Human Gene FSCN1 (ENST00000382361.8_4) from GENCODE V47lift37
  Description: fascin actin-bundling protein 1 (from RefSeq NM_003088.4)
Gencode Transcript: ENST00000382361.8_4
Gencode Gene: ENSG00000075618.18_7
Transcript (Including UTRs)
   Position: hg19 chr7:5,632,447-5,646,286 Size: 13,840 Total Exon Count: 5 Strand: +
Coding Region
   Position: hg19 chr7:5,632,568-5,645,105 Size: 12,538 Coding Exon Count: 5 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr7:5,632,447-5,646,286)mRNA (may differ from genome)Protein (493 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedReactome
UniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: FSCN1_HUMAN
DESCRIPTION: RecName: Full=Fascin; AltName: Full=55 kDa actin-bundling protein; AltName: Full=Singed-like protein; AltName: Full=p55;
FUNCTION: Organizes filamentous actin into bundles with a minimum of 4.1:1 actin/fascin ratio. Plays a role in the organization of actin filament bundles and the formation of microspikes, membrane ruffles, and stress fibers. Important for the formation of a diverse set of cell protrusions, such as filopodia, and for cell motility and migration.
SUBUNIT: Associates with beta-catenin. Interacts with PLXNB3.
INTERACTION: Q9BXW9:FANCD2; NbExp=6; IntAct=EBI-351076, EBI-359343; P40692:MLH1; NbExp=7; IntAct=EBI-351076, EBI-744248;
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton. Cell projection, filopodium. Cell projection, invadopodium. Cytoplasm, cytosol. Note=In glioma cells, partially colocalizes with F-actin stress fibers in the cytosol.
TISSUE SPECIFICITY: Ubiquitous.
DOMAIN: Composed of four beta-trefoil domains.
PTM: Phosphorylation on Ser-39 inhibits the actin-binding ability of fascin.
SIMILARITY: Belongs to the fascin family.
WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/FSCN1ID44342ch7p22.html";

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: FSCN1
Diseases sorted by gene-association score: juvenile xanthogranuloma (12), hodgkin lymphoma (7), rosai-dorfman disease (5), hodgkin's lymphoma, lymphocytic-histiocytic predominance (4), ovarian cancer, somatic (4), alk+ histiocytosis (3), papilloma (3), histiocytosis (3), deafness, autosomal recessive 28 (3), esophageal cancer (2), deafness, autosomal recessive 36 (2), dendritic cell tumor (2), lung cancer (2), pancreatic cancer (2), histiocytic sarcoma (2), hodgkin's lymphoma, lymphocytic depletion (2), colloid carcinoma of the pancreas (1), baraitser-winter syndrome (1), cystitis cystica (1), serine deficiency (1), reticulohistiocytic granuloma (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 115.01 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 1245.06 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -57.20121-0.473 Picture PostScript Text
3' UTR -499.001181-0.423 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR008999 - Actin_cross-linking
IPR024703 - Fascin
IPR022768 - Fascin-domain

Pfam Domains:
PF06268 - Fascin domain

SCOP Domains:
50353 - Cytokine
50370 - Ricin B-like lectins
50405 - Actin-crosslinking proteins

Protein Data Bank (PDB) 3-D Structure
MuPIT help
1DFC - X-ray MuPIT 3LLP - X-ray MuPIT 3O8K - X-ray 3P53 - X-ray MuPIT


ModBase Predicted Comparative 3D Structure on Q16658
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details Gene Details  
Gene SorterGene Sorter Gene Sorter  
 RGDEnsembl   
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003723 RNA binding
GO:0003779 actin binding
GO:0005515 protein binding
GO:0008144 drug binding
GO:0030674 protein binding, bridging
GO:0045296 cadherin binding
GO:0051015 actin filament binding

Biological Process:
GO:0007015 actin filament organization
GO:0007043 cell-cell junction assembly
GO:0008283 cell proliferation
GO:0009653 anatomical structure morphogenesis
GO:0010592 positive regulation of lamellipodium assembly
GO:0016477 cell migration
GO:0019221 cytokine-mediated signaling pathway
GO:0030035 microspike assembly
GO:0030036 actin cytoskeleton organization
GO:0032534 regulation of microvillus assembly
GO:0032956 regulation of actin cytoskeleton organization
GO:0035089 establishment of apical/basal cell polarity
GO:0048870 cell motility
GO:0051017 actin filament bundle assembly
GO:0051491 positive regulation of filopodium assembly
GO:0071803 positive regulation of podosome assembly
GO:0090091 positive regulation of extracellular matrix disassembly

Cellular Component:
GO:0001725 stress fiber
GO:0001726 ruffle
GO:0002102 podosome
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005902 microvillus
GO:0005911 cell-cell junction
GO:0015629 actin cytoskeleton
GO:0030027 lamellipodium
GO:0030054 cell junction
GO:0030175 filopodium
GO:0030426 growth cone
GO:0031253 cell projection membrane
GO:0031941 filamentous actin
GO:0042995 cell projection
GO:0043209 myelin sheath
GO:0044393 microspike
GO:0070062 extracellular exosome
GO:0071437 invadopodium


-  Descriptions from all associated GenBank mRNAs
  LF384069 - JP 2014500723-A/191572: Polycomb-Associated Non-Coding RNAs.
AK095254 - Homo sapiens cDNA FLJ37935 fis, clone CTONG2005290, highly similar to FASCIN.
AK316607 - Homo sapiens cDNA, FLJ96825, Homo sapiens fascin homolog 1, actin-bundling protein(Strongylocentrotus purpuratus) (FSCN1), mRNA.
BC006304 - Homo sapiens fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus), mRNA (cDNA clone MGC:13298 IMAGE:4100996), complete cds.
U03057 - Human actin bundling protein (HSN) mRNA, complete cds.
BC007948 - Homo sapiens fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus), mRNA (cDNA clone MGC:14372 IMAGE:4299524), complete cds.
U09873 - Human actin bundling protein mRNA, complete cds.
BC000521 - Homo sapiens fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus), mRNA (cDNA clone MGC:8587 IMAGE:2961047), complete cds.
BC007539 - Homo sapiens fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus), mRNA (cDNA clone IMAGE:3029477), partial cds.
BC007988 - Homo sapiens fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus), mRNA (cDNA clone MGC:3899 IMAGE:2961047), complete cds.
GQ900932 - Homo sapiens clone HEL-T-44 epididymis secretory sperm binding protein mRNA, complete cds.
DQ894580 - Synthetic construct Homo sapiens clone IMAGE:100009040; FLH176599.01L; RZPDo839F03121D fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus) (FSCN1) gene, encodes complete protein.
DQ891402 - Synthetic construct clone IMAGE:100004032; FLH176601.01X; RZPDo839F03122D fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus) (FSCN1) gene, encodes complete protein.
CU674252 - Synthetic construct Homo sapiens gateway clone IMAGE:100020733 5' read FSCN1 mRNA.
KJ892171 - Synthetic construct Homo sapiens clone ccsbBroadEn_01565 FSCN1 gene, encodes complete protein.
BT006636 - Homo sapiens fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus) mRNA, complete cds.
BC007643 - Homo sapiens, Similar to singed (Drosophila)-like (sea urchin fascin homolog like), clone IMAGE:3534502, mRNA, partial cds.
MA619646 - JP 2018138019-A/191572: Polycomb-Associated Non-Coding RNAs.
JD406966 - Sequence 387990 from Patent EP1572962.
JD461598 - Sequence 442622 from Patent EP1572962.
JD404626 - Sequence 385650 from Patent EP1572962.
JD381193 - Sequence 362217 from Patent EP1572962.
LF360089 - JP 2014500723-A/167592: Polycomb-Associated Non-Coding RNAs.
JD540499 - Sequence 521523 from Patent EP1572962.
MA595666 - JP 2018138019-A/167592: Polycomb-Associated Non-Coding RNAs.
AK095830 - Homo sapiens cDNA FLJ38511 fis, clone HCHON2000417, highly similar to FASCIN.
LF360095 - JP 2014500723-A/167598: Polycomb-Associated Non-Coding RNAs.
LF360096 - JP 2014500723-A/167599: Polycomb-Associated Non-Coding RNAs.
LF360097 - JP 2014500723-A/167600: Polycomb-Associated Non-Coding RNAs.
LF360098 - JP 2014500723-A/167601: Polycomb-Associated Non-Coding RNAs.
AK125295 - Homo sapiens cDNA FLJ43305 fis, clone NT2NE2005890.
LF360099 - JP 2014500723-A/167602: Polycomb-Associated Non-Coding RNAs.
JD184349 - Sequence 165373 from Patent EP1572962.
JD093730 - Sequence 74754 from Patent EP1572962.
JD080419 - Sequence 61443 from Patent EP1572962.
JD473820 - Sequence 454844 from Patent EP1572962.
JD407790 - Sequence 388814 from Patent EP1572962.
JD019605 - Sequence 629 from Patent EP1572962.
LF360100 - JP 2014500723-A/167603: Polycomb-Associated Non-Coding RNAs.
JD490928 - Sequence 471952 from Patent EP1572962.
JD048406 - Sequence 29430 from Patent EP1572962.
JD418381 - Sequence 399405 from Patent EP1572962.
JD030701 - Sequence 11725 from Patent EP1572962.
JD525338 - Sequence 506362 from Patent EP1572962.
JD191026 - Sequence 172050 from Patent EP1572962.
JD361484 - Sequence 342508 from Patent EP1572962.
JD205084 - Sequence 186108 from Patent EP1572962.
JD105785 - Sequence 86809 from Patent EP1572962.
JD256156 - Sequence 237180 from Patent EP1572962.
JD513770 - Sequence 494794 from Patent EP1572962.
JD252476 - Sequence 233500 from Patent EP1572962.
JD370014 - Sequence 351038 from Patent EP1572962.
JD143288 - Sequence 124312 from Patent EP1572962.
JD425642 - Sequence 406666 from Patent EP1572962.
JD268470 - Sequence 249494 from Patent EP1572962.
JD310046 - Sequence 291070 from Patent EP1572962.
LF360101 - JP 2014500723-A/167604: Polycomb-Associated Non-Coding RNAs.
MA595672 - JP 2018138019-A/167598: Polycomb-Associated Non-Coding RNAs.
MA595673 - JP 2018138019-A/167599: Polycomb-Associated Non-Coding RNAs.
MA595674 - JP 2018138019-A/167600: Polycomb-Associated Non-Coding RNAs.
MA595675 - JP 2018138019-A/167601: Polycomb-Associated Non-Coding RNAs.
MA595676 - JP 2018138019-A/167602: Polycomb-Associated Non-Coding RNAs.
MA595677 - JP 2018138019-A/167603: Polycomb-Associated Non-Coding RNAs.
MA595678 - JP 2018138019-A/167604: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q16658 (Reactome details) participates in the following event(s):

R-HSA-6785807 Interleukin-4 and 13 signaling
R-HSA-449147 Signaling by Interleukins
R-HSA-1280215 Cytokine Signaling in Immune system
R-HSA-168256 Immune System

-  Other Names for This Gene
  Alternate Gene Symbols: A6NI89, B2RE97, ENST00000382361.1, ENST00000382361.2, ENST00000382361.3, ENST00000382361.4, ENST00000382361.5, ENST00000382361.6, ENST00000382361.7, FAN1, FSCN1_HUMAN, HSN, NM_003088, Q16658, Q96IC5, Q96IH1, Q9BRF1, SNL, uc318qui.1, uc318qui.2
UCSC ID: ENST00000382361.8_4
RefSeq Accession: NM_003088.4
Protein: Q16658 (aka FSCN1_HUMAN or FSC1_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.