Human Gene GAPDH (ENST00000229239.10_4) from GENCODE V47lift37
  Description: glyceraldehyde-3-phosphate dehydrogenase, transcript variant 6 (from RefSeq NR_152150.2)
Gencode Transcript: ENST00000229239.10_4
Gencode Gene: ENSG00000111640.15_8
Transcript (Including UTRs)
   Position: hg19 chr12:6,643,683-6,647,537 Size: 3,855 Total Exon Count: 9 Strand: +
Coding Region
   Position: hg19 chr12:6,643,999-6,647,336 Size: 3,338 Coding Exon Count: 8 

Page IndexSequence and LinksPrimersMalaCardsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureOther SpeciesmRNA DescriptionsPathways
Other NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr12:6,643,683-6,647,537)mRNA (may differ from genome)Protein (335 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedUniProtKB
WikipediaBioGrid CRISPR DB

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: GAPDH
Diseases sorted by gene-association score: fmr1-related disorders (10), schistosomiasis (8), morgagni cataract (7), sleeping sickness (6), papillary hidradenoma (6), alzheimer disease (6), huntington disease (6), erysipeloid (5), primary amebic meningoencephalitis (5), angiomatous meningioma (5), cutaneous anthrax (5), pancreatic gastrinoma (4), lung cancer susceptibility 3 (2), dilated cardiomyopathy (1), malaria (1), retinitis pigmentosa (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 3531.12 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 43435.68 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -14.6076-0.192 Picture PostScript Text
3' UTR -56.40201-0.281 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
      
      

-  Descriptions from all associated GenBank mRNAs
  BC013852 - Homo sapiens glyceraldehyde-3-phosphate dehydrogenase, mRNA (cDNA clone IMAGE:4705312), **** WARNING: chimeric clone ****.
LF207396 - JP 2014500723-A/14899: Polycomb-Associated Non-Coding RNAs.
LQ740471 - Sequence 25 from Patent WO2018083189.
FW577654 - WO 2010131645-A/11: Synthesis method and amplification method of double stranded DNA corresponding to RNA.
JB343260 - Sequence 11 from Patent EP2431465.
AF261085 - Homo sapiens glyceraldehyde-3-phosphate dehydrogenase (GADPH) mRNA, complete cds.
EU668321 - Homo sapiens epididymis secretory sperm binding protein Li 162eP (HEL-S-162eP) mRNA, complete cds.
AK308198 - Homo sapiens cDNA, FLJ98146.
AK026525 - Homo sapiens cDNA: FLJ22872 fis, clone KAT02551, highly similar to HUMGAPDH Human glyceraldehyde-3-phosphate dehydrogenase (GAPDH) mRNA.
AK299448 - Homo sapiens cDNA FLJ58855 complete cds, highly similar to Glyceraldehyde-3-phosphate dehydrogenase (EC 1.2.1.12).
U34995 - Human normal keratinocyte substraction library mRNA, clone H22a, complete sequence.
JD428110 - Sequence 409134 from Patent EP1572962.
BC009081 - Homo sapiens glyceraldehyde-3-phosphate dehydrogenase, mRNA (cDNA clone MGC:9901 IMAGE:3869809), complete cds.
M33197 - Human glyceraldehyde-3-phosphate dehydrogenase (GAPDH) mRNA, complete cds.
BC013310 - Homo sapiens glyceraldehyde-3-phosphate dehydrogenase, mRNA (cDNA clone MGC:4765 IMAGE:3538383), complete cds.
BC025925 - Homo sapiens glyceraldehyde-3-phosphate dehydrogenase, mRNA (cDNA clone MGC:15497 IMAGE:2989348), complete cds.
BC029618 - Homo sapiens glyceraldehyde-3-phosphate dehydrogenase, mRNA (cDNA clone MGC:9949 IMAGE:3876535), complete cds.
X53778 - H.sapiens hng mRNA for uracil DNA glycosylase.
AB062273 - Homo sapiens OK/SW-cl.12 mRNA for glyceraldehyde-3-phosphate dehydrogenase, complete cds.
AY007133 - Homo sapiens clone CDABP0047 mRNA sequence.
BC004109 - Homo sapiens glyceraldehyde-3-phosphate dehydrogenase, mRNA (cDNA clone MGC:11042 IMAGE:3678259), complete cds.
BC083511 - Homo sapiens glyceraldehyde-3-phosphate dehydrogenase, mRNA (cDNA clone MGC:88685 IMAGE:3536969), complete cds.
BC029340 - Homo sapiens glyceraldehyde-3-phosphate dehydrogenase, mRNA (cDNA clone IMAGE:3917859).
BC001601 - Homo sapiens glyceraldehyde-3-phosphate dehydrogenase, mRNA (cDNA clone MGC:2031 IMAGE:3543589), complete cds.
BC020308 - Homo sapiens glyceraldehyde-3-phosphate dehydrogenase, mRNA (cDNA clone IMAGE:4938218).
BC026907 - Homo sapiens glyceraldehyde-3-phosphate dehydrogenase, mRNA (cDNA clone MGC:25010 IMAGE:4454083), complete cds.
JD383664 - Sequence 364688 from Patent EP1572962.
M17851 - Human glyceraldehyde-3-phosphate dehydrogenase mRNA, complete cds.
AY633612 - Homo sapiens aging-associated gene 9 protein mRNA, complete cds.
BC023632 - Homo sapiens glyceraldehyde-3-phosphate dehydrogenase, mRNA (cDNA clone MGC:23503 IMAGE:4842418), complete cds.
X01677 - Human liver mRNA for glyceraldehyde-3-phosphate dehydrogenase (G3PD, EC 1.2.1.12).
DQ891557 - Synthetic construct clone IMAGE:100004187; FLH178037.01X; RZPDo839G08126D glyceraldehyde-3-phosphate dehydrogenase (GAPDH) gene, encodes complete protein.
DQ894744 - Synthetic construct Homo sapiens clone IMAGE:100009204; FLH178033.01L; RZPDo839G08125D glyceraldehyde-3-phosphate dehydrogenase (GAPDH) gene, encodes complete protein.
AB463693 - Synthetic construct DNA, clone: pF1KB8252, Homo sapiens GAPDH gene for glyceraldehyde-3-phosphate dehydrogenase, without stop codon, in Flexi system.
CU679249 - Synthetic construct Homo sapiens gateway clone IMAGE:100020686 5' read GAPDH mRNA.
KJ891221 - Synthetic construct Homo sapiens clone ccsbBroadEn_00615 GAPDH gene, encodes complete protein.
KJ896860 - Synthetic construct Homo sapiens clone ccsbBroadEn_06254 hypothetical protein, encodes complete protein.
J02642 - Human glyceraldehyde 3-phosphate dehydrogenase mRNA.
CR407671 - Homo sapiens full open reading frame cDNA clone RZPDo834B103D for gene GAPD, glyceraldehyde-3-phosphate dehydrogenase complete cds, without stopcodon.
BT006893 - Homo sapiens glyceraldehyde-3-phosphate dehydrogenase mRNA, complete cds.
DL491527 - Novel nucleic acids.
DL490133 - Novel nucleic acids.
JD425761 - Sequence 406785 from Patent EP1572962.
DQ403057 - Homo sapiens glyceraldehyde-3-phosphate dehydrogenase (GAPDH) mRNA, partial cds.
JD496800 - Sequence 477824 from Patent EP1572962.
AJ844644 - Homo sapiens partial mRNA for glyceraldehyde-3-phosphate dehydrogenase (GAPD gene), 5' end.
HQ727992 - Homo sapiens clone MVRG GAPDH glyceraldehyde-3-phosphate dehydrogenase mRNA, partial cds.
LF367665 - JP 2014500723-A/175168: Polycomb-Associated Non-Coding RNAs.
EF036498 - Homo sapiens glyceraldehyde 3-phosphate dehydrogenase mRNA, partial cds.
JD026412 - Sequence 7436 from Patent EP1572962.
JD019283 - Sequence 307 from Patent EP1572962.
JD022906 - Sequence 3930 from Patent EP1572962.
JD025299 - Sequence 6323 from Patent EP1572962.
JD021468 - Sequence 2492 from Patent EP1572962.
JD033161 - Sequence 14185 from Patent EP1572962.
JD020481 - Sequence 1505 from Patent EP1572962.
JD034077 - Sequence 15101 from Patent EP1572962.
JD035524 - Sequence 16548 from Patent EP1572962.
JD035525 - Sequence 16549 from Patent EP1572962.
AJ844645 - Homo sapiens partial mRNA for glyceraldehyde-3-phosphate dehydrogenase (GAPD gene).
JD023186 - Sequence 4210 from Patent EP1572962.
JD024137 - Sequence 5161 from Patent EP1572962.
JD026845 - Sequence 7869 from Patent EP1572962.
JD027924 - Sequence 8948 from Patent EP1572962.
LF345249 - JP 2014500723-A/152752: Polycomb-Associated Non-Coding RNAs.
DM107627 - METHODS FOR GENERATING NEW HAIR FOLLICLES, TREATING BALDNESS, AND HAIR REMOVAL.
HW120631 - JP 2013049691-A/186: METHODS FOR GENERATING NEW HAIR FOLLICLES, TREATING BALDNESS, AND HAIR REMOVAL.
LF858734 - JP 2015172074-A/186: METHODS FOR GENERATING NEW HAIR FOLLICLES, TREATING BALDNESS, AND HAIR REMOVAL.
JD029546 - Sequence 10570 from Patent EP1572962.
M28283 - Human glyceraldehyde 3-phosphate-dehydrogenase mRNA, 3' end.
M36164 - Human glyceraldehyde-3-phosphate dehydrogenase mRNA, 3' flank.
JD470317 - Sequence 451341 from Patent EP1572962.
JD470318 - Sequence 451342 from Patent EP1572962.
LF346578 - JP 2014500723-A/154081: Polycomb-Associated Non-Coding RNAs.
LF365889 - JP 2014500723-A/173392: Polycomb-Associated Non-Coding RNAs.
LF325083 - JP 2014500723-A/132586: Polycomb-Associated Non-Coding RNAs.
JD067444 - Sequence 48468 from Patent EP1572962.
JD043755 - Sequence 24779 from Patent EP1572962.
JD043756 - Sequence 24780 from Patent EP1572962.
LF354921 - JP 2014500723-A/162424: Polycomb-Associated Non-Coding RNAs.
JD443461 - Sequence 424485 from Patent EP1572962.
LF365887 - JP 2014500723-A/173390: Polycomb-Associated Non-Coding RNAs.
MA726084 - JP 2017114907-A/186: METHODS FOR GENERATING NEW HAIR FOLLICLES, TREATING BALDNESS, AND HAIR REMOVAL.
MA603242 - JP 2018138019-A/175168: Polycomb-Associated Non-Coding RNAs.
MA580826 - JP 2018138019-A/152752: Polycomb-Associated Non-Coding RNAs.
MA582155 - JP 2018138019-A/154081: Polycomb-Associated Non-Coding RNAs.
MA601466 - JP 2018138019-A/173392: Polycomb-Associated Non-Coding RNAs.
MA560660 - JP 2018138019-A/132586: Polycomb-Associated Non-Coding RNAs.
MA601464 - JP 2018138019-A/173390: Polycomb-Associated Non-Coding RNAs.
MA442973 - JP 2018138019-A/14899: Polycomb-Associated Non-Coding RNAs.
MA590498 - JP 2018138019-A/162424: Polycomb-Associated Non-Coding RNAs.
MB015997 - JP 2018503403-A/8: Ligation Assays in Liquid Phase.
MB015993 - JP 2018503403-A/4: Ligation Assays in Liquid Phase.
MB015994 - JP 2018503403-A/5: Ligation Assays in Liquid Phase.
MB015995 - JP 2018503403-A/6: Ligation Assays in Liquid Phase.

-  Biochemical and Signaling Pathways
  BioCyc Knowledge Library
PWY-6938 - NADH repair
PWY66-399 - gluconeogenesis
PWY66-400 - glycolysis
PWY66-407 - superpathway of conversion of glucose to acetyl CoA and entry into the TCA cycle

BioCarta from NCI Cancer Genome Anatomy Project
h_mta3Pathway - Downregulated of MTA-3 in ER-negative Breast Tumors
h_glycolysisPathway - Glycolysis Pathway

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000229239.1, ENST00000229239.2, ENST00000229239.3, ENST00000229239.4, ENST00000229239.5, ENST00000229239.6, ENST00000229239.7, ENST00000229239.8, ENST00000229239.9, HEL-S-162eP , NR_152150, uc317dpv.1, uc317dpv.2, V9HVZ4, V9HVZ4_HUMAN
UCSC ID: ENST00000229239.10_4
RefSeq Accession: NM_002046.7

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.