Human Gene GAP43 (ENST00000305124.11_6) from GENCODE V47lift37
  Description: growth associated protein 43, transcript variant 2 (from RefSeq NM_002045.4)
Gencode Transcript: ENST00000305124.11_6
Gencode Gene: ENSG00000172020.13_8
Transcript (Including UTRs)
   Position: hg19 chr3:115,342,357-115,440,330 Size: 97,974 Total Exon Count: 3 Strand: +
Coding Region
   Position: hg19 chr3:115,342,537-115,439,729 Size: 97,193 Coding Exon Count: 3 

Page IndexSequence and LinksPrimersMalaCardsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr3:115,342,357-115,440,330)mRNA (may differ from genome)Protein (238 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCHuman Cortex Gene ExpressionMalacardsMGIOMIMPubMed
UniProtKBWikipediaBioGrid CRISPR DB

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: GAP43
Diseases sorted by gene-association score: developmental coordination disorder (15), myositis fibrosa (11), status epilepticus (8), pneumonic plague (8), pheochromocytoma (2), schizophrenia (1), amyotrophic lateral sclerosis 1 (1), dementia, frontotemporal (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 244.65 RPKM in Brain - Frontal Cortex (BA9)
Total median expression: 1435.82 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -29.64180-0.165 Picture PostScript Text
3' UTR -120.80601-0.201 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000048 - IQ_motif_EF-hand-BS
IPR001422 - Neuromodulin
IPR017454 - Neuromodulin_C
IPR018947 - Neuromodulin_gap-junction_N
IPR018243 - Neuromodulin_palmitoyl/P_site

Pfam Domains:
PF00612 - IQ calmodulin-binding motif
PF06614 - Neuromodulin
PF10580 - Gap junction protein N-terminal region

ModBase Predicted Comparative 3D Structure on Q5U058
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGDEnsembl   
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Biological Process:
GO:0040008 regulation of growth

Cellular Component:
GO:0005886 plasma membrane


-  Descriptions from all associated GenBank mRNAs
  AF279774 - Homo sapiens clone N4 NTera2D1 teratocarcinoma mRNA.
AK289699 - Homo sapiens cDNA FLJ75013 complete cds.
M25667 - Human neuronal growth protein 43 (GAP-43) mRNA, complete cds.
AK313658 - Homo sapiens cDNA, FLJ94238, Homo sapiens growth associated protein 43 (GAP43), mRNA.
BX648458 - Homo sapiens mRNA; cDNA DKFZp686C20269 (from clone DKFZp686C20269).
AK290100 - Homo sapiens cDNA FLJ78058 complete cds.
BC007936 - Homo sapiens growth associated protein 43, mRNA (cDNA clone MGC:14099 IMAGE:4126520), complete cds.
AK123311 - Homo sapiens cDNA FLJ41317 fis, clone BRAMY2043345, highly similar to NEUROMODULIN.
AM392759 - Synthetic construct Homo sapiens clone IMAGE:100002550 for hypothetical protein (GAP43 gene).
AM393509 - Synthetic construct Homo sapiens clone IMAGE:100002551 for hypothetical protein (GAP43 gene).
DQ893244 - Synthetic construct clone IMAGE:100005874; FLH195564.01X; RZPDo839D10152D growth associated protein 43 (GAP43) gene, encodes complete protein.
DQ896574 - Synthetic construct Homo sapiens clone IMAGE:100011034; FLH195560.01L; RZPDo839D10151D growth associated protein 43 (GAP43) gene, encodes complete protein.
AB463057 - Synthetic construct DNA, clone: pF1KB8704, Homo sapiens GAP43 gene for growth associated protein 43, without stop codon, in Flexi system.
BT019771 - Homo sapiens growth associated protein 43 mRNA, complete cds.
BT019810 - Homo sapiens growth associated protein 43 mRNA, complete cds.
JD082671 - Sequence 63695 from Patent EP1572962.
JD442051 - Sequence 423075 from Patent EP1572962.
JD437271 - Sequence 418295 from Patent EP1572962.
JD045332 - Sequence 26356 from Patent EP1572962.
JD121802 - Sequence 102826 from Patent EP1572962.
JD390709 - Sequence 371733 from Patent EP1572962.
JD418575 - Sequence 399599 from Patent EP1572962.
JD525891 - Sequence 506915 from Patent EP1572962.
JD195023 - Sequence 176047 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000305124.1, ENST00000305124.10, ENST00000305124.2, ENST00000305124.3, ENST00000305124.4, ENST00000305124.5, ENST00000305124.6, ENST00000305124.7, ENST00000305124.8, ENST00000305124.9, GAP43 , hCG_2022854 , NM_002045, Q5U058, Q5U058_HUMAN, uc317nos.1, uc317nos.2
UCSC ID: ENST00000305124.11_6
RefSeq Accession: NM_002045.4
Protein: Q5U058

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.