Human Gene FOXM1 (ENST00000359843.8_12) from GENCODE V47lift37

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Description: forkhead box M1, transcript variant 2 (from RefSeq NM_021953.4)
Gencode Transcript: ENST00000359843.8_12
Gencode Gene: ENSG00000111206.13_14
Transcript (Including UTRs)
Position: hg19 chr12:2,966,846-2,986,340 Size: 19,495 Total Exon Count: 9 Strand: -
Coding Region
Position: hg19 chr12:2,967,804-2,983,644 Size: 15,841 Coding Exon Count: 8

Page Index	Sequence and Links	UniProtKB Comments	Primers	MalaCards	CTD
Gene Alleles	RNA-Seq Expression	Microarray Expression	RNA Structure	Protein Structure	Other Species
GO Annotations	mRNA Descriptions	Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr12:2,966,846-2,986,340)			mRNA (may differ from genome)		Protein (763 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
HGNC	Malacards	MGI	OMIM	PubMed	UniProtKB
Wikipedia	BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: Q53Y49_HUMAN DESCRIPTION: SubName: Full=Forkhead box M1; SubName: Full=Forkhead box M1, isoform CRA_a; SubName: Full=PIG29; SIMILARITY: Contains 1 fork-head DNA-binding domain.

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

MalaCards Disease Associations


	MalaCards Gene Search: FOXM1 Diseases sorted by gene-association score: meckel's diverticulum (13), balanoposthitis (7), cardiomyopathy, hypertrophic, 2 (5), cervix carcinoma (5), maturity-onset diabetes of the young (3), hepatocellular carcinoma (2), lung cancer susceptibility 3 (1), diabetes mellitus, insulin-dependent (1)

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene D013749 Tetrachlorodibenzodioxin D001564 Benzo(a)pyrene D002945 Cisplatin C028474 1,4-bis(2-(3,5-dichloropyridyloxy))benzene C029497 2,3-bis(3'-hydroxybenzyl)butyrolactone C016403 2,4-dinitrotoluene C027576 4-hydroxy-2-nonenal C549753 5,7,3'-trihydroxy-3,4'-dimethoxyflavone C464660 6-ethylchenodeoxycholic acid D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide C547126 AZM551248 D000082 Acetaminophen D016604 Aflatoxin B1 D002084 Butylated Hydroxytoluene D002110 Caffeine D002117 Calcitriol D002251 Carbon Tetrachloride D002635 Chenodeoxycholic Acid D002706 Chlordan D002794 Choline D003300 Copper D019327 Copper Sulfate D003375 Coumestrol D016572 Cyclosporine D004052 Diethylnitrosamine D004958 Estradiol D005492 Folic Acid D006861 Hydrogen Peroxide D008070 Lipopolysaccharides D008154 Lucanthone D008715 Methionine D008748 Methylcholanthrene C558013 NSC 689534 D010634 Phenobarbital D048789 Phytoestrogens D010894 Piroxicam D011285 Pregnenolone Carbonitrile D011794 Quercetin D020123 Sirolimus D012999 Soman D013629 Tamoxifen D013739 Testosterone D013759 Tetrahydrocannabinol D013893 Thiram D014212 Tretinoin D014520 Urethane D014810 Vitamin E D024483 Vitamin K 3 C006780 bisphenol A C515564 bromovanin C018021 cobaltous chloride C488369 dasatinib C070081 fulvestrant C006253 pirinixic acid C045950 propiconazole C059514 resveratrol C025462 sulindac sulfide D020122 tert-Butylhydroperoxide C015559 trimellitic anhydride C057693 troglitazone

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 16.81 RPKM in Cells - EBV-transformed lymphocytes Total median expression: 53.17 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-130.60	302	-0.432	Picture	PostScript	Text
3' UTR	-317.30	958	-0.331	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR001766 - TF_fork_head
IPR018122 - TF_fork_head_CS
IPR011991 - WHTH_trsnscrt_rep_DNA-bd

Pfam Domains:
PF00250 - Forkhead domain

SCOP Domains:
46785 - "Winged helix" DNA-binding domain

ModBase Predicted Comparative 3D Structure on Q53Y49


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog
Gene Details	Gene Details
Gene Sorter	Gene Sorter
	RGD	Ensembl

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0003677 DNA binding GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0043565 sequence-specific DNA binding Biological Process: GO:0006355 regulation of transcription, DNA-templated Cellular Component: GO:0005634 nucleus

Descriptions from all associated GenBank mRNAs


	BC035437 - Homo sapiens forkhead box M1, mRNA (cDNA clone IMAGE:4155178). L16783 - Human putative M phase phosphoprotein 2 (MPP2) mRNA, complete cds. U74613 - Homo sapiens forkhead box M1B (FOXM1B) mRNA, complete cds. U74612 - Homo sapiens forkhead box M1A (FOXM1A) mRNA, complete cds. U83113 - Human INS-1 winged-helix homolog mRNA, complete cds. BC012863 - Homo sapiens forkhead box M1, mRNA (cDNA clone MGC:9577 IMAGE:3881055), complete cds. BC006192 - Homo sapiens forkhead box M1, mRNA (cDNA clone MGC:10704 IMAGE:3833837), complete cds. BC006529 - Homo sapiens forkhead box M1, mRNA (cDNA clone MGC:10705 IMAGE:3834244), complete cds. JD404985 - Sequence 386009 from Patent EP1572962. JD338490 - Sequence 319514 from Patent EP1572962. JD133911 - Sequence 114935 from Patent EP1572962. JD294683 - Sequence 275707 from Patent EP1572962. JD181454 - Sequence 162478 from Patent EP1572962. JD398103 - Sequence 379127 from Patent EP1572962. JD287528 - Sequence 268552 from Patent EP1572962. JD026314 - Sequence 7338 from Patent EP1572962. JD036252 - Sequence 17276 from Patent EP1572962. JD501535 - Sequence 482559 from Patent EP1572962. JD287107 - Sequence 268131 from Patent EP1572962. AK291206 - Homo sapiens cDNA FLJ77127 complete cds, highly similar to Homo sapiens forkhead box M1 (FOXM1), transcript variant 3, mRNA. JD297519 - Sequence 278543 from Patent EP1572962. JD235544 - Sequence 216568 from Patent EP1572962. JD353486 - Sequence 334510 from Patent EP1572962. JD508100 - Sequence 489124 from Patent EP1572962. JD225126 - Sequence 206150 from Patent EP1572962. JD193350 - Sequence 174374 from Patent EP1572962. AY542306 - Homo sapiens PIG29 mRNA, complete cds. JD310246 - Sequence 291270 from Patent EP1572962. JD374770 - Sequence 355794 from Patent EP1572962. BT006986 - Homo sapiens forkhead box M1 mRNA, complete cds. LT978474 - Homo sapiens mRNA for a novel forkhead box M1 isoform FOXM1D (FOXM1 gene). LT978475 - Homo sapiens mRNA for FOXM1A (FOXM1 gene). LT978476 - Homo sapiens mRNA for FOXM1B (FOXM1 gene). LT978477 - Homo sapiens mRNA for FOXM1C (FOXM1 gene). LT978478 - Homo sapiens mRNA for FOXM1A (FOXM1 gene). MG600229 - Homo sapiens forkhead box M1-D (FOXM1) mRNA, complete cds, alternatively spliced. AK313845 - Homo sapiens cDNA, FLJ94473. JF432495 - Synthetic construct Homo sapiens clone IMAGE:100073716 forkhead box M1 (FOXM1) gene, encodes complete protein. KJ891182 - Synthetic construct Homo sapiens clone ccsbBroadEn_00576 FOXM1 gene, encodes complete protein. KJ905746 - Synthetic construct Homo sapiens clone ccsbBroadEn_15416 FOXM1 gene, encodes complete protein. AB527696 - Synthetic construct DNA, clone: pF1KB6289, Homo sapiens FOXM1 gene for forkhead box M1, without stop codon, in Flexi system. CU680424 - Synthetic construct Homo sapiens gateway clone IMAGE:100017486 5' read FOXM1 mRNA.

Other Names for This Gene


	Alternate Gene Symbols: ENST00000359843.1, ENST00000359843.2, ENST00000359843.3, ENST00000359843.4, ENST00000359843.5, ENST00000359843.6, ENST00000359843.7, FOXM1 , hCG_1731745 , NM_021953, Q53Y49, Q53Y49_HUMAN, uc318bgb.1, uc318bgb.2 UCSC ID: ENST00000359843.8_12 RefSeq Accession: NM_021953.4 Protein: Q53Y49

Gene Model Information


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Methods, Credits, and Use Restrictions


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