ID:GALA_HUMAN DESCRIPTION: RecName: Full=Galanin peptides; Contains: RecName: Full=Galanin; Contains: RecName: Full=Galanin message-associated peptide; Short=GMAP; Flags: Precursor; FUNCTION: Contracts smooth muscle of the gastrointestinal and genitourinary tract, regulates growth hormone release, modulates insulin release, and may be involved in the control of adrenal secretion. SUBCELLULAR LOCATION: Secreted. SIMILARITY: Belongs to the galanin family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P22466
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0004966 galanin receptor activity GO:0005179 hormone activity GO:0005184 neuropeptide hormone activity GO:0005515 protein binding GO:0031764 type 1 galanin receptor binding GO:0031765 type 2 galanin receptor binding GO:0031766 type 3 galanin receptor binding
Biological Process: GO:0006954 inflammatory response GO:0007186 G-protein coupled receptor signaling pathway GO:0007218 neuropeptide signaling pathway GO:0007399 nervous system development GO:0007631 feeding behavior GO:0008285 negative regulation of cell proliferation GO:0010469 regulation of receptor activity GO:0010737 protein kinase A signaling GO:0019933 cAMP-mediated signaling GO:0030073 insulin secretion GO:0031943 regulation of glucocorticoid metabolic process GO:0032868 response to insulin GO:0035902 response to immobilization stress GO:0042493 response to drug GO:0043065 positive regulation of apoptotic process GO:0043627 response to estrogen GO:0045944 positive regulation of transcription from RNA polymerase II promoter GO:0050672 negative regulation of lymphocyte proliferation GO:0051464 positive regulation of cortisol secretion GO:0051795 positive regulation of catagen GO:1902608 positive regulation of large conductance calcium-activated potassium channel activity GO:1902891 negative regulation of root hair elongation
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
