Human Gene FUT4 (ENST00000358752.4_3) from GENCODE V47lift37
  Description: fucosyltransferase 4 (from RefSeq NM_002033.4)
Gencode Transcript: ENST00000358752.4_3
Gencode Gene: ENSG00000196371.4_7
Transcript (Including UTRs)
   Position: hg19 chr11:94,277,087-94,283,061 Size: 5,975 Total Exon Count: 1 Strand: +
Coding Region
   Position: hg19 chr11:94,277,300-94,278,892 Size: 1,593 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr11:94,277,087-94,283,061)mRNA (may differ from genome)Protein (530 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
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-  Comments and Description Text from UniProtKB
  ID: FUT4_HUMAN
DESCRIPTION: RecName: Full=Alpha-(1,3)-fucosyltransferase; EC=2.4.1.-; AltName: Full=ELAM-1 ligand fucosyltransferase; AltName: Full=Fucosyltransferase 4; AltName: Full=Fucosyltransferase IV; Short=Fuc-TIV; Short=FucT-IV; AltName: Full=Galactoside 3-L-fucosyltransferase;
FUNCTION: May catalyze alpha-1,3 glycosidic linkages involved in the expression of Lewis X/SSEA-1 and VIM-2 antigens.
PATHWAY: Protein modification; protein glycosylation.
SUBCELLULAR LOCATION: Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Note=Membrane-bound form in trans cisternae of Golgi.
SIMILARITY: Belongs to the glycosyltransferase 10 family.
CAUTION: It is uncertain whether Met-1 or Met-126 is the initiator.
SEQUENCE CAUTION: Sequence=AAB20349.1; Type=Frameshift; Positions=114;
WEB RESOURCE: Name=GGDB; Note=GlycoGene database; URL="http://riodb.ibase.aist.go.jp/rcmg/ggdb/Homolog?cat=symbol&symbol=FUT4";
WEB RESOURCE: Name=Functional Glycomics Gateway - GTase; Note=Fucosyltransferase 4; URL="http://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_hum_601";

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: FUT4
Diseases sorted by gene-association score: colon adenocarcinoma (4), liver lymphoma (3), sternum cancer (2), malignant ovarian cyst (2), adult xanthogranuloma (2), hodgkin's lymphoma, lymphocytic depletion (2), mixed germ cell cancer (2), mediastinal malignant lymphoma (2), mediastinal gray zone lymphoma (2), granulomatous gastritis (2), germ cell and embryonal cancer (2), nodular hidradenoma (1), malignant biphasic mesothelioma (1), malignant epithelial mesothelioma (1), testicular infarct (1), epidural neoplasm (1), colorectal cancer (1), infiltrative basal cell carcinoma (1), chorioangioma (1), mucinous tubular and spindle renal cell carcinoma (1), urethral diverticulum (1), gamma heavy chain disease (1), aleukemic leukemia cutis (1), hemangioma of intra-abdominal structure (1), chronic nk-cell lymphocytosis (1), leukemia, acute myeloid (1), secretory meningioma (1), reticulohistiocytic granuloma (1), brain germinoma (1), leber congenital amaurosis (1), cribriform carcinoma (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
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+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -88.10213-0.414 Picture PostScript Text
3' UTR -1157.404169-0.278 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001503 - Glyco_trans_10

Pfam Domains:
PF00852 - Glycosyltransferase family 10 (fucosyltransferase) C-term
PF17039 - Fucosyltransferase, N-terminal

SCOP Domains:
53756 - UDP-Glycosyltransferase/glycogen phosphorylase

ModBase Predicted Comparative 3D Structure on P22083
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0008417 fucosyltransferase activity
GO:0016740 transferase activity
GO:0016757 transferase activity, transferring glycosyl groups
GO:0046920 alpha-(1->3)-fucosyltransferase activity

Biological Process:
GO:0005975 carbohydrate metabolic process
GO:0006486 protein glycosylation
GO:0036065 fucosylation
GO:0042355 L-fucose catabolic process

Cellular Component:
GO:0000139 Golgi membrane
GO:0005794 Golgi apparatus
GO:0009986 cell surface
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0032580 Golgi cisterna membrane
GO:0071944 cell periphery


-  Descriptions from all associated GenBank mRNAs
  AK293616 - Homo sapiens cDNA FLJ57260 complete cds, highly similar to Piwi-like protein 4.
M58597 - Human ELAM-1 ligand fucosyltransferase (ELFT) mRNA, complete cds.
BC136373 - Homo sapiens fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific), mRNA (cDNA clone MGC:167983 IMAGE:9020360), complete cds.
BC136374 - Homo sapiens fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific), mRNA (cDNA clone MGC:167984 IMAGE:9020361), complete cds.
JD507004 - Sequence 488028 from Patent EP1572962.
JD394757 - Sequence 375781 from Patent EP1572962.
A23701 - H.sapiens alpha(1-3)fucosyltransferase.
M58596 - Human ELAM-1 ligand fucosyltransferase (ELFT) mRNA, complete cds.
CR749642 - Homo sapiens mRNA; cDNA DKFZp686P01248 (from clone DKFZp686P01248).
JD432290 - Sequence 413314 from Patent EP1572962.
AF305083 - Homo sapiens alpha(1,3)-fucosyltransferase IV (FUTIV) gene, 3' UTR.
JD481289 - Sequence 462313 from Patent EP1572962.
JD471866 - Sequence 452890 from Patent EP1572962.
JD350330 - Sequence 331354 from Patent EP1572962.
JD535664 - Sequence 516688 from Patent EP1572962.
JD500294 - Sequence 481318 from Patent EP1572962.
JD205180 - Sequence 186204 from Patent EP1572962.
JD468977 - Sequence 450001 from Patent EP1572962.
JD354974 - Sequence 335998 from Patent EP1572962.
JD352797 - Sequence 333821 from Patent EP1572962.
JD102622 - Sequence 83646 from Patent EP1572962.
JD436852 - Sequence 417876 from Patent EP1572962.
JD562600 - Sequence 543624 from Patent EP1572962.
DQ601090 - Homo sapiens piRNA piR-39156, complete sequence.

-  Biochemical and Signaling Pathways
  BioCarta from NCI Cancer Genome Anatomy Project
h_aMANpathway - Steps in the Glycosylation of Mammalian N-linked Oligosaccarides

-  Other Names for This Gene
  Alternate Gene Symbols: B2RMS0, ELFT , ENST00000358752.1, ENST00000358752.2, ENST00000358752.3, FCT3A, FUT4 , FUT4_HUMAN, NM_002033, P22083, uc318asm.1, uc318asm.2
UCSC ID: ENST00000358752.4_3
RefSeq Accession: NM_002033.4
Protein: P22083 (aka FUT4_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.