ID:FOXK1_HUMAN DESCRIPTION: RecName: Full=Forkhead box protein K1; AltName: Full=Myocyte nuclear factor; Short=MNF; FUNCTION: Transcriptional regulator that binds to the upstream enhancer region (CCAC box) of myoglobin gene. Has a role in myogenic differentiation and in remodeling processes of adult muscles that occur in response to physiological stimuli (By similarity). SUBUNIT: Interacts with SIN3B to form a complex which represses transcription (By similarity). INTERACTION: P14316:IRF2; NbExp=2; IntAct=EBI-2509974, EBI-2866589; SUBCELLULAR LOCATION: Nucleus (Probable). TISSUE SPECIFICITY: Expressed both developing and adult tissues. In adults, significant expression is seen in tumors of the brain, colon and lymph node. SIMILARITY: Contains 1 FHA domain. SIMILARITY: Contains 1 fork-head DNA-binding domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P85037
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0003677 DNA binding GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0005515 protein binding GO:0043565 sequence-specific DNA binding
Biological Process: GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006357 regulation of transcription from RNA polymerase II promoter GO:0007275 multicellular organism development GO:0007517 muscle organ development GO:0009653 anatomical structure morphogenesis GO:0016579 protein deubiquitination GO:0030154 cell differentiation GO:0045892 negative regulation of transcription, DNA-templated GO:0045893 positive regulation of transcription, DNA-templated
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
