ID:FZD8_HUMAN DESCRIPTION: RecName: Full=Frizzled-8; Short=Fz-8; Short=hFz8; Flags: Precursor; FUNCTION: Receptor for Wnt proteins. Component of the Wnt-Fzd- LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome- sized signalosomes. The beta-catenin canonical signaling pathway leads to the activation of disheveled proteins, inhibition of GSK- 3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Coreceptor along with RYK of Wnt proteins, such as WNT1. SUBUNIT: Component of a Wnt-signaling complex that contains a WNT protein, a FZD protein and LRP5 or LRP6. Interacts directly with LRP5 or LRP6; the interaction is promoted by Wnt-binding and signaling and inhibited by DKK1. Interacts with GPOC, RSPO1 and RSPO3 (By similarity). INTERACTION: P98086:C1qa (xeno); NbExp=3; IntAct=EBI-6254212, EBI-6171723; P56704:WNT3A; NbExp=2; IntAct=EBI-6254212, EBI-6173037; SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. Golgi apparatus (By similarity). Cell membrane; Multi-pass membrane protein (By similarity). Note=Colocalizes with GOPC at the Golgi apparatus (By similarity). TISSUE SPECIFICITY: Most abundant in fetal kidney, followed by brain and lung. In adult tissues, expressed in kidney, heart, pancreas and skeletal muscle. DOMAIN: The PDZ-binding motif mediates interaction with GOPC (By similarity). DOMAIN: Lys-Thr-X-X-X-Trp motif interacts with the PDZ doman of Dvl (Disheveled) family members and is involved in the activation of the Wnt/beta-catenin signaling pathway (By similarity). DOMAIN: The FZ domain is involved in binding with Wnt ligands (By similarity). PTM: Ubiquitinated by ZNRF3, leading to its degradation by the proteasome. SIMILARITY: Belongs to the G-protein coupled receptor Fz/Smo family. SIMILARITY: Contains 1 FZ (frizzled) domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9H461
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
