ID:FOLR1_HUMAN DESCRIPTION: RecName: Full=Folate receptor alpha; Short=FR-alpha; AltName: Full=Adult folate-binding protein; Short=FBP; AltName: Full=Folate receptor 1; AltName: Full=Folate receptor, adult; AltName: Full=KB cells FBP; AltName: Full=Ovarian tumor-associated antigen MOv18; Flags: Precursor; FUNCTION: Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate to the interior of cells. SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor, GPI-anchor. Secreted (Probable). TISSUE SPECIFICITY: Exclusively expressed in tissues of epithelial origin. Expression is increased in malignant tissues. Expressed in kidney, lung and cerebellum. PTM: Eight disulfide bonds are present (Probable). PTM: The secreted form is derived from the membrane-bound form either by cleavage of the GPI anchor, or/and by proteolysis catalyzed by a metalloprotease. DISEASE: Defects in FOLR1 are the cause of neurodegeneration due to cerebral folate transport deficiency (NCFTD) [MIM:613068]. NCFTD is an autosomal recessive disorder resulting from brain- specific folate deficiency early in life. Onset is apparent in late infancy with severe developmental regression, movement disturbances, epilepsy, and leukodystrophy. Note=Recognition and diagnosis of this disorder is critical because folinic acid therapy can reverse the clinical symptoms and improve brain abnormalities and function. SIMILARITY: Belongs to the folate receptor family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P15328
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
J05013 - Human folate-binding protein (FBP) mRNA, complete cds. BC002947 - Homo sapiens folate receptor 1 (adult), mRNA (cDNA clone MGC:10473 IMAGE:3956659), complete cds. AK223527 - Homo sapiens mRNA for folate receptor 1 precursor variant, clone: FCC124E04. M28099 - Human folate-binding protein (FBP) mRNA, complete cds. X62753 - H.sapiens mRNA for adult folate binding protein. U78793 - Human folate receptor alpha (hFR) mRNA, partial cds. JD556119 - Sequence 537143 from Patent EP1572962. U78794 - Human folate receptor alpha (hFR) mRNA, alternatively spliced, partial cds. AH004606 - Homo sapiens folate receptor alpha isoform mRNAs, partial cds. AB590148 - Synthetic construct DNA, clone: pFN21AE1415, Homo sapiens FOLR1 gene for folate receptor 1, without stop codon, in Flexi system. DQ892744 - Synthetic construct clone IMAGE:100005374; FLH189297.01X; RZPDo839D0874D folate receptor 1 (adult) (FOLR1) gene, encodes complete protein. DQ895990 - Synthetic construct Homo sapiens clone IMAGE:100010450; FLH189293.01L; RZPDo839D0864D folate receptor 1 (adult) (FOLR1) gene, encodes complete protein. CR542019 - Homo sapiens full open reading frame cDNA clone RZPDo834H0535D for gene FOLR1, folate receptor 1 (adult); complete cds, without stopcodon. BT007158 - Homo sapiens folate receptor 1 (adult) mRNA, complete cds. M25317 - Human folate binding protein (FBP) mRNA, 3' end. M35069 - Human folate binding protein mRNA, partial cds. KU257686 - Homo sapiens folate receptor mRNA, partial cds. AF000381 - Homo sapiens folate binding protein mRNA, partial cds. JD354723 - Sequence 335747 from Patent EP1572962. JD424326 - Sequence 405350 from Patent EP1572962. JD200424 - Sequence 181448 from Patent EP1572962. JD399655 - Sequence 380679 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein P15328 (Reactome details) participates in the following event(s):
R-HSA-5694410 TMED2:TMED10 tetramer binds GPI anchored proteins R-HSA-5694522 Inner coat assembly and cargo binding R-HSA-5694527 Loss of SAR1B GTPase R-HSA-5694446 BET1:GOSR2:STX5 bind v-SNARES on tethered vesicle R-HSA-6807875 ARFGAP, cargo, v-SNAREs and p24 proteins bind nascent COPI complex R-HSA-5694417 SEC16 complex binds SAR1B:GTP:SEC23:SEC24 R-HSA-5694441 CSNK1D phosphorylates SEC23 R-HSA-5694439 COPII coat binds TRAPPCII and RAB1:GDP R-HSA-203973 Vesicle budding R-HSA-6807877 ARFGAPs stimulate ARF GTPase activity R-HSA-6809003 ERGIC-to-Golgi vesicles bind dynein:dynactin R-HSA-204008 SEC31:SEC13 and v-SNARE recruitment R-HSA-5694418 RAB1:GTP binds USO1 and GORASP1:GOLGA2 R-HSA-5694409 Nucleotide exchange on RAB1 R-HSA-6809011 cis-Golgi t-SNAREs bind YKT6 on tethered vesicle R-HSA-6809006 Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex R-HSA-5694530 Cargo concentration in the ER R-HSA-199977 ER to Golgi Anterograde Transport R-HSA-204005 COPII-mediated vesicle transport R-HSA-199991 Membrane Trafficking R-HSA-948021 Transport to the Golgi and subsequent modification R-HSA-6807878 COPI-mediated anterograde transport R-HSA-5653656 Vesicle-mediated transport R-HSA-446203 Asparagine N-linked glycosylation R-HSA-597592 Post-translational protein modification R-HSA-392499 Metabolism of proteins