Human Gene FSCN1 (ENST00000382361.8_4) from GENCODE V47lift37
Description: fascin actin-bundling protein 1 (from RefSeq NM_003088.4)
Gencode Transcript: ENST00000382361.8_4
Gencode Gene: ENSG00000075618.18_7
Transcript (Including UTRs)
Position: hg19 chr7:5,632,447-5,646,286 Size: 13,840 Total Exon Count: 5 Strand: +
Coding Region
Position: hg19 chr7:5,632,568-5,645,105 Size: 12,538 Coding Exon Count: 5
Data last updated at UCSC: 2024-08-22 23:36:26
Sequence and Links to Tools and Databases
Comments and Description Text from UniProtKB
ID: FSCN1_HUMAN
DESCRIPTION: RecName: Full=Fascin; AltName: Full=55 kDa actin-bundling protein; AltName: Full=Singed-like protein; AltName: Full=p55;
FUNCTION: Organizes filamentous actin into bundles with a minimum of 4.1:1 actin/fascin ratio. Plays a role in the organization of actin filament bundles and the formation of microspikes, membrane ruffles, and stress fibers. Important for the formation of a diverse set of cell protrusions, such as filopodia, and for cell motility and migration.SUBUNIT: Associates with beta-catenin. Interacts with PLXNB3.INTERACTION: Q9BXW9:FANCD2; NbExp=6; IntAct=EBI-351076, EBI-359343; P40692:MLH1; NbExp=7; IntAct=EBI-351076, EBI-744248;SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton. Cell projection, filopodium. Cell projection, invadopodium. Cytoplasm, cytosol. Note=In glioma cells, partially colocalizes with F-actin stress fibers in the cytosol.TISSUE SPECIFICITY: Ubiquitous.DOMAIN: Composed of four beta-trefoil domains.PTM: Phosphorylation on Ser-39 inhibits the actin-binding ability of fascin.SIMILARITY: Belongs to the fascin family.WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/FSCN1ID44342ch7p22.html";
Primer design for this transcript
MalaCards Disease Associations
MalaCards Gene Search: FSCN1
Diseases sorted by gene-association score: juvenile xanthogranuloma (12), hodgkin lymphoma (7), rosai-dorfman disease (5), hodgkin's lymphoma, lymphocytic-histiocytic predominance (4), ovarian cancer, somatic (4), alk+ histiocytosis (3), papilloma (3), histiocytosis (3), deafness, autosomal recessive 28 (3), esophageal cancer (2), deafness, autosomal recessive 36 (2), dendritic cell tumor (2), lung cancer (2), pancreatic cancer (2), histiocytic sarcoma (2), hodgkin's lymphoma, lymphocytic depletion (2), colloid carcinoma of the pancreas (1), baraitser-winter syndrome (1), cystitis cystica (1), serine deficiency (1), reticulohistiocytic granuloma (1)
Comparative Toxicogenomics Database (CTD)
The following chemicals interact with this gene
Common Gene Haplotype Alleles
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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
Microarray Expression Data
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mRNA Secondary Structure of 3' and 5' UTRs
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
InterPro Domains: Graphical view of domain structure IPR008999 - Actin_cross-linking
IPR024703 - Fascin
IPR022768 - Fascin-domain
Pfam Domains: PF06268 - Fascin domain
SCOP Domains: 50353 - Cytokine
50370 - Ricin B-like lectins
50405 - Actin-crosslinking proteins
Protein Data Bank (PDB) 3-D Structure
ModBase Predicted Comparative 3D Structure on Q16658
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Descriptions from all associated GenBank mRNAs
LF384069 - JP 2014500723-A/191572: Polycomb-Associated Non-Coding RNAs.AK095254 - Homo sapiens cDNA FLJ37935 fis, clone CTONG2005290, highly similar to FASCIN.AK316607 - Homo sapiens cDNA, FLJ96825, Homo sapiens fascin homolog 1, actin-bundling protein(Strongylocentrotus purpuratus) (FSCN1), mRNA.BC006304 - Homo sapiens fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus), mRNA (cDNA clone MGC:13298 IMAGE:4100996), complete cds.U03057 - Human actin bundling protein (HSN) mRNA, complete cds.BC007948 - Homo sapiens fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus), mRNA (cDNA clone MGC:14372 IMAGE:4299524), complete cds.U09873 - Human actin bundling protein mRNA, complete cds.BC000521 - Homo sapiens fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus), mRNA (cDNA clone MGC:8587 IMAGE:2961047), complete cds.BC007539 - Homo sapiens fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus), mRNA (cDNA clone IMAGE:3029477), partial cds.BC007988 - Homo sapiens fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus), mRNA (cDNA clone MGC:3899 IMAGE:2961047), complete cds.GQ900932 - Homo sapiens clone HEL-T-44 epididymis secretory sperm binding protein mRNA, complete cds.DQ894580 - Synthetic construct Homo sapiens clone IMAGE:100009040; FLH176599.01L; RZPDo839F03121D fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus) (FSCN1) gene, encodes complete protein.DQ891402 - Synthetic construct clone IMAGE:100004032; FLH176601.01X; RZPDo839F03122D fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus) (FSCN1) gene, encodes complete protein.CU674252 - Synthetic construct Homo sapiens gateway clone IMAGE:100020733 5' read FSCN1 mRNA.KJ892171 - Synthetic construct Homo sapiens clone ccsbBroadEn_01565 FSCN1 gene, encodes complete protein.BT006636 - Homo sapiens fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus) mRNA, complete cds.BC007643 - Homo sapiens, Similar to singed (Drosophila)-like (sea urchin fascin homolog like), clone IMAGE:3534502, mRNA, partial cds.MA619646 - JP 2018138019-A/191572: Polycomb-Associated Non-Coding RNAs.JD406966 - Sequence 387990 from Patent EP1572962.JD461598 - Sequence 442622 from Patent EP1572962.JD404626 - Sequence 385650 from Patent EP1572962.JD381193 - Sequence 362217 from Patent EP1572962.LF360089 - JP 2014500723-A/167592: Polycomb-Associated Non-Coding RNAs.JD540499 - Sequence 521523 from Patent EP1572962.MA595666 - JP 2018138019-A/167592: Polycomb-Associated Non-Coding RNAs.AK095830 - Homo sapiens cDNA FLJ38511 fis, clone HCHON2000417, highly similar to FASCIN.LF360095 - JP 2014500723-A/167598: Polycomb-Associated Non-Coding RNAs.LF360096 - JP 2014500723-A/167599: Polycomb-Associated Non-Coding RNAs.LF360097 - JP 2014500723-A/167600: Polycomb-Associated Non-Coding RNAs.LF360098 - JP 2014500723-A/167601: Polycomb-Associated Non-Coding RNAs.AK125295 - Homo sapiens cDNA FLJ43305 fis, clone NT2NE2005890.LF360099 - JP 2014500723-A/167602: Polycomb-Associated Non-Coding RNAs.JD184349 - Sequence 165373 from Patent EP1572962.JD093730 - Sequence 74754 from Patent EP1572962.JD080419 - Sequence 61443 from Patent EP1572962.JD473820 - Sequence 454844 from Patent EP1572962.JD407790 - Sequence 388814 from Patent EP1572962.JD019605 - Sequence 629 from Patent EP1572962.LF360100 - JP 2014500723-A/167603: Polycomb-Associated Non-Coding RNAs.JD490928 - Sequence 471952 from Patent EP1572962.JD048406 - Sequence 29430 from Patent EP1572962.JD418381 - Sequence 399405 from Patent EP1572962.JD030701 - Sequence 11725 from Patent EP1572962.JD525338 - Sequence 506362 from Patent EP1572962.JD191026 - Sequence 172050 from Patent EP1572962.JD361484 - Sequence 342508 from Patent EP1572962.JD205084 - Sequence 186108 from Patent EP1572962.JD105785 - Sequence 86809 from Patent EP1572962.JD256156 - Sequence 237180 from Patent EP1572962.JD513770 - Sequence 494794 from Patent EP1572962.JD252476 - Sequence 233500 from Patent EP1572962.JD370014 - Sequence 351038 from Patent EP1572962.JD143288 - Sequence 124312 from Patent EP1572962.JD425642 - Sequence 406666 from Patent EP1572962.JD268470 - Sequence 249494 from Patent EP1572962.JD310046 - Sequence 291070 from Patent EP1572962.LF360101 - JP 2014500723-A/167604: Polycomb-Associated Non-Coding RNAs.MA595672 - JP 2018138019-A/167598: Polycomb-Associated Non-Coding RNAs.MA595673 - JP 2018138019-A/167599: Polycomb-Associated Non-Coding RNAs.MA595674 - JP 2018138019-A/167600: Polycomb-Associated Non-Coding RNAs.MA595675 - JP 2018138019-A/167601: Polycomb-Associated Non-Coding RNAs.MA595676 - JP 2018138019-A/167602: Polycomb-Associated Non-Coding RNAs.MA595677 - JP 2018138019-A/167603: Polycomb-Associated Non-Coding RNAs.MA595678 - JP 2018138019-A/167604: Polycomb-Associated Non-Coding RNAs.
Biochemical and Signaling Pathways
Other Names for This Gene
Alternate Gene Symbols: A6NI89, B2RE97, ENST00000382361.1, ENST00000382361.2, ENST00000382361.3, ENST00000382361.4, ENST00000382361.5, ENST00000382361.6, ENST00000382361.7, FAN1, FSCN1_HUMAN, HSN, NM_003088, Q16658, Q96IC5, Q96IH1, Q9BRF1, SNL, uc318qui.1, uc318qui.2UCSC ID: ENST00000382361.8_4RefSeq Accession: NM_003088.4
Protein: Q16658
(aka FSCN1_HUMAN or FSC1_HUMAN)
Gene Model Information
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for a detailed description of the fields of the table above.
Methods, Credits, and Use Restrictions
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for details on how this gene model was made and data restrictions if any.