Human Gene FPR2 (ENST00000340023.7_4) from GENCODE V47lift37
  Description: formyl peptide receptor 2, transcript variant 2 (from RefSeq NM_001005738.2)
Gencode Transcript: ENST00000340023.7_4
Gencode Gene: ENSG00000171049.9_11
Transcript (Including UTRs)
   Position: hg19 chr19:52,264,433-52,273,784 Size: 9,352 Total Exon Count: 2 Strand: +
Coding Region
   Position: hg19 chr19:52,271,912-52,272,967 Size: 1,056 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr19:52,264,433-52,273,784)mRNA (may differ from genome)Protein (351 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
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HGNCMalacardsMGIOMIMPubMedReactome
UniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: FPR2_HUMAN
DESCRIPTION: RecName: Full=N-formyl peptide receptor 2; AltName: Full=FMLP-related receptor I; Short=FMLP-R-I; AltName: Full=Formyl peptide receptor-like 1; AltName: Full=HM63; AltName: Full=Lipoxin A4 receptor; Short=LXA4 receptor; AltName: Full=RFP;
FUNCTION: Low affinity receptor for N-formyl-methionyl peptides, which are powerful neutrophils chemotactic factors. Binding of FMLP to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. The activation of LXA4R could result in an anti-inflammatory outcome counteracting the actions of proinflammatory signals such as LTB4 (leukotriene B4).
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
TISSUE SPECIFICITY: Expressed abundantly in the lung and neutrophils. Also found in the spleen and testis.
SIMILARITY: Belongs to the G-protein coupled receptor 1 family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: FPR2
Diseases sorted by gene-association score: prion disease (5)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 45.67 RPKM in Whole Blood
Total median expression: 62.06 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -17.0065-0.262 Picture PostScript Text
3' UTR -190.50817-0.233 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000276 - 7TM_GPCR_Rhodpsn
IPR000826 - Frt_met_rcpt
IPR017452 - GPCR_Rhodpsn_supfam

Pfam Domains:
PF00001 - 7 transmembrane receptor (rhodopsin family)

SCOP Domains:
81321 - Family A G protein-coupled receptor-like

ModBase Predicted Comparative 3D Structure on P25090
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
      
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004871 signal transducer activity
GO:0004875 complement receptor activity
GO:0004930 G-protein coupled receptor activity
GO:0004982 N-formyl peptide receptor activity
GO:0005124 scavenger receptor binding
GO:0038024 cargo receptor activity

Biological Process:
GO:0001774 microglial cell activation
GO:0001934 positive regulation of protein phosphorylation
GO:0002430 complement receptor mediated signaling pathway
GO:0006898 receptor-mediated endocytosis
GO:0006935 chemotaxis
GO:0006954 inflammatory response
GO:0007155 cell adhesion
GO:0007165 signal transduction
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0019722 calcium-mediated signaling
GO:0032930 positive regulation of superoxide anion generation
GO:0043312 neutrophil degranulation
GO:0048143 astrocyte activation
GO:0050900 leukocyte migration
GO:0050918 positive chemotaxis
GO:0060326 cell chemotaxis
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0090026 positive regulation of monocyte chemotaxis
GO:1904646 cellular response to beta-amyloid

Cellular Component:
GO:0005622 intracellular
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0035579 specific granule membrane
GO:0070821 tertiary granule membrane
GO:0101003 ficolin-1-rich granule membrane


-  Descriptions from all associated GenBank mRNAs
  BC071722 - Homo sapiens formyl peptide receptor 2, mRNA (cDNA clone MGC:88032 IMAGE:5212947), complete cds.
M88107 - Human formyl peptide receptor (FPR2) mRNA, complete cds.
D10922 - Homo sapiens HM63 mRNA for FMLP-related receptor, complete cds.
AK290557 - Homo sapiens cDNA FLJ75645 complete cds, highly similar to Homo sapiens formyl peptide receptor-like 1 (FPRL1), transcript variant 2, mRNA.
M84562 - Human formyl peptide receptor-like receptor (FPRL1) mRNA, complete cds.
X63819 - H.sapiens mRNA for Lipoxin A4 receptor.
U81501 - Human lipoxin A4 receptor mRNA, complete cds.
BC029125 - Homo sapiens formyl peptide receptor 2, mRNA (cDNA clone MGC:34599 IMAGE:5180065), complete cds.
JD274475 - Sequence 255499 from Patent EP1572962.
DQ892105 - Synthetic construct clone IMAGE:100004735; FLH183077.01X; RZPDo839F08140D formyl peptide receptor-like 1 (FPRL1) gene, encodes complete protein.
DQ895299 - Synthetic construct Homo sapiens clone IMAGE:100009759; FLH183073.01L; RZPDo839F08139D formyl peptide receptor-like 1 (FPRL1) gene, encodes complete protein.
KJ891194 - Synthetic construct Homo sapiens clone ccsbBroadEn_00588 FPR2 gene, encodes complete protein.
AF054013 - Homo sapiens lipoxin A4 receptor mRNA, complete cds.
M76672 - Human FMLP-related receptor II (FMLP R II) mRNA, complete cds.
JD359508 - Sequence 340532 from Patent EP1572962.
JD179252 - Sequence 160276 from Patent EP1572962.
JD509003 - Sequence 490027 from Patent EP1572962.
JD248776 - Sequence 229800 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein P25090 (Reactome details) participates in the following event(s):

R-HSA-391913 FPR2 binds FPR2 ligands
R-HSA-749454 The Ligand:GPCR:Gi complex dissociates
R-HSA-749452 The Ligand:GPCR:Gq complex dissociates
R-HSA-6799350 Exocytosis of specific granule membrane proteins
R-HSA-6798747 Exocytosis of tertiary granule membrane proteins
R-HSA-6800426 Exocytosis of ficolin-rich granule membrane proteins
R-HSA-749456 Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi
R-HSA-749448 Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq
R-HSA-380073 Liganded Gi-activating GPCR acts as a GEF for Gi
R-HSA-379048 Liganded Gq/11-activating GPCRs act as GEFs for Gq/11
R-HSA-444473 Formyl peptide receptors bind formyl peptides and many other ligands
R-HSA-418594 G alpha (i) signalling events
R-HSA-416476 G alpha (q) signalling events
R-HSA-6798695 Neutrophil degranulation
R-HSA-375276 Peptide ligand-binding receptors
R-HSA-388396 GPCR downstream signalling
R-HSA-168249 Innate Immune System
R-HSA-373076 Class A/1 (Rhodopsin-like receptors)
R-HSA-372790 Signaling by GPCR
R-HSA-168256 Immune System
R-HSA-500792 GPCR ligand binding
R-HSA-162582 Signal Transduction

-  Other Names for This Gene
  Alternate Gene Symbols: A8K3E2, ENST00000340023.1, ENST00000340023.2, ENST00000340023.3, ENST00000340023.4, ENST00000340023.5, ENST00000340023.6, FPR2_HUMAN, FPRH1, FPRL1, LXA4R, NM_001005738, P25090, uc317vnt.1, uc317vnt.2
UCSC ID: ENST00000340023.7_4
RefSeq Accession: NM_001005738.2
Protein: P25090 (aka FPR2_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.