0009611 response to wounding
GO:0010628 positive regulation of gene expression
GO:0010952 positive regulation of peptidase activity
GO:0018149 peptide cross-linking
GO:0019221 cytokine-mediated signaling pathway
GO:0030198 extracellular matrix organization
GO:0033622 integrin activation
GO:0034446 substrate adhesion-dependent cell spreading
GO:0035987 endodermal cell differentiation
GO:0042060 wound healing
GO:0043687 post-translational protein modification
GO:0044267 cellular protein metabolic process
GO:0045773 positive regulation of axon extension
GO:0048146 positive regulation of fibroblast proliferation
GO:0050900 leukocyte migration
GO:0051702 interaction with symbiont
GO:0052047 interaction with other organism via secreted substance involved in symbiotic interaction
GO:0070372 regulation of ERK1 and ERK2 cascade
GO:1904237 positive regulation of substrate-dependent cell migration, cell attachment to substrate
GO:2001202 negative regulation of transforming growth factor-beta secretion

Cellular Component:
GO:0005576 extracellular region
GO:0005577 fibrinogen complex
GO:0005604 basement membrane
GO:0005605 basal lamina
GO:0005615 extracellular space
GO:0005788 endoplasmic reticulum lumen
GO:0005793 endoplasmic reticulum-Golgi intermediate compartment
GO:0016324 apical plasma membrane
GO:0031012 extracellular matrix
GO:0031093 platelet alpha granule lumen
GO:0070062 extracellular exosome
GO:0072562 blood microparticle


-  Descriptions from all associated GenBank mRNAs
  CR749317 - Homo sapiens mRNA; cDNA DKFZp686H0342 (from clone DKFZp686H0342).
LF205234 - JP 2014500723-A/12737: Polycomb-Associated Non-Coding RNAs.
BX640999 - Homo sapiens mRNA; cDNA DKFZp686O12165 (from clone DKFZp686O12165); complete cds.
E01162 - cDNA encoding human fibronectin.
AL832202 - Homo sapiens mRNA; cDNA DKFZp686H112 (from clone DKFZp686H112).
CR749281 - Homo sapiens mRNA; cDNA DKFZp686F10164 (from clone DKFZp686F10164).
X02761 - Human mRNA for fibronectin (FN precursor).
CR749316 - Homo sapiens mRNA; cDNA DKFZp686K08164 (from clone DKFZp686K08164).
BC078656 - Homo sapiens cDNA clone IMAGE:30347017, containing frame-shift errors.
BC100030 - Homo sapiens cDNA clone IMAGE:30343682, containing frame-shift errors.
BX538017 - Homo sapiens mRNA; cDNA DKFZp686O016 (from clone DKFZp686O016).
BX538018 - Homo sapiens mRNA; cDNA DKFZp686E169 (from clone DKFZp686E169).
BX640731 - Homo sapiens mRNA; cDNA DKFZp686M2451 (from clone DKFZp686M2451); complete cds.
BX640802 - Homo sapiens mRNA; cDNA DKFZp686F219 (from clone DKFZp686F219); complete cds.
BX640803 - Homo sapiens mRNA; cDNA DKFZp686O1570 (from clone DKFZp686O1570).
BX649182 - Homo sapiens mRNA; cDNA DKFZp686K139 (from clone DKFZp686K139); complete cds.
AB209840 - Homo sapiens mRNA for Fibronectin 1 variant protein.
AB191261 - Homo sapiens FN1 mRNA for fibronectin 1, complete cds.
AL832771 - Homo sapiens mRNA; cDNA DKFZp686B197 (from clone DKFZp686B197).
BX537590 - Homo sapiens mRNA; cDNA DKFZp686I155 (from clone DKFZp686I155).
BX640608 - Homo sapiens mRNA; cDNA DKFZp686M04163 (from clone DKFZp686M04163).
BX640875 - Homo sapiens mRNA; cDNA DKFZp686O1166 (from clone DKFZp686O1166).
BC117176 - Homo sapiens fibronectin 1, mRNA (cDNA clone MGC:150785 IMAGE:40125727), complete cds.
BC143754 - Homo sapiens fibronectin 1, mRNA (cDNA clone MGC:177285 IMAGE:9052268), complete cds.
BC143763 - Homo sapiens fibronectin 1, mRNA (cDNA clone MGC:177294 IMAGE:9052277), complete cds.
GQ891409 - Homo sapiens clone HEL-S-128 epididymis secretory sperm binding protein mRNA, complete cds.
EU831936 - Synthetic construct Homo sapiens clone HAIB:100066965; DKFZo008D0123 fibronectin 1 protein (FN1) gene, encodes complete protein.
EU832031 - Synthetic construct Homo sapiens clone HAIB:100067060; DKFZo004D0124 fibronectin 1 protein (FN1) gene, encodes complete protein.
AB384664 - Synthetic construct DNA, clone: pF1KB0006, Homo sapiens FN1 gene for fibronectin precursor, complete cds, without stop codon, in Flexi system.
AB385106 - Synthetic construct DNA, clone: pF1KB5488, Homo sapiens FN1 gene for fibronectin precursor, complete cds, without stop codon, in Flexi system.
MA440811 - JP 2018138019-A/12737: Polycomb-Associated Non-Coding RNAs.
BC005858 - Homo sapiens fibronectin 1, mRNA (cDNA clone IMAGE:3506187), partial cds.
BX641150 - Homo sapiens mRNA; cDNA DKFZp686H05109 (from clone DKFZp686H05109).
CR936623 - Homo sapiens mRNA; cDNA DKFZp686I1370 (from clone DKFZp686I1370).
CR749666 - Homo sapiens mRNA; cDNA DKFZp686O13149 (from clone DKFZp686O13149).
AK026737 - Homo sapiens cDNA: FLJ23084 fis, clone LNG06602, highly similar to HSFIB1 Human mRNA for fibronectin (FN precursor).
BC016875 - Homo sapiens fibronectin 1, mRNA (cDNA clone IMAGE:3886582), partial cds.
AF130095 - Homo sapiens clone FLC0562 PRO2841 mRNA, complete cds.
BX640638 - Homo sapiens mRNA; cDNA DKFZp686L11144 (from clone DKFZp686L11144).
BX640920 - Homo sapiens mRNA; cDNA DKFZp686O22169 (from clone DKFZp686O22169).
AK094153 - Homo sapiens cDNA FLJ36834 fis, clone ASTRO2010962, moderately similar to FIBRONECTIN PRECURSOR.
AB209287 - Homo sapiens mRNA for Fibronectin 1 variant protein.
LF318273 - JP 2014500723-A/125776: Polycomb-Associated Non-Coding RNAs.
LF318274 - JP 2014500723-A/125777: Polycomb-Associated Non-Coding RNAs.
AK300246 - Homo sapiens cDNA FLJ53292 complete cds, highly similar to Homo sapiens fibronectin 1 (FN1), transcript variant 5, mRNA.
LF318276 - JP 2014500723-A/125779: Polycomb-Associated Non-Coding RNAs.
AK300458 - Homo sapiens cDNA FLJ54550 complete cds, highly similar to Homo sapiens fibronectin 1 (FN1), transcript variant 6, mRNA.
LF318278 - JP 2014500723-A/125781: Polycomb-Associated Non-Coding RNAs.
AK297733 - Homo sapiens cDNA FLJ53365 complete cds, highly similar to Homo sapiens fibronectin 1 (FN1), transcript variant 4, mRNA.
JD393318 - Sequence 374342 from Patent EP1572962.
AK316350 - Homo sapiens cDNA, FLJ79249 complete cds, highly similar to Homo sapiens fibronectin 1 (FN1), transcript variant 4, mRNA.
JD023640 - Sequence 4664 from Patent EP1572962.
JD271962 - Sequence 252986 from Patent EP1572962.
AK300216 - Homo sapiens cDNA FLJ61165 complete cds, highly similar to Fibronectin precursor.
U42456 - Human fibronectin (FN1) mRNA, C-terminus, partial cds.
JD387875 - Sequence 368899 from Patent EP1572962.
JD019405 - Sequence 429 from Patent EP1572962.
LF318281 - JP 2014500723-A/125784: Polycomb-Associated Non-Coding RNAs.
JD288808 - Sequence 269832 from Patent EP1572962.
U42592 - Human fibronectin (FN1) mRNA, C-terminal domains, partial cds.
JD138121 - Sequence 119145 from Patent EP1572962.
JD391643 - Sequence 372667 from Patent EP1572962.
M10905 - Human cellular fibronectin mRNA.
BT006856 - Homo sapiens fibronectin 1 mRNA, complete cds.
LF318283 - JP 2014500723-A/125786: Polycomb-Associated Non-Coding RNAs.
LF318289 - JP 2014500723-A/125792: Polycomb-Associated Non-Coding RNAs.
AJ320525 - Homo sapiens partial mRNA for fibronectin (V+I-10)- splice variant (FN gene).
AJ320526 - Homo sapiens partial mRNA for fibronectin (V+III-15)- splice variant (FN gene).
AJ320527 - Homo sapiens partial mRNA for fibronectin III-15X splice variant (FN gene).
LF318291 - JP 2014500723-A/125794: Polycomb-Associated Non-Coding RNAs.
LF318296 - JP 2014500723-A/125799: Polycomb-Associated Non-Coding RNAs.
LF318298 - JP 2014500723-A/125801: Polycomb-Associated Non-Coding RNAs.
EF550130 - Homo sapiens fibronectin splice variant A (FN1) mRNA, partial cds, alternatively spliced.
EF550131 - Homo sapiens fibronectin splice variant B (FN1) mRNA, partial cds, alternatively spliced.
EF550132 - Homo sapiens fibronectin splice variant C (FN1) mRNA, partial cds, alternatively spliced.
EF550133 - Homo sapiens fibronectin splice variant D (FN1) mRNA, partial cds, alternatively spliced.
EF550134 - Homo sapiens fibronectin splice variant E (FN1) mRNA, partial cds, alternatively spliced.
EF550135 - Homo sapiens fibronectin splice variant F (FN1) mRNA, partial cds, alternatively spliced.
LF318301 - JP 2014500723-A/125804: Polycomb-Associated Non-Coding RNAs.
U41724 - Human fibronectin (FN1) mRNA, alternative splicing variant V0, partial cds.
U41850 - Human fibronectin (FN1) mRNA, alternative splicing variant V89, partial cds.
U42455 - Human fibronectin (FN1) mRNA, alternative splicing variant V89, partial cds.
JD031989 - Sequence 13013 from Patent EP1572962.
JD020713 - Sequence 1737 from Patent EP1572962.
U42593 - Human fibronectin (FN1) mRNA, splice variant, partial cds.
U42594 - Human fibronectin (FN1) mRNA, splice variant, partial cds.
LF318304 - JP 2014500723-A/125807: Polycomb-Associated Non-Coding RNAs.
JD023884 - Sequence 4908 from Patent EP1572962.
AH002698 - Homo sapiens fibronectin (FN1) mRNA, partial cds.
JD030684 - Sequence 11708 from Patent EP1572962.
U60067 - Human fibronectin mRNA, partial cds.
U60068 - Human fibronectin mRNA, alternatively spliced, partial cds.
LF318306 - JP 2014500723-A/125809: Polycomb-Associated Non-Coding RNAs.
M27589 - Human liver fibronectin mRNA, partial cds.
LF318308 - JP 2014500723-A/125811: Polycomb-Associated Non-Coding RNAs.
M27590 - Human liver fibronectin mRNA, partial cds.
LF318310 - JP 2014500723-A/125813: Polycomb-Associated Non-Coding RNAs.
LF318312 - JP 2014500723-A/125815: Polycomb-Associated Non-Coding RNAs.
LF318314 - JP 2014500723-A/125817: Polycomb-Associated Non-Coding RNAs.
LF318316 - JP 2014500723-A/125819: Polycomb-Associated Non-Coding RNAs.
LF318318 - JP 2014500723-A/125821: Polycomb-Associated Non-Coding RNAs.
LF318320 - JP 2014500723-A/125823: Polycomb-Associated Non-Coding RNAs.
U42458 - Human fibronectin (FN1) mRNA, splice variant not containing EIIIA domain, partial cds.
LF318321 - JP 2014500723-A/125824: Polycomb-Associated Non-Coding RNAs.
LF318324 - JP 2014500723-A/125827: Polycomb-Associated Non-Coding RNAs.
LF318326 - JP 2014500723-A/125829: Polycomb-Associated Non-Coding RNAs.
LF318329 - JP 2014500723-A/125832: Polycomb-Associated Non-Coding RNAs.
LF318331 - JP 2014500723-A/125834: Polycomb-Associated Non-Coding RNAs.
JD026865 - Sequence 7889 from Patent EP1572962.
LF318333 - JP 2014500723-A/125836: Polycomb-Associated Non-Coding RNAs.
LF318335 - JP 2014500723-A/125838: Polycomb-Associated Non-Coding RNAs.
LF318336 - JP 2014500723-A/125839: Polycomb-Associated Non-Coding RNAs.
LF318338 - JP 2014500723-A/125841: Polycomb-Associated Non-Coding RNAs.
LF318341 - JP 2014500723-A/125844: Polycomb-Associated Non-Coding RNAs.
LF318343 - JP 2014500723-A/125846: Polycomb-Associated Non-Coding RNAs.
U42457 - Human fibronectin (FN1) mRNA, splice variant not containing EIIIB domain, partial cds.
LF318345 - JP 2014500723-A/125848: Polycomb-Associated Non-Coding RNAs.
LF318347 - JP 2014500723-A/125850: Polycomb-Associated Non-Coding RNAs.
LF318349 - JP 2014500723-A/125852: Polycomb-Associated Non-Coding RNAs.
LF318350 - JP 2014500723-A/125853: Polycomb-Associated Non-Coding RNAs.
LF318354 - JP 2014500723-A/125857: Polycomb-Associated Non-Coding RNAs.
LF318355 - JP 2014500723-A/125858: Polycomb-Associated Non-Coding RNAs.
LF318357 - JP 2014500723-A/125860: Polycomb-Associated Non-Coding RNAs.
LF318359 - JP 2014500723-A/125862: Polycomb-Associated Non-Coding RNAs.
LF318365 - JP 2014500723-A/125868: Polycomb-Associated Non-Coding RNAs.
LF318369 - JP 2014500723-A/125872: Polycomb-Associated Non-Coding RNAs.
LF318370 - JP 2014500723-A/125873: Polycomb-Associated Non-Coding RNAs.
LF318371 - JP 2014500723-A/125874: Polycomb-Associated Non-Coding RNAs.
MA553850 - JP 2018138019-A/125776: Polycomb-Associated Non-Coding RNAs.
MA553851 - JP 2018138019-A/125777: Polycomb-Associated Non-Coding RNAs.
MA553853 - JP 2018138019-A/125779: Polycomb-Associated Non-Coding RNAs.
MA553855 - JP 2018138019-A/125781: Polycomb-Associated Non-Coding RNAs.
MA553858 - JP 2018138019-A/125784: Polycomb-Associated Non-Coding RNAs.
MA553860 - JP 2018138019-A/125786: Polycomb-Associated Non-Coding RNAs.
MA553866 - JP 2018138019-A/125792: Polycomb-Associated Non-Coding RNAs.
MA553868 - JP 2018138019-A/125794: Polycomb-Associated Non-Coding RNAs.
MA553873 - JP 2018138019-A/125799: Polycomb-Associated Non-Coding RNAs.
MA553875 - JP 2018138019-A/125801: Polycomb-Associated Non-Coding RNAs.
MA553878 - JP 2018138019-A/125804: Polycomb-Associated Non-Coding RNAs.
MA553881 - JP 2018138019-A/125807: Polycomb-Associated Non-Coding RNAs.
MA553883 - JP 2018138019-A/125809: Polycomb-Associated Non-Coding RNAs.
MA553885 - JP 2018138019-A/125811: Polycomb-Associated Non-Coding RNAs.
MA553887 - JP 2018138019-A/125813: Polycomb-Associated Non-Coding RNAs.
MA553889 - JP 2018138019-A/125815: Polycomb-Associated Non-Coding RNAs.
MA553891 - JP 2018138019-A/125817: Polycomb-Associated Non-Coding RNAs.
MA553893 - JP 2018138019-A/125819: Polycomb-Associated Non-Coding RNAs.
MA553895 - JP 2018138019-A/125821: Polycomb-Associated Non-Coding RNAs.
MA553897 - JP 2018138019-A/125823: Polycomb-Associated Non-Coding RNAs.
MA553898 - JP 2018138019-A/125824: Polycomb-Associated Non-Coding RNAs.
MA553901 - JP 2018138019-A/125827: Polycomb-Associated Non-Coding RNAs.
MA553903 - JP 2018138019-A/125829: Polycomb-Associated Non-Coding RNAs.
MA553906 - JP 2018138019-A/125832: Polycomb-Associated Non-Coding RNAs.
MA553908 - JP 2018138019-A/125834: Polycomb-Associated Non-Coding RNAs.
MA553910 - JP 2018138019-A/125836: Polycomb-Associated Non-Coding RNAs.
MA553912 - JP 2018138019-A/125838: Polycomb-Associated Non-Coding RNAs.
MA553913 - JP 2018138019-A/125839: Polycomb-Associated Non-Coding RNAs.
MA553915 - JP 2018138019-A/125841: Polycomb-Associated Non-Coding RNAs.
MA553918 - JP 2018138019-A/125844: Polycomb-Associated Non-Coding RNAs.
MA553920 - JP 2018138019-A/125846: Polycomb-Associated Non-Coding RNAs.
MA553922 - JP 2018138019-A/125848: Polycomb-Associated Non-Coding RNAs.
MA553924 - JP 2018138019-A/125850: Polycomb-Associated Non-Coding RNAs.
MA553926 - JP 2018138019-A/125852: Polycomb-Associated Non-Coding RNAs.
MA553927 - JP 2018138019-A/125853: Polycomb-Associated Non-Coding RNAs.
MA553931 - JP 2018138019-A/125857: Polycomb-Associated Non-Coding RNAs.
MA553932 - JP 2018138019-A/125858: Polycomb-Associated Non-Coding RNAs.
MA553934 - JP 2018138019-A/125860: Polycomb-Associated Non-Coding RNAs.
MA553936 - JP 2018138019-A/125862: Polycomb-Associated Non-Coding RNAs.
MA553942 - JP 2018138019-A/125868: Polycomb-Associated Non-Coding RNAs.
MA553946 - JP 2018138019-A/125872: Polycomb-Associated Non-Coding RNAs.
MA553947 - JP 2018138019-A/125873: Polycomb-Associated Non-Coding RNAs.
MA553948 - JP 2018138019-A/125874: Polycomb-Associated Non-Coding RNAs.
LF318373 - JP 2014500723-A/125876: Polycomb-Associated Non-Coding RNAs.
LF318376 - JP 2014500723-A/125879: Polycomb-Associated Non-Coding RNAs.
LF318377 - JP 2014500723-A/125880: Polycomb-Associated Non-Coding RNAs.
LF318378 - JP 2014500723-A/125881: Polycomb-Associated Non-Coding RNAs.
LF318380 - JP 2014500723-A/125883: Polycomb-Associated Non-Coding RNAs.
LF318382 - JP 2014500723-A/125885: Polycomb-Associated Non-Coding RNAs.
LF318383 - JP 2014500723-A/125886: Polycomb-Associated Non-Coding RNAs.
LF318385 - JP 2014500723-A/125888: Polycomb-Associated Non-Coding RNAs.
LF318388 - JP 2014500723-A/125891: Polycomb-Associated Non-Coding RNAs.
LF318391 - JP 2014500723-A/125894: Polycomb-Associated Non-Coding RNAs.
LF318393 - JP 2014500723-A/125896: Polycomb-Associated Non-Coding RNAs.
AJ849445 - Homo sapiens FN1 precursor mRNA for migration stimulating factor (FN1 gene).
BX538045 - Homo sapiens mRNA; cDNA DKFZp686B18150 (from clone DKFZp686B18150).
AJ276395 - Homo sapiens mRNA for MSF-FN70 (FN gene).
AJ535086 - Homo sapiens mRNA for migration stimulation factor FN70+ (FN gene).
LF318397 - JP 2014500723-A/125900: Polycomb-Associated Non-Coding RNAs.
LF318400 - JP 2014500723-A/125903: Polycomb-Associated Non-Coding RNAs.
LF318402 - JP 2014500723-A/125905: Polycomb-Associated Non-Coding RNAs.
LF318404 - JP 2014500723-A/125907: Polycomb-Associated Non-Coding RNAs.
AF312399 - Homo sapiens fibronectin mRNA, partial cds.
LF318406 - JP 2014500723-A/125909: Polycomb-Associated Non-Coding RNAs.
LF318408 - JP 2014500723-A/125911: Polycomb-Associated Non-Coding RNAs.
U42404 - Human fibronectin (FN1) mRNA, N-terminal domains, partial cds.
LF318410 - JP 2014500723-A/125913: Polycomb-Associated Non-Coding RNAs.
LF318412 - JP 2014500723-A/125915: Polycomb-Associated Non-Coding RNAs.
LF318415 - JP 2014500723-A/125918: Polycomb-Associated Non-Coding RNAs.
LF318416 - JP 2014500723-A/125919: Polycomb-Associated Non-Coding RNAs.
LF318417 - JP 2014500723-A/125920: Polycomb-Associated Non-Coding RNAs.
LF318418 - JP 2014500723-A/125921: Polycomb-Associated Non-Coding RNAs.
LF318422 - JP 2014500723-A/125925: Polycomb-Associated Non-Coding RNAs.
LF318424 - JP 2014500723-A/125927: Polycomb-Associated Non-Coding RNAs.
LF318431 - JP 2014500723-A/125934: Polycomb-Associated Non-Coding RNAs.
LF318433 - JP 2014500723-A/125936: Polycomb-Associated Non-Coding RNAs.
LF318436 - JP 2014500723-A/125939: Polycomb-Associated Non-Coding RNAs.
LF318438 - JP 2014500723-A/125941: Polycomb-Associated Non-Coding RNAs.
LF318443 - JP 2014500723-A/125946: Polycomb-Associated Non-Coding RNAs.
LF318445 - JP 2014500723-A/125948: Polycomb-Associated Non-Coding RNAs.
LF318447 - JP 2014500723-A/125950: Polycomb-Associated Non-Coding RNAs.
JD360719 - Sequence 341743 from Patent EP1572962.
JD556793 - Sequence 537817 from Patent EP1572962.
JD121823 - Sequence 102847 from Patent EP1572962.
JD143194 - Sequence 124218 from Patent EP1572962.
JD393977 - Sequence 375001 from Patent EP1572962.
JD226561 - Sequence 207585 from Patent EP1572962.
JD227127 - Sequence 208151 from Patent EP1572962.
JD483837 - Sequence 464861 from Patent EP1572962.
JD484054 - Sequence 465078 from Patent EP1572962.
JD155637 - Sequence 136661 from Patent EP1572962.
LF318450 - JP 2014500723-A/125953: Polycomb-Associated Non-Coding RNAs.
MA553950 - JP 2018138019-A/125876: Polycomb-Associated Non-Coding RNAs.
MA553953 - JP 2018138019-A/125879: Polycomb-Associated Non-Coding RNAs.
MA553954 - JP 2018138019-A/125880: Polycomb-Associated Non-Coding RNAs.
MA553955 - JP 2018138019-A/125881: Polycomb-Associated Non-Coding RNAs.
MA553957 - JP 2018138019-A/125883: Polycomb-Associated Non-Coding RNAs.
MA553959 - JP 2018138019-A/125885: Polycomb-Associated Non-Coding RNAs.
MA553960 - JP 2018138019-A/125886: Polycomb-Associated Non-Coding RNAs.
MA553962 - JP 2018138019-A/125888: Polycomb-Associated Non-Coding RNAs.
MA553965 - JP 2018138019-A/125891: Polycomb-Associated Non-Coding RNAs.
MA553968 - JP 2018138019-A/125894: Polycomb-Associated Non-Coding RNAs.
MA553970 - JP 2018138019-A/125896: Polycomb-Associated Non-Coding RNAs.
MA553974 - JP 2018138019-A/125900: Polycomb-Associated Non-Coding RNAs.
MA553977 - JP 2018138019-A/125903: Polycomb-Associated Non-Coding RNAs.
MA553979 - JP 2018138019-A/125905: Polycomb-Associated Non-Coding RNAs.
MA553981 - JP 2018138019-A/125907: Polycomb-Associated Non-Coding RNAs.
MA553983 - JP 2018138019-A/125909: Polycomb-Associated Non-Coding RNAs.
MA553985 - JP 2018138019-A/125911: Polycomb-Associated Non-Coding RNAs.
MA553987 - JP 2018138019-A/125913: Polycomb-Associated Non-Coding RNAs.
MA553989 - JP 2018138019-A/125915: Polycomb-Associated Non-Coding RNAs.
MA553992 - JP 2018138019-A/125918: Polycomb-Associated Non-Coding RNAs.
MA553993 - JP 2018138019-A/125919: Polycomb-Associated Non-Coding RNAs.
MA553994 - JP 2018138019-A/125920: Polycomb-Associated Non-Coding RNAs.
MA553995 - JP 2018138019-A/125921: Polycomb-Associated Non-Coding RNAs.
MA553999 - JP 2018138019-A/125925: Polycomb-Associated Non-Coding RNAs.
MA554001 - JP 2018138019-A/125927: Polycomb-Associated Non-Coding RNAs.
MA554008 - JP 2018138019-A/125934: Polycomb-Associated Non-Coding RNAs.
MA554010 - JP 2018138019-A/125936: Polycomb-Associated Non-Coding RNAs.
MA554013 - JP 2018138019-A/125939: Polycomb-Associated Non-Coding RNAs.
MA554015 - JP 2018138019-A/125941: Polycomb-Associated Non-Coding RNAs.
MA554020 - JP 2018138019-A/125946: Polycomb-Associated Non-Coding RNAs.
MA554022 - JP 2018138019-A/125948: Polycomb-Associated Non-Coding RNAs.
MA554024 - JP 2018138019-A/125950: Polycomb-Associated Non-Coding RNAs.
MA554027 - JP 2018138019-A/125953: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein P02751 (Reactome details) participates in the following event(s):

R-HSA-349593 Interaction of integrin alphaIIbbeta3 with Fibronectin
R-HSA-2327733 FN1 binds Collagen types I-V, VII
R-HSA-2545196 FN1 dimerizes
R-HSA-202723 Integrin alpha5beta1 binds FN1 dimer
R-HSA-354149 Interaction of integrin alphaIIb beta3 with Fibrinogen
R-HSA-481007 Exocytosis of platelet alpha granule contents
R-HSA-377641 Clustering of Integrin alphaIIb beta3 complexes
R-HSA-377643 Dephosphorylation of inactive SRC by PTPB1
R-HSA-377644 Release of CSK from SRC
R-HSA-377640 Autophosphorylation of SRC
R-HSA-354066 Translocation of FADK1 to Focal complexes
R-HSA-429415 SYK binds to integrin alphaIIb beta3
R-HSA-8952289 FAM20C phosphorylates FAM20C substrates
R-HSA-354087 Recruitment of GRB2 to p-FADK1
R-HSA-372705 Recruitment of p130Cas to FADK1
R-HSA-354124 Phosphorylation of pFADK1 by SRC
R-HSA-354073 Autophosphorylation of FADK1 at Y397
R-HSA-429441 SYK activation by SRC
R-HSA-354165 Interaction of SOS with GRB2 bound to FADK1
R-HSA-372697 Crk binding to p130cas
R-HSA-372693 Phosphorylation of p130Cas by SRC-FADK1 complex
R-HSA-5672972 MAP2Ks and MAPKs bind to the activated RAF complex
R-HSA-6802912 High kinase activity BRAF mutants bind MAP2Ks and MAPKs
R-HSA-6802914 RAS:GTP:moderate kinase activity p-RAF complexes bind MAP2Ks and MAPKs
R-HSA-6802925 Mutant RAS:p-RAF complexes bind MAP2Ks and MAPKs
R-HSA-6802934 p-BRAF and RAF fusion dimers bind MAP2Ks and MAPKs
R-HSA-6802942 RAS:GTP:p-RAF complexes paradoxically bind MAP2Ks and MAPKs
R-HSA-5672980 Dissociation of RAS:RAF complex
R-HSA-6802932 Dissociation of BRAF/RAF fusion complex
R-HSA-6803227 Dissociation of high activity BRAF complexes
R-HSA-6803230 Dissociation of moderate activity BRAF complexes
R-HSA-6803233 Dissociation of oncogenic RAS:RAF complex
R-HSA-6803234 Dissociation of paradoxically activated RAS:BRAF complexes
R-HSA-5672978 RAF phosphorylates MAP2K dimer
R-HSA-5672973 MAP2Ks phosphorylate MAPKs
R-HSA-6802918 Activated MAP2Ks phosphorylate MAPKs downstream of inactive BRAF mutants
R-HSA-6802943 RAS:GTP:inactive p-RAF complexes phosphorylate MAP2Ks
R-HSA-6802919 RAS:GTP:moderate kinase activity p-RAF complexes phosphorylate MAP2Ks
R-HSA-6802921 Activated MAP2Ks phosphorylate MAPKs downstream of moderate kinase activity BRAF mutants
R-HSA-6802911 High kinase activity BRAF complexes phosphorylate MAP2Ks
R-HSA-6802910 Activated MAP2Ks phosphorylate MAPKs downstream of high kinase activity BRAF mutants
R-HSA-6802926 Mutant RAS:p-RAF complexes phosphorylate MAP2Ks
R-HSA-6802922 Activated MAP2Ks phosphorylate MAPKs downstream of oncogenic RAS
R-HSA-6802933 p-BRAF and RAF fusion dimers phosphorylate MAP2Ks
R-HSA-6802935 MAPKs are phosphorylated downstream of BRAF and RAF fusion dimers
R-HSA-216083 Integrin cell surface interactions
R-HSA-1474244 Extracellular matrix organization
R-HSA-1566977 Fibronectin matrix formation
R-HSA-202733 Cell surface interactions at the vascular wall
R-HSA-354192 Integrin alphaIIb beta3 signaling
R-HSA-114608 Platelet degranulation
R-HSA-6785807 Interleukin-4 and 13 signaling
R-HSA-109582 Hemostasis
R-HSA-76009 Platelet Aggregation (Plug Formation)
R-HSA-9006921 Integrin signaling
R-HSA-76005 Response to elevated platelet cytosolic Ca2+
R-HSA-449147 Signaling by Interleukins
R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-HSA-8957275 Post-translational protein phosphorylation
R-HSA-354194 GRB2:SOS provides linkage to MAPK signaling for Integrins
R-HSA-372708 p130Cas linkage to MAPK signaling for integrins
R-HSA-76002 Platelet activation, signaling and aggregation
R-HSA-162582 Signal Transduction
R-HSA-1280215 Cytokine Signaling in Immune system
R-HSA-392499 Metabolism of proteins
R-HSA-597592 Post-translational protein modification
R-HSA-168256 Immune System
R-HSA-5674135 MAP2K and MAPK activation
R-HSA-6802948 Signaling by high-kinase activity BRAF mutants
R-HSA-6802946 Signaling by moderate kinase activity BRAF mutants
R-HSA-6802949 Signaling by RAS mutants
R-HSA-6802952 Signaling by BRAF and RAF fusions
R-HSA-6802955 Paradoxical activation of RAF signaling by kinase inactive BRAF
R-HSA-5673001 RAF/MAP kinase cascade
R-HSA-6802957 Oncogenic MAPK signaling
R-HSA-5684996 MAPK1/MAPK3 signaling
R-HSA-5663202 Diseases of signal transduction
R-HSA-5683057 MAPK family signaling cascades
R-HSA-1643685 Disease

-  Other Names for This Gene
  Alternate Gene Symbols: B7ZLF0, E9PE77, E9PG29, ENST00000354785.1, ENST00000354785.10, ENST00000354785.2, ENST00000354785.3, ENST00000354785.4, ENST00000354785.5, ENST00000354785.6, ENST00000354785.7, ENST00000354785.8, ENST00000354785.9, FINC_HUMAN, FN, FN1 , NM_212482, O95609, O95610, P02751, Q14312, Q14325, Q14326, Q17RV7, Q53S27, Q564H7, Q585T2, Q59EH1, Q60FE4, Q68DP8, Q68DP9, Q68DT4, Q6LDP6, Q6MZS0, Q6MZU5, Q6N025, Q6N0A6, Q7Z391, Q86T27, Q8IVI8, Q96KP7, Q96KP8, Q96KP9, Q9H1B8, Q9HAP3, Q9UMK2, uc317yuj.1, uc317yuj.2
UCSC ID: ENST00000354785.11_13
RefSeq Accession: NM_212482.4
Protein: P02751 (aka FINC_HUMAN)

-  GeneReviews for This Gene
  GeneReviews article(s) related to gene FN1:
smdcf (Spondylometaphyseal Dysplasia, Corner Fracture Type)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.