ID:G6PC2_HUMAN DESCRIPTION: RecName: Full=Glucose-6-phosphatase 2; Short=G-6-Pase 2; Short=G6Pase 2; EC=3.1.3.9; AltName: Full=Islet-specific glucose-6-phosphatase catalytic subunit-related protein; FUNCTION: May hydrolyze glucose-6-phosphate to glucose in the endoplasmic reticulum. May be responsible for glucose production through glycogenolysis and gluconeogenesis (By similarity). CATALYTIC ACTIVITY: D-glucose 6-phosphate + H(2)O = D-glucose + phosphate. BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=0.45 mM for glucose-6-phosphate (at pH 6.5); PATHWAY: Carbohydrate biosynthesis; gluconeogenesis. SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Multi-pass membrane protein. TISSUE SPECIFICITY: Specifically expressed in pancreas and also detected to a lower extent in testis. Expressed by most islet cells in the pancreas (at protein level). PTM: N-glycosylated; the non-glycosylated form is more unstable and is degraded through the proteasome. POLYMORPHISM: Genetic variations in G6PC2 define the fasting plasma glucose levels quantitative trait locus 1 (FGQTL1) [MIM:612108]. The normal fasting plasma glucose level in the plasma is defined as less than 100 mg per deciliter (5.55 mmol per liter). Higher fasting plasma glucose levels predict type 2 diabetes in young adults and increases the risk of mortality. SIMILARITY: Belongs to the glucose-6-phosphatase family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9NQR9
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
