ID:FXYD6_HUMAN DESCRIPTION: RecName: Full=FXYD domain-containing ion transport regulator 6; AltName: Full=Phosphohippolin; Flags: Precursor; SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein (Potential). DISEASE: Genetic variations in FXYD6 are associated with susceptibility to schizophrenia type 2 (SCZD2) [MIM:603342]. A complex, multifactorial psychotic disorder or group of disorders characterized by disturbances in the form and content of thought (e.g. delusions, hallucinations), in mood (e.g. inappropriate affect), in sense of self and relationship to the external world (e.g. loss of ego boundaries, withdrawal), and in behavior (e.g bizarre or apparently purposeless behavior). Although it affects emotions, it is distinguished from mood disorders in which such disturbances are primary. Similarly, there may be mild impairment of cognitive function, and it is distinguished from the dementias in which disturbed cognitive function is considered primary. Some patients manifest schizophrenic as well as bipolar disorder symptoms and are often given the diagnosis of schizoaffective disorder. SIMILARITY: Belongs to the FXYD family. SEQUENCE CAUTION: Sequence=AAQ89335.1; Type=Frameshift; Positions=93;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9H0Q3
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006811 ion transport GO:0008150 biological_process GO:0034220 ion transmembrane transport GO:2000649 regulation of sodium ion transmembrane transporter activity
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
