Human Gene FOS (ENST00000303562.9_4) from GENCODE V47lift37
  Description: Fos proto-oncogene, AP-1 transcription factor subunit (from RefSeq NM_005252.4)
Gencode Transcript: ENST00000303562.9_4
Gencode Gene: ENSG00000170345.11_9
Transcript (Including UTRs)
   Position: hg19 chr14:75,745,531-75,748,933 Size: 3,403 Total Exon Count: 4 Strand: +
Coding Region
   Position: hg19 chr14:75,745,686-75,748,127 Size: 2,442 Coding Exon Count: 4 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr14:75,745,531-75,748,933)mRNA (may differ from genome)Protein (380 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
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HGNCMalacardsMGIOMIMPubMedUniProtKB
WikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: Q6FG41_HUMAN
DESCRIPTION: SubName: Full=FOS protein; SubName: Full=V-fos FBJ murine osteosarcoma viral oncogene homolog, isoform CRA_a; SubName: Full=cDNA FLJ76842, highly similar to Homo sapiens v-fos FBJ murine osteosarcoma viral oncogene homolog (FOS), mRNA;
SIMILARITY: Contains 1 bZIP (basic-leucine zipper) domain.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: FOS
Diseases sorted by gene-association score: acute pericementitis (15), pertussis (13), fibrodysplasia ossificans progressiva (13), cerebral hypoxia (12), myositis ossificans (10), fumarate hydratase deficiency (9), leber congenital amaurosis 6 (8), audiogenic seizures (8), status epilepticus (7), withdrawal disorder (7), coffin-lowry syndrome (7), ocular hypertension (6), malignant fibrous histiocytoma of bone (6), breast adenocarcinoma (6), marcus gunn phenomenon (6), motion sickness (6), testicular leukemia (5), glycogen storage disease vi (5), morphine dependence (5), juxtacortical osteosarcoma (5), periosteal osteogenic sarcoma (5), malignant histiocytosis (5), photokeratitis (5), lymph node cancer (5), peripheral osteosarcoma (4), occlusion precerebral artery (4), space motion sickness (4), amnestic disorder (4), patellofemoral pain syndrome (4), disuse amblyopia (4), osteoporosis (4), endometrial cancer (4), amyotrophic lateral sclerosis 9 (4), drug-induced mental disorder (3), drug psychosis (3), transient global amnesia (3), amyotrophic lateral sclerosis 7 (3), colorectal cancer (3), rheumatoid arthritis (3), breast cancer (3), osteosarcoma, somatic (2), attention deficit-hyperactivity disorder (2), pheochromocytoma (2), pain agnosia (1), agnosia (1), disease of mental health (1), thyroid cancer, nonmedullary, 2 (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 814.02 RPKM in Fallopian Tube
Total median expression: 4887.05 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -47.80155-0.308 Picture PostScript Text
3' UTR -220.30806-0.273 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR004827 - bZIP
IPR000837 - Leuzip_Fos

Pfam Domains:
PF00170 - bZIP transcription factor
PF03131 - bZIP Maf transcription factor
PF07716 - Basic region leucine zipper

SCOP Domains:
47454 - A DNA-binding domain in eukaryotic transcription factors
57959 - Leucine zipper domain

ModBase Predicted Comparative 3D Structure on Q6FG41
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details Gene Details  
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003690 double-stranded DNA binding
GO:0003700 transcription factor activity, sequence-specific DNA binding
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0043565 sequence-specific DNA binding
GO:0046982 protein heterodimerization activity

Biological Process:
GO:0001661 conditioned taste aversion
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006366 transcription from RNA polymerase II promoter
GO:0007399 nervous system development
GO:0007565 female pregnancy
GO:0007568 aging
GO:0009409 response to cold
GO:0009416 response to light stimulus
GO:0009612 response to mechanical stimulus
GO:0009629 response to gravity
GO:0009636 response to toxic substance
GO:0014070 response to organic cyclic compound
GO:0030431 sleep
GO:0031668 cellular response to extracellular stimulus
GO:0032496 response to lipopolysaccharide
GO:0032570 response to progesterone
GO:0032870 cellular response to hormone stimulus
GO:0034097 response to cytokine
GO:0035902 response to immobilization stress
GO:0035914 skeletal muscle cell differentiation
GO:0035994 response to muscle stretch
GO:0042493 response to drug
GO:0045672 positive regulation of osteoclast differentiation
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0051412 response to corticosterone
GO:0051591 response to cAMP
GO:0071277 cellular response to calcium ion
GO:1901216 positive regulation of neuron death
GO:1902895 positive regulation of pri-miRNA transcription from RNA polymerase II promoter

Cellular Component:
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005667 transcription factor complex
GO:0016020 membrane
GO:0043005 neuron projection


-  Descriptions from all associated GenBank mRNAs
  KP790138 - Homo sapiens FOS/VIM fusion protein (FOS/VIM) mRNA, partial cds.
LF212504 - JP 2014500723-A/20007: Polycomb-Associated Non-Coding RNAs.
LF209606 - JP 2014500723-A/17109: Polycomb-Associated Non-Coding RNAs.
AK291326 - Homo sapiens cDNA FLJ76842 complete cds, highly similar to Homo sapiens v-fos FBJ murine osteosarcoma viral oncogene homolog (FOS), mRNA.
AK298659 - Homo sapiens cDNA FLJ55132 complete cds, highly similar to Proto-oncogene protein c-fos.
AK097379 - Homo sapiens cDNA FLJ40060 fis, clone TCOLN2000236, highly similar to Proto-oncogene protein c-fos.
BX647104 - Homo sapiens mRNA; cDNA DKFZp686J04124 (from clone DKFZp686J04124).
LF213788 - JP 2014500723-A/21291: Polycomb-Associated Non-Coding RNAs.
BC004490 - Homo sapiens v-fos FBJ murine osteosarcoma viral oncogene homolog, mRNA (cDNA clone MGC:11074 IMAGE:3688670), complete cds.
AH003773 - Homo sapiens FOS (c-fos) mRNA, complete cds.
DQ893444 - Synthetic construct clone IMAGE:100006074; FLH199535.01X; RZPDo839H0882D v-fos FBJ murine osteosarcoma viral oncogene homolog (FOS) gene, encodes complete protein.
DQ896750 - Synthetic construct Homo sapiens clone IMAGE:100011210; FLH199442.01L; RZPDo839H0881D v-fos FBJ murine osteosarcoma viral oncogene homolog (FOS) gene, encodes complete protein.
CU678740 - Synthetic construct Homo sapiens gateway clone IMAGE:100019160 5' read FOS mRNA.
AB385594 - Synthetic construct DNA, clone: pF1KB9574, Homo sapiens FOS gene for proto-oncogene protein c-fos, complete cds, without stop codon, in Flexi system.
CR541785 - Homo sapiens full open reading frame cDNA clone RZPDo834H0730D for gene FOS, v-fos FBJ murine osteosarcoma viral oncogene homolog; complete cds, without stopcodon.
CR542267 - Homo sapiens full open reading frame cDNA clone RZPDo834H0326D for gene FOS, v-fos FBJ murine osteosarcoma viral oncogene homolog; complete cds, incl. stopcodon.
KJ896826 - Synthetic construct Homo sapiens clone ccsbBroadEn_06220 FOS gene, encodes complete protein.
AK290907 - Homo sapiens cDNA FLJ77786 complete cds.
LF330109 - JP 2014500723-A/137612: Polycomb-Associated Non-Coding RNAs.
KP790139 - Homo sapiens FOS/RP11-326N17.1 fusion protein (FOS/RP11-326N17.1) mRNA, partial cds.
KP790137 - Homo sapiens FOS/MBNL1 fusion protein (FOS/MBNL1) mRNA, partial cds.
LF330111 - JP 2014500723-A/137614: Polycomb-Associated Non-Coding RNAs.
JD484093 - Sequence 465117 from Patent EP1572962.
JD173178 - Sequence 154202 from Patent EP1572962.
JD280612 - Sequence 261636 from Patent EP1572962.
JD188159 - Sequence 169183 from Patent EP1572962.
JD433247 - Sequence 414271 from Patent EP1572962.
JD349932 - Sequence 330956 from Patent EP1572962.
BD269368 - Gene showing enhanced expression in association with aging of cells and final differentiation of cells and utilization thereof.
JD494766 - Sequence 475790 from Patent EP1572962.
LF330112 - JP 2014500723-A/137615: Polycomb-Associated Non-Coding RNAs.
MA565686 - JP 2018138019-A/137612: Polycomb-Associated Non-Coding RNAs.
MA565688 - JP 2018138019-A/137614: Polycomb-Associated Non-Coding RNAs.
MA565689 - JP 2018138019-A/137615: Polycomb-Associated Non-Coding RNAs.
MA448081 - JP 2018138019-A/20007: Polycomb-Associated Non-Coding RNAs.
MA445183 - JP 2018138019-A/17109: Polycomb-Associated Non-Coding RNAs.
MA449365 - JP 2018138019-A/21291: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000303562.1, ENST00000303562.2, ENST00000303562.3, ENST00000303562.4, ENST00000303562.5, ENST00000303562.6, ENST00000303562.7, ENST00000303562.8, FOS , hCG_22355 , NM_005252, Q6FG41, Q6FG41_HUMAN, uc317ngi.1, uc317ngi.2
UCSC ID: ENST00000303562.9_4
RefSeq Accession: NM_005252.4
Protein: Q6FG41

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.