Human Gene GANAB (ENST00000356638.8_10) from GENCODE V47lift37

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Description: glucosidase II alpha subunit, transcript variant 2 (from RefSeq NM_198334.3)
Gencode Transcript: ENST00000356638.8_10
Gencode Gene: ENSG00000089597.18_14
Transcript (Including UTRs)
Position: hg19 chr11:62,392,301-62,414,085 Size: 21,785 Total Exon Count: 24 Strand: -
Coding Region
Position: hg19 chr11:62,393,287-62,414,071 Size: 20,785 Coding Exon Count: 24

Page Index	Sequence and Links	Primers	MalaCards	CTD	Gene Alleles
RNA-Seq Expression	Microarray Expression	RNA Structure	Other Species	mRNA Descriptions	Pathways
Other Names	GeneReviews	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr11:62,392,301-62,414,085)			mRNA (may differ from genome)		Protein (944 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
HGNC	Malacards	MGI	OMIM	PubMed	UniProtKB
Wikipedia	BioGrid CRISPR DB

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

MalaCards Disease Associations


	MalaCards Gene Search: GANAB Diseases sorted by gene-association score: polycystic kidney disease 3* (1230), polycyctic kidney disease 3* (100), polycystic liver disease (9), polycystic kidney disease (9), glycogen storage disease ii (6) * = Manually curated disease association

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene C029497 2,3-bis(3'-hydroxybenzyl)butyrolactone D001151 Arsenic D001564 Benzo(a)pyrene D002794 Choline D003375 Coumestrol D004997 Ethinyl Estradiol D005492 Folic Acid D006830 Hydralazine D006861 Hydrogen Peroxide D008094 Lithium more ... click here to view the complete list

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 141.87 RPKM in Cells - Cultured fibroblasts Total median expression: 3040.51 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
3' UTR	-337.50	986	-0.342	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	Genome Browser	Genome Browser
Gene Details	Gene Details		Gene Details	Gene Details	Gene Details
Gene Sorter	Gene Sorter		Gene Sorter	Gene Sorter	Gene Sorter
	RGD	Ensembl		WormBase	SGD
				Protein Sequence	Protein Sequence
				Alignment	Alignment

Descriptions from all associated GenBank mRNAs


	LF211234 - JP 2014500723-A/18737: Polycomb-Associated Non-Coding RNAs. EU794613 - Homo sapiens epididymis secretory sperm binding protein Li 164nA (HEL-S-164nA) mRNA, complete cds. D42041 - Homo sapiens KIAA0088 mRNA, partial cds. AK026567 - Homo sapiens cDNA: FLJ22914 fis, clone KAT06317. BC005405 - Homo sapiens glucosidase, alpha; neutral AB, mRNA (cDNA clone IMAGE:3458604), partial cds. AK026548 - Homo sapiens cDNA: FLJ22895 fis, clone KAT04940. BC065266 - Homo sapiens glucosidase, alpha; neutral AB, mRNA (cDNA clone MGC:70558 IMAGE:6155944), complete cds. BC017433 - Homo sapiens glucosidase, alpha; neutral AB, mRNA (cDNA clone IMAGE:2959208), partial cds. BC017435 - Homo sapiens glucosidase, alpha; neutral AB, mRNA (cDNA clone IMAGE:2959208), partial cds. LF344813 - JP 2014500723-A/152316: Polycomb-Associated Non-Coding RNAs. BC034439 - Homo sapiens glucosidase, alpha; neutral AB, mRNA (cDNA clone IMAGE:4538370). LF344812 - JP 2014500723-A/152315: Polycomb-Associated Non-Coding RNAs. AK026997 - Homo sapiens cDNA: FLJ23344 fis, clone HEP13643. LF344811 - JP 2014500723-A/152314: Polycomb-Associated Non-Coding RNAs. LF344810 - JP 2014500723-A/152313: Polycomb-Associated Non-Coding RNAs. AK295899 - Homo sapiens cDNA FLJ61290 complete cds, highly similar to Neutral alpha-glucosidase AB precursor. LF344808 - JP 2014500723-A/152311: Polycomb-Associated Non-Coding RNAs. AK302752 - Homo sapiens cDNA FLJ59643 complete cds, highly similar to Neutral alpha-glucosidase AB precursor. AK299819 - Homo sapiens cDNA FLJ54057 complete cds, highly similar to Neutral alpha-glucosidase AB precursor. AK295806 - Homo sapiens cDNA FLJ54035 complete cds, highly similar to Neutral alpha-glucosidase AB precursor. AJ000332 - Homo sapiens mRNA for glucosidase II. AK314370 - Homo sapiens cDNA, FLJ95138. AF144074 - Homo sapiens glucosidase II alpha subunit mRNA, complete cds. AB383744 - Synthetic construct DNA, clone: pF1KSDA0088, Homo sapiens GANAB gene for neutral alpha-glucosidase AB precursor, complete cds, without stop codon, in Flexi system. KJ902298 - Synthetic construct Homo sapiens clone ccsbBroadEn_11692 GANAB gene, encodes complete protein. LF344805 - JP 2014500723-A/152308: Polycomb-Associated Non-Coding RNAs. LF344804 - JP 2014500723-A/152307: Polycomb-Associated Non-Coding RNAs. LF344802 - JP 2014500723-A/152305: Polycomb-Associated Non-Coding RNAs. LF344801 - JP 2014500723-A/152304: Polycomb-Associated Non-Coding RNAs. JD024353 - Sequence 5377 from Patent EP1572962. JD031093 - Sequence 12117 from Patent EP1572962. LF344799 - JP 2014500723-A/152302: Polycomb-Associated Non-Coding RNAs. LF344798 - JP 2014500723-A/152301: Polycomb-Associated Non-Coding RNAs. LF344797 - JP 2014500723-A/152300: Polycomb-Associated Non-Coding RNAs. LF344796 - JP 2014500723-A/152299: Polycomb-Associated Non-Coding RNAs. LF344794 - JP 2014500723-A/152297: Polycomb-Associated Non-Coding RNAs. LF344787 - JP 2014500723-A/152290: Polycomb-Associated Non-Coding RNAs. LF344785 - JP 2014500723-A/152288: Polycomb-Associated Non-Coding RNAs. LF344784 - JP 2014500723-A/152287: Polycomb-Associated Non-Coding RNAs. LF344783 - JP 2014500723-A/152286: Polycomb-Associated Non-Coding RNAs. LF344780 - JP 2014500723-A/152283: Polycomb-Associated Non-Coding RNAs. MA580390 - JP 2018138019-A/152316: Polycomb-Associated Non-Coding RNAs. MA580389 - JP 2018138019-A/152315: Polycomb-Associated Non-Coding RNAs. MA580388 - JP 2018138019-A/152314: Polycomb-Associated Non-Coding RNAs. MA580387 - JP 2018138019-A/152313: Polycomb-Associated Non-Coding RNAs. MA580385 - JP 2018138019-A/152311: Polycomb-Associated Non-Coding RNAs. MA580382 - JP 2018138019-A/152308: Polycomb-Associated Non-Coding RNAs. MA580381 - JP 2018138019-A/152307: Polycomb-Associated Non-Coding RNAs. MA580379 - JP 2018138019-A/152305: Polycomb-Associated Non-Coding RNAs. MA580378 - JP 2018138019-A/152304: Polycomb-Associated Non-Coding RNAs. MA580376 - JP 2018138019-A/152302: Polycomb-Associated Non-Coding RNAs. MA580375 - JP 2018138019-A/152301: Polycomb-Associated Non-Coding RNAs. MA580374 - JP 2018138019-A/152300: Polycomb-Associated Non-Coding RNAs. MA580373 - JP 2018138019-A/152299: Polycomb-Associated Non-Coding RNAs. MA580371 - JP 2018138019-A/152297: Polycomb-Associated Non-Coding RNAs. MA580364 - JP 2018138019-A/152290: Polycomb-Associated Non-Coding RNAs. MA580362 - JP 2018138019-A/152288: Polycomb-Associated Non-Coding RNAs. MA580361 - JP 2018138019-A/152287: Polycomb-Associated Non-Coding RNAs. MA580360 - JP 2018138019-A/152286: Polycomb-Associated Non-Coding RNAs. MA580357 - JP 2018138019-A/152283: Polycomb-Associated Non-Coding RNAs. MA446811 - JP 2018138019-A/18737: Polycomb-Associated Non-Coding RNAs.

Biochemical and Signaling Pathways


	BioCyc Knowledge Library PWY-7919 - protein N-glycosylation processing phase (mammalian) BioCarta from NCI Cancer Genome Anatomy Project h_eradPathway - ER¿associated degradation (ERAD) Pathway

Other Names for This Gene


	Alternate Gene Symbols: ENST00000356638.1, ENST00000356638.2, ENST00000356638.3, ENST00000356638.4, ENST00000356638.5, ENST00000356638.6, ENST00000356638.7, HEL-S-164nA , NM_198334, uc317zqn.1, uc317zqn.2, V9HWJ0, V9HWJ0_HUMAN UCSC ID: ENST00000356638.8_10 RefSeq Accession: NM_198334.3

GeneReviews for This Gene


	GeneReviews article(s) related to gene GANAB: pkd-ad (Polycystic Kidney Disease, Autosomal Dominant)

Gene Model Information


	Click here for a detailed description of the fields of the table above.

Methods, Credits, and Use Restrictions


	Click here for details on how this gene model was made and data restrictions if any.