ID:GDIA_HUMAN DESCRIPTION: RecName: Full=Rab GDP dissociation inhibitor alpha; Short=Rab GDI alpha; AltName: Full=Guanosine diphosphate dissociation inhibitor 1; Short=GDI-1; AltName: Full=Oligophrenin-2; AltName: Full=Protein XAP-4; FUNCTION: Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. SUBUNIT: Interacts with RHOH. Interacts with RAB10; negatively regulates RAB10 association with membranes and activation. SUBCELLULAR LOCATION: Cytoplasm (By similarity). TISSUE SPECIFICITY: Brain; predominant in neural and sensory tissues. DISEASE: Defects in GDI1 are the cause of mental retardation X- linked type 41 (MRX41) [MIM:300849]. Mental retardation is characterized by significantly sub-average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. Non-syndromic mental retardation patients do not manifest other clinical signs. SIMILARITY: Belongs to the Rab GDI family. WEB RESOURCE: Name=GeneReviews; URL="http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/MRX3";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P31150
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0007165 signal transduction GO:0007264 small GTPase mediated signal transduction GO:0015031 protein transport GO:0032482 Rab protein signal transduction GO:0043547 positive regulation of GTPase activity GO:0045773 positive regulation of axon extension GO:0050771 negative regulation of axonogenesis GO:0050790 regulation of catalytic activity GO:0051056 regulation of small GTPase mediated signal transduction GO:0051592 response to calcium ion GO:0090315 negative regulation of protein targeting to membrane
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
