Human Gene G3BP1 (ENST00000356245.8_4) from GENCODE V47lift37
  Description: G3BP stress granule assembly factor 1, transcript variant 2 (from RefSeq NM_198395.2)
Gencode Transcript: ENST00000356245.8_4
Gencode Gene: ENSG00000145907.16_17
Transcript (Including UTRs)
   Position: hg19 chr5:151,151,515-151,192,346 Size: 40,832 Total Exon Count: 12 Strand: +
Coding Region
   Position: hg19 chr5:151,166,182-151,183,652 Size: 17,471 Coding Exon Count: 11 

Page IndexSequence and LinksPrimersCTDGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr5:151,151,515-151,192,346)mRNA (may differ from genome)Protein (466 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMGIOMIMPubMedUniProtKBWikipedia
BioGrid CRISPR DB

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 25.83 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 519.26 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -39.30132-0.298 Picture PostScript Text
3' UTR -2304.008694-0.265 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR002075 - NTF2
IPR018222 - Nuclear_transport_factor_2_euk
IPR012677 - Nucleotide-bd_a/b_plait
IPR000504 - RRM_dom

Pfam Domains:
PF00076 - RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
PF02136 - Nuclear transport factor 2 (NTF2) domain

SCOP Domains:
54427 - NTF2-like
54928 - RNA-binding domain, RBD

ModBase Predicted Comparative 3D Structure on Q5U0Q1
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0003729 mRNA binding

Biological Process:
GO:0090090 negative regulation of canonical Wnt signaling pathway

Cellular Component:
GO:0005829 cytosol
GO:0010494 cytoplasmic stress granule


-  Descriptions from all associated GenBank mRNAs
  BX648012 - Homo sapiens mRNA; cDNA DKFZp686L1159 (from clone DKFZp686L1159).
LP895522 - Sequence 386 from Patent EP3253886.
AK303580 - Homo sapiens cDNA FLJ51772 complete cds, highly similar to Ras-GTPase-activating protein-binding protein 1 (EC 3.6.1.-).
AK311635 - Homo sapiens cDNA, FLJ18677.
AK309172 - Homo sapiens cDNA, FLJ99213.
AK312572 - Homo sapiens cDNA, FLJ92947, Homo sapiens Ras-GTPase-activating protein SH3-domain-bindingprotein (G3BP), mRNA.
BC006997 - Homo sapiens GTPase activating protein (SH3 domain) binding protein 1, mRNA (cDNA clone MGC:12272 IMAGE:3950738), complete cds.
AK300098 - Homo sapiens cDNA FLJ50206 complete cds, highly similar to Ras-GTPase-activating protein-binding protein 1 (EC 3.6.1.-).
AK222606 - Homo sapiens mRNA for Ras-GTPase-activating protein SH3-domain-binding protein variant, clone: CAS05140.
BX647869 - Homo sapiens mRNA; cDNA DKFZp313K0921 (from clone DKFZp313K0921).
AK130003 - Homo sapiens cDNA FLJ26493 fis, clone KDN06317, highly similar to Ras-GTPase-activating protein binding protein 1.
U32519 - Human GAP SH3 binding protein mRNA, complete cds.
BC108278 - Homo sapiens GTPase activating protein (SH3 domain) binding protein 1, mRNA (cDNA clone MGC:111040 IMAGE:6051310), complete cds.
JD152555 - Sequence 133579 from Patent EP1572962.
JD427603 - Sequence 408627 from Patent EP1572962.
CU675483 - Synthetic construct Homo sapiens gateway clone IMAGE:100019534 5' read G3BP1 mRNA.
BT019384 - Homo sapiens Ras-GTPase-activating protein SH3-domain-binding protein mRNA, complete cds.
CR536535 - Homo sapiens full open reading frame cDNA clone RZPDo834G0320D for gene G3BP, Ras-GTPase-activating protein SH3-domain-binding protein; complete cds, incl. stopcodon.
DQ893058 - Synthetic construct clone IMAGE:100005688; FLH193150.01X; RZPDo839D0378D Ras-GTPase-activating protein SH3-domain-binding protein (G3BP) gene, encodes complete protein.
DQ896308 - Synthetic construct Homo sapiens clone IMAGE:100010768; FLH193146.01L; RZPDo839D0368D Ras-GTPase-activating protein SH3-domain-binding protein (G3BP) gene, encodes complete protein.
KJ892936 - Synthetic construct Homo sapiens clone ccsbBroadEn_02330 G3BP1 gene, encodes complete protein.
JD025970 - Sequence 6994 from Patent EP1572962.
JD027792 - Sequence 8816 from Patent EP1572962.
DL491584 - Novel nucleic acids.
JD314132 - Sequence 295156 from Patent EP1572962.
AK128316 - Homo sapiens cDNA FLJ46457 fis, clone THYMU3020856.
DQ573376 - Homo sapiens piRNA piR-41488, complete sequence.

-  Other Names for This Gene
  Alternate Gene Symbols: DKFZp686L1159 , ENST00000356245.1, ENST00000356245.2, ENST00000356245.3, ENST00000356245.4, ENST00000356245.5, ENST00000356245.6, ENST00000356245.7, G3BP , hCG_39146 , NM_198395, Q5U0Q1, Q5U0Q1_HUMAN, uc317zly.1, uc317zly.2
UCSC ID: ENST00000356245.8_4
RefSeq Accession: NM_005754.3
Protein: Q5U0Q1

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.