Human Gene FST (ENST00000256759.8_11) from GENCODE V47lift37
  Description: follistatin, transcript variant FST344 (from RefSeq NM_013409.3)
Gencode Transcript: ENST00000256759.8_11
Gencode Gene: ENSG00000134363.12_14
Transcript (Including UTRs)
   Position: hg19 chr5:52,776,459-52,782,964 Size: 6,506 Total Exon Count: 6 Strand: +
Coding Region
   Position: hg19 chr5:52,776,622-52,781,863 Size: 5,242 Coding Exon Count: 6 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr5:52,776,459-52,782,964)mRNA (may differ from genome)Protein (344 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedReactome
UniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: FST_HUMAN
DESCRIPTION: RecName: Full=Follistatin; Short=FS; AltName: Full=Activin-binding protein; Flags: Precursor;
FUNCTION: Binds directly to activin and functions as an activin antagonist. Specific inhibitor of the biosynthesis and secretion of pituitary follicle stimulating hormone (FSH).
SUBUNIT: Monomer (Potential).
INTERACTION: P03950:ANG; NbExp=3; IntAct=EBI-1571188, EBI-525291;
SUBCELLULAR LOCATION: Secreted.
TISSUE SPECIFICITY: Isoform 1 is the predominant isoform in serum but is undetectable in follicular fluid.
SIMILARITY: Contains 3 follistatin-like domains.
SIMILARITY: Contains 3 Kazal-like domains.
SIMILARITY: Contains 1 TB (TGF-beta binding) domain.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: FST
Diseases sorted by gene-association score: polycystic ovary syndrome (28), oocyte maturation defect 1 (3), spinal muscular atrophy-4 (2), brachyolmia (1), ovarian mucinous neoplasm (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 14.97 RPKM in Adipose - Subcutaneous
Total median expression: 191.33 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -84.50163-0.518 Picture PostScript Text
3' UTR -227.701101-0.207 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR003645 - Fol_N
IPR015369 - Follistatin/Osteonectin_EGF
IPR002350 - Prot_inh_Kazal
IPR017878 - TB_dom

Pfam Domains:
PF00050 - Kazal-type serine protease inhibitor domain
PF07648 - Kazal-type serine protease inhibitor domain
PF09289 - Follistatin/Osteonectin-like EGF domain

SCOP Domains:
57581 - TB module/8-cys domain
57196 - EGF/Laminin
100895 - Kazal-type serine protease inhibitors

Protein Data Bank (PDB) 3-D Structure
MuPIT help
2B0U - X-ray MuPIT 2P6A - X-ray MuPIT 3HH2 - X-ray MuPIT


ModBase Predicted Comparative 3D Structure on P19883
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details Gene Details  
Gene SorterGene Sorter Gene Sorter  
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004871 signal transducer activity
GO:0005515 protein binding
GO:0043395 heparan sulfate proteoglycan binding
GO:0048185 activin binding

Biological Process:
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0002244 hematopoietic progenitor cell differentiation
GO:0007165 signal transduction
GO:0032926 negative regulation of activin receptor signaling pathway
GO:0051798 positive regulation of hair follicle development

Cellular Component:
GO:0005576 extracellular region


-  Descriptions from all associated GenBank mRNAs
  LF212555 - JP 2014500723-A/20058: Polycomb-Associated Non-Coding RNAs.
LF209921 - JP 2014500723-A/17424: Polycomb-Associated Non-Coding RNAs.
BC004107 - Homo sapiens follistatin, mRNA (cDNA clone MGC:10663 IMAGE:3688745), complete cds.
AB451474 - Homo sapiens FST mRNA for follistatin isoform FST317 precursor, partial cds, clone: FLJ80201SAAF.
AB451330 - Homo sapiens FST mRNA for follistatin isoform FST317 precursor, complete cds, clone: FLJ80201SAAN.
CR541813 - Homo sapiens full open reading frame cDNA clone RZPDo834G1031D for gene FST, follistatin; complete cds, incl. stopcodon.
DQ896745 - Synthetic construct Homo sapiens clone IMAGE:100011205; FLH199428.01L; RZPDo839G0681D follistatin (FST) gene, encodes complete protein.
DQ893433 - Synthetic construct clone IMAGE:100006063; FLH199522.01X; RZPDo839G0682D follistatin (FST) gene, encodes complete protein.
LF332741 - JP 2014500723-A/140244: Polycomb-Associated Non-Coding RNAs.
JD127850 - Sequence 108874 from Patent EP1572962.
JD164539 - Sequence 145563 from Patent EP1572962.
LF332738 - JP 2014500723-A/140241: Polycomb-Associated Non-Coding RNAs.
LQ969314 - Sequence 3 from Patent WO2014198720.
MA448132 - JP 2018138019-A/20058: Polycomb-Associated Non-Coding RNAs.
MA445498 - JP 2018138019-A/17424: Polycomb-Associated Non-Coding RNAs.
MA568318 - JP 2018138019-A/140244: Polycomb-Associated Non-Coding RNAs.
MA568315 - JP 2018138019-A/140241: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein P19883 (Reactome details) participates in the following event(s):

R-HSA-2473184 Follistatin (FST) binds Activin
R-HSA-2473224 Antagonism of Activin by Follistatin
R-HSA-1502540 Signaling by Activin
R-HSA-9006936 Signaling by TGF-beta family members
R-HSA-162582 Signal Transduction

-  Other Names for This Gene
  Alternate Gene Symbols: B5BU94, ENST00000256759.1, ENST00000256759.2, ENST00000256759.3, ENST00000256759.4, ENST00000256759.5, ENST00000256759.6, ENST00000256759.7, FST , FST_HUMAN, NM_013409, P19883, Q9BTH0, uc317fwf.1, uc317fwf.2
UCSC ID: ENST00000256759.8_11
RefSeq Accession: NM_013409.3
Protein: P19883 (aka FST_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.