Human Gene FUS (ENST00000254108.12_8) from GENCODE V47lift37
  Description: FUS RNA binding protein, transcript variant 1 (from RefSeq NM_004960.4)
Gencode Transcript: ENST00000254108.12_8
Gencode Gene: ENSG00000089280.20_9
Transcript (Including UTRs)
   Position: hg19 chr16:31,191,460-31,202,926 Size: 11,467 Total Exon Count: 15 Strand: +
Coding Region
   Position: hg19 chr16:31,191,536-31,202,759 Size: 11,224 Coding Exon Count: 15 

Page IndexSequence and LinksPrimersMalaCardsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesGeneReviewsModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr16:31,191,460-31,202,926)mRNA (may differ from genome)Protein (526 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedUniProtKB
WikipediaBioGrid CRISPR DB

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: FUS
Diseases sorted by gene-association score: tremor, hereditary essential, 4* (1330), amyotrophic lateral sclerosis 6, with or without frontotemporal dementia* (1239), myxoid liposarcoma* (297), juvenile amyotrophic lateral sclerosis* (212), myxofibrosarcoma* (202), amyotrophic lateral sclerosis 1* (105), fus-related amyotrophic lateral sclerosis* (100), liposarcoma (69), fibrous histiocytoma (31), lateral sclerosis (31), tremor (19), histiocytoma (17), abnormal retinal correspondence (16), frontotemporal dementia and/or amyotrophic lateral sclerosis 1* (15), dementia (12), amyotrophic lateral sclerosis 18 (11), mixed liposarcoma (11), chondroid lipoma (11), binocular vision disease (11), anal carcinoma in situ (11), essential tremor (9), ewing sarcoma (9), expressive language disorder (9), lipomatosis, multiple (8), sarcoma (8), lethal congenital contracture syndrome 1 (7), connective tissue cancer (7), spondylolysis (7), locked-in syndrome (7), clear cell sarcoma (7), sclerosing liposarcoma (6), chondrosarcoma, extraskeletal myxoid (6), extraosseous chondrosarcoma (6), amyotrophic lateral sclerosis type 14 (6), juxtacortical chondroma (6), basal ganglia disease (6), atypical lipomatous tumor (6), amyotrophic lateral sclerosis 21 (6), amyotrophic lateral sclerosis 11 (6), extraskeletal ewing sarcoma (5), amyotrophic lateral sclerosis type 10 (5), ideomotor apraxia (4), amyotrophic lateral sclerosis 9 (4), anterior horn cell disease (4), amyotrophic lateral sclerosis 7 (4), dementia, frontotemporal (4), spinocerebellar ataxia 31 (3), nominal aphasia (3), motor neuron disease (3), nervous system disease (1)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 175.41 RPKM in Ovary
Total median expression: 4462.74 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -27.7076-0.364 Picture PostScript Text
3' UTR -28.10167-0.168 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR012677 - Nucleotide-bd_a/b_plait
IPR000504 - RRM_dom
IPR001876 - Znf_RanBP2

Pfam Domains:
PF00076 - RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
PF00641 - Zn-finger in Ran binding protein and others

SCOP Domains:
54928 - RNA-binding domain, RBD
90209 - Ran binding protein zinc finger-like

ModBase Predicted Comparative 3D Structure on Q6IBQ5
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0030331 estrogen receptor binding
GO:0031489 myosin V binding
GO:0035255 ionotropic glutamate receptor binding
GO:0046872 metal ion binding
GO:0046965 retinoid X receptor binding
GO:0046966 thyroid hormone receptor binding

Biological Process:
GO:0006355 regulation of transcription, DNA-templated
GO:0071277 cellular response to calcium ion

Cellular Component:
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005844 polysome
GO:0030425 dendrite
GO:0043025 neuronal cell body
GO:0043197 dendritic spine
GO:0043204 perikaryon
GO:0044327 dendritic spine head
GO:0048471 perinuclear region of cytoplasm


-  Descriptions from all associated GenBank mRNAs
  JA482084 - Sequence 67 from Patent WO2011072091.
JA482085 - Sequence 68 from Patent WO2011072091.
JA482086 - Sequence 69 from Patent WO2011072091.
JA482087 - Sequence 70 from Patent WO2011072091.
JE980376 - Sequence 67 from Patent EP2862929.
JE980377 - Sequence 68 from Patent EP2862929.
JE980378 - Sequence 69 from Patent EP2862929.
JE980379 - Sequence 70 from Patent EP2862929.
LF384300 - JP 2014500723-A/191803: Polycomb-Associated Non-Coding RNAs.
LF213744 - JP 2014500723-A/21247: Polycomb-Associated Non-Coding RNAs.
S62138 - TLS/CHOP=hybrid gene {translocation breakpoint} [human, myxoid liposarcomas cells, mRNA Mutant, 1682 nt].
AK130774 - Homo sapiens cDNA FLJ27264 fis, clone TMS00177, highly similar to RNA-binding protein FUS.
S62140 - TLS=translocated in liposarcoma [human, mRNA, 1824 nt].
AK098774 - Homo sapiens cDNA FLJ25908 fis, clone CBR04634, highly similar to RNA-BINDING PROTEIN FUS/TLS.
AK290936 - Homo sapiens cDNA FLJ78268 complete cds, highly similar to Homo sapiens fusion (involved in t(12;16) in malignant liposarcoma), transcript variant 1, mRNA.
AK299129 - Homo sapiens cDNA FLJ58049 complete cds, highly similar to RNA-binding protein FUS.
BC000402 - Homo sapiens fusion (involved in t(12;16) in malignant liposarcoma), mRNA (cDNA clone MGC:8537 IMAGE:2822692), complete cds.
AB208902 - Homo sapiens mRNA for fusion (involved in t(12;16) in malignant liposarcoma) isoform a variant protein.
X71428 - Homo sapiens mRNA for FUS gycline rich protein.
X71427 - Homo sapiens mRNA for FUS-CHOP protein fusion.
BC026062 - Homo sapiens fusion (involved in t(12;16) in malignant liposarcoma), mRNA (cDNA clone MGC:16383 IMAGE:3937437), complete cds.
BC002459 - Homo sapiens fusion (involved in t(12;16) in malignant liposarcoma), mRNA (cDNA clone MGC:3068 IMAGE:3345294), complete cds.
U00942 - Human clone A9A2BR17 (CAC)n/(GTG)n repeat-containing mRNA.
KJ896835 - Synthetic construct Homo sapiens clone ccsbBroadEn_06229 FUS gene, encodes complete protein.
KR709909 - Synthetic construct Homo sapiens clone CCSBHm_00007688 FUS (FUS) mRNA, encodes complete protein.
AB527797 - Synthetic construct DNA, clone: pF1KB5906, Homo sapiens FUS gene for RNA-binding protein FUS, without stop codon, in Flexi system.
U36561 - Human fus-like protein mRNA, partial cds.
DQ894882 - Synthetic construct Homo sapiens clone IMAGE:100009342; FLH184223.01L; RZPDo839D07143D fusion (involved in t(12;16) in malignant liposarcoma) (FUS) gene, encodes complete protein.
BT007131 - Homo sapiens fusion, derived from t(12;16) malignant liposarcoma mRNA, complete cds.
DQ891705 - Synthetic construct clone IMAGE:100004335; FLH184227.01X; RZPDo839D07144D fusion (involved in t(12;16) in malignant liposarcoma) (FUS) gene, encodes complete protein.
CR456747 - Homo sapiens full open reading frame cDNA clone RZPDo834F0214D for gene FUS, fusion (involved in t(12;16) in malignant liposarcoma); complete cds, incl. stopcodon.
MA619877 - JP 2018138019-A/191803: Polycomb-Associated Non-Coding RNAs.
MA449321 - JP 2018138019-A/21247: Polycomb-Associated Non-Coding RNAs.
AK301110 - Homo sapiens cDNA FLJ57206 complete cds, moderately similar to RNA-binding protein FUS.
AJ301612 - Homo sapiens partial mRNA for FUS/CHOP chimaeric fusion protein (type 9 transcript variant).
LF370047 - JP 2014500723-A/177550: Polycomb-Associated Non-Coding RNAs.
MA605624 - JP 2018138019-A/177550: Polycomb-Associated Non-Coding RNAs.
S75763 - FUS...CHOP [human, myxoid liposarcoma specimens, mRNA Partial Mutant, 3 genes, 377 nt].
S75762 - FUS...CHOP [human, myxoid liposarcoma specimens, mRNA Partial Mutant, 3 genes, 652 nt].
GU933437 - Homo sapiens DDIT3/FUS translocation breakpoint region mRNA sequence.
JD021251 - Sequence 2275 from Patent EP1572962.
LF370049 - JP 2014500723-A/177552: Polycomb-Associated Non-Coding RNAs.
DQ598296 - Homo sapiens piRNA piR-36362, complete sequence.
LF370050 - JP 2014500723-A/177553: Polycomb-Associated Non-Coding RNAs.
JC506674 - Sequence 42 from Patent EP2733220.
JC506688 - Sequence 56 from Patent EP2733220.
JC737786 - Sequence 42 from Patent WO2014075939.
JC737800 - Sequence 56 from Patent WO2014075939.
JD029860 - Sequence 10884 from Patent EP1572962.
S71805 - TLS/FUS...ERG {translocation} [human, myeloid leukemia patient, peripheral blood, bone marrow cells, mRNA Partial Mutant, 3 genes, 99 nt].
AJ549095 - Homo sapiens t(7;16)(q33;p11) translocation breakpoint mRNA for partial chimaeric BBF2H7/FUS protein, isolate patient 1, long variant.
AJ549096 - Homo sapiens t(7;16)(q33;p11) translocation breakpoint mRNA for partial chimaeric BBF2H7/FUS protein, isolate patient 1, short variant.
LF370060 - JP 2014500723-A/177563: Polycomb-Associated Non-Coding RNAs.
LF370061 - JP 2014500723-A/177564: Polycomb-Associated Non-Coding RNAs.
BC051293 - Homo sapiens fusion (involved in t(12;16) in malignant liposarcoma), mRNA (cDNA clone IMAGE:3609275), with apparent retained intron.
LF370062 - JP 2014500723-A/177565: Polycomb-Associated Non-Coding RNAs.
LF370063 - JP 2014500723-A/177566: Polycomb-Associated Non-Coding RNAs.
AJ301611 - Homo sapiens partial mRNA for FUS/CHOP chimaeric fusion protein (type 8 transcript variant).
LF370064 - JP 2014500723-A/177567: Polycomb-Associated Non-Coding RNAs.
LF370066 - JP 2014500723-A/177569: Polycomb-Associated Non-Coding RNAs.
LF370067 - JP 2014500723-A/177570: Polycomb-Associated Non-Coding RNAs.
JD341191 - Sequence 322215 from Patent EP1572962.
JD396433 - Sequence 377457 from Patent EP1572962.
LF370068 - JP 2014500723-A/177571: Polycomb-Associated Non-Coding RNAs.
MA605626 - JP 2018138019-A/177552: Polycomb-Associated Non-Coding RNAs.
MA605627 - JP 2018138019-A/177553: Polycomb-Associated Non-Coding RNAs.
MA605637 - JP 2018138019-A/177563: Polycomb-Associated Non-Coding RNAs.
MA605638 - JP 2018138019-A/177564: Polycomb-Associated Non-Coding RNAs.
MA605639 - JP 2018138019-A/177565: Polycomb-Associated Non-Coding RNAs.
MA605640 - JP 2018138019-A/177566: Polycomb-Associated Non-Coding RNAs.
MA605641 - JP 2018138019-A/177567: Polycomb-Associated Non-Coding RNAs.
MA605643 - JP 2018138019-A/177569: Polycomb-Associated Non-Coding RNAs.
MA605644 - JP 2018138019-A/177570: Polycomb-Associated Non-Coding RNAs.
MA605645 - JP 2018138019-A/177571: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000254108.1, ENST00000254108.10, ENST00000254108.11, ENST00000254108.2, ENST00000254108.3, ENST00000254108.4, ENST00000254108.5, ENST00000254108.6, ENST00000254108.7, ENST00000254108.8, ENST00000254108.9, FUS , hCG_21147 , NM_004960, Q6IBQ5, Q6IBQ5_HUMAN, uc317fng.1, uc317fng.2
UCSC ID: ENST00000254108.12_8
RefSeq Accession: NM_004960.4
Protein: Q6IBQ5

-  GeneReviews for This Gene
  GeneReviews article(s) related to gene FUS:
als-overview (Amyotrophic Lateral Sclerosis Overview)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.