Human Gene FOXM1 (ENST00000359843.8_12) from GENCODE V47lift37
  Description: forkhead box M1, transcript variant 2 (from RefSeq NM_021953.4)
Gencode Transcript: ENST00000359843.8_12
Gencode Gene: ENSG00000111206.13_14
Transcript (Including UTRs)
   Position: hg19 chr12:2,966,846-2,986,340 Size: 19,495 Total Exon Count: 9 Strand: -
Coding Region
   Position: hg19 chr12:2,967,804-2,983,644 Size: 15,841 Coding Exon Count: 8 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr12:2,966,846-2,986,340)mRNA (may differ from genome)Protein (763 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedUniProtKB
WikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: Q53Y49_HUMAN
DESCRIPTION: SubName: Full=Forkhead box M1; SubName: Full=Forkhead box M1, isoform CRA_a; SubName: Full=PIG29;
SIMILARITY: Contains 1 fork-head DNA-binding domain.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: FOXM1
Diseases sorted by gene-association score: meckel's diverticulum (13), balanoposthitis (7), cardiomyopathy, hypertrophic, 2 (5), cervix carcinoma (5), maturity-onset diabetes of the young (3), hepatocellular carcinoma (2), lung cancer susceptibility 3 (1), diabetes mellitus, insulin-dependent (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene
  • D013749 Tetrachlorodibenzodioxin
  • D001564 Benzo(a)pyrene
  • D002945 Cisplatin
  • C028474 1,4-bis(2-(3,5-dichloropyridyloxy))benzene
  • C029497 2,3-bis(3'-hydroxybenzyl)butyrolactone
  • C016403 2,4-dinitrotoluene
  • C027576 4-hydroxy-2-nonenal
  • C549753 5,7,3'-trihydroxy-3,4'-dimethoxyflavone
  • C464660 6-ethylchenodeoxycholic acid
  • D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide
          more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 16.81 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 53.17 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -130.60302-0.432 Picture PostScript Text
3' UTR -317.30958-0.331 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001766 - TF_fork_head
IPR018122 - TF_fork_head_CS
IPR011991 - WHTH_trsnscrt_rep_DNA-bd

Pfam Domains:
PF00250 - Forkhead domain

SCOP Domains:
46785 - "Winged helix" DNA-binding domain

ModBase Predicted Comparative 3D Structure on Q53Y49
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGDEnsembl   
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003677 DNA binding
GO:0003700 transcription factor activity, sequence-specific DNA binding
GO:0043565 sequence-specific DNA binding

Biological Process:
GO:0006355 regulation of transcription, DNA-templated

Cellular Component:
GO:0005634 nucleus


-  Descriptions from all associated GenBank mRNAs
  BC035437 - Homo sapiens forkhead box M1, mRNA (cDNA clone IMAGE:4155178).
L16783 - Human putative M phase phosphoprotein 2 (MPP2) mRNA, complete cds.
U74613 - Homo sapiens forkhead box M1B (FOXM1B) mRNA, complete cds.
U74612 - Homo sapiens forkhead box M1A (FOXM1A) mRNA, complete cds.
U83113 - Human INS-1 winged-helix homolog mRNA, complete cds.
BC012863 - Homo sapiens forkhead box M1, mRNA (cDNA clone MGC:9577 IMAGE:3881055), complete cds.
BC006192 - Homo sapiens forkhead box M1, mRNA (cDNA clone MGC:10704 IMAGE:3833837), complete cds.
BC006529 - Homo sapiens forkhead box M1, mRNA (cDNA clone MGC:10705 IMAGE:3834244), complete cds.
JD404985 - Sequence 386009 from Patent EP1572962.
JD338490 - Sequence 319514 from Patent EP1572962.
JD133911 - Sequence 114935 from Patent EP1572962.
JD294683 - Sequence 275707 from Patent EP1572962.
JD181454 - Sequence 162478 from Patent EP1572962.
JD398103 - Sequence 379127 from Patent EP1572962.
JD287528 - Sequence 268552 from Patent EP1572962.
JD026314 - Sequence 7338 from Patent EP1572962.
JD036252 - Sequence 17276 from Patent EP1572962.
JD501535 - Sequence 482559 from Patent EP1572962.
JD287107 - Sequence 268131 from Patent EP1572962.
AK291206 - Homo sapiens cDNA FLJ77127 complete cds, highly similar to Homo sapiens forkhead box M1 (FOXM1), transcript variant 3, mRNA.
JD297519 - Sequence 278543 from Patent EP1572962.
JD235544 - Sequence 216568 from Patent EP1572962.
JD353486 - Sequence 334510 from Patent EP1572962.
JD508100 - Sequence 489124 from Patent EP1572962.
JD225126 - Sequence 206150 from Patent EP1572962.
JD193350 - Sequence 174374 from Patent EP1572962.
AY542306 - Homo sapiens PIG29 mRNA, complete cds.
JD310246 - Sequence 291270 from Patent EP1572962.
JD374770 - Sequence 355794 from Patent EP1572962.
BT006986 - Homo sapiens forkhead box M1 mRNA, complete cds.
LT978474 - Homo sapiens mRNA for a novel forkhead box M1 isoform FOXM1D (FOXM1 gene).
LT978475 - Homo sapiens mRNA for FOXM1A (FOXM1 gene).
LT978476 - Homo sapiens mRNA for FOXM1B (FOXM1 gene).
LT978477 - Homo sapiens mRNA for FOXM1C (FOXM1 gene).
LT978478 - Homo sapiens mRNA for FOXM1A (FOXM1 gene).
MG600229 - Homo sapiens forkhead box M1-D (FOXM1) mRNA, complete cds, alternatively spliced.
AK313845 - Homo sapiens cDNA, FLJ94473.
JF432495 - Synthetic construct Homo sapiens clone IMAGE:100073716 forkhead box M1 (FOXM1) gene, encodes complete protein.
KJ891182 - Synthetic construct Homo sapiens clone ccsbBroadEn_00576 FOXM1 gene, encodes complete protein.
KJ905746 - Synthetic construct Homo sapiens clone ccsbBroadEn_15416 FOXM1 gene, encodes complete protein.
AB527696 - Synthetic construct DNA, clone: pF1KB6289, Homo sapiens FOXM1 gene for forkhead box M1, without stop codon, in Flexi system.
CU680424 - Synthetic construct Homo sapiens gateway clone IMAGE:100017486 5' read FOXM1 mRNA.

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000359843.1, ENST00000359843.2, ENST00000359843.3, ENST00000359843.4, ENST00000359843.5, ENST00000359843.6, ENST00000359843.7, FOXM1 , hCG_1731745 , NM_021953, Q53Y49, Q53Y49_HUMAN, uc318bgb.1, uc318bgb.2
UCSC ID: ENST00000359843.8_12
RefSeq Accession: NM_021953.4
Protein: Q53Y49

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.