ID:EFGM_HUMAN DESCRIPTION: RecName: Full=Elongation factor G, mitochondrial; Short=EF-Gmt; AltName: Full=Elongation factor G 1, mitochondrial; Short=mEF-G 1; AltName: Full=Elongation factor G1; Short=hEFG1; Flags: Precursor; FUNCTION: Mitochondrial GTPase that catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A- site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome. Does not mediate the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis. PATHWAY: Protein biosynthesis; polypeptide chain elongation. SUBCELLULAR LOCATION: Mitochondrion (By similarity). DISEASE: Defects in GFM1 are the cause of combined oxidative phosphorylation deficiency type 1 (COXPD1) [MIM:609060]. It leads to early fatal progressive hepatoencephalopathy. SIMILARITY: Belongs to the GTP-binding elongation factor family. EF-G/EF-2 subfamily. SEQUENCE CAUTION: Sequence=EAW78682.1; Type=Erroneous gene model prediction; WEB RESOURCE: Name=GeneReviews; URL="http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/GFM1";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q96RP9
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
AK000780 - Homo sapiens cDNA FLJ20773 fis, clone COL06050, highly similar to EFGM_RAT ELONGATION FACTOR G. AF367998 - Homo sapiens elongation factor G1 (EFG1) mRNA, complete cds; nuclear gene for mitochondrial product. AF309777 - Homo sapiens elongation factor G (EFG) mRNA, complete cds; nuclear gene for mitochondrial product. BC049210 - Homo sapiens G elongation factor, mitochondrial 1, mRNA (cDNA clone MGC:51775 IMAGE:5574223), complete cds. AK315031 - Homo sapiens cDNA, FLJ95973, highly similar to Homo sapiens G elongation factor, mitochondrial 1 (GFM1), nuclear gene encoding mitochondrial protein, mRNA. CU690604 - Synthetic construct Homo sapiens gateway clone IMAGE:100021549 5' read GFM1 mRNA. KJ895090 - Synthetic construct Homo sapiens clone ccsbBroadEn_04484 GFM1 gene, encodes complete protein. KR711044 - Synthetic construct Homo sapiens clone CCSBHm_00019434 GFM1 (GFM1) mRNA, encodes complete protein. KR711045 - Synthetic construct Homo sapiens clone CCSBHm_00019435 GFM1 (GFM1) mRNA, encodes complete protein. KR711046 - Synthetic construct Homo sapiens clone CCSBHm_00019436 GFM1 (GFM1) mRNA, encodes complete protein. KU178816 - Homo sapiens G elongation factor mitochondrial 1 isoform 1 (GFM1) mRNA, partial cds; nuclear gene for mitochondrial product. KU178817 - Homo sapiens G elongation factor mitochondrial 1 isoform 3 (GFM1) mRNA, complete cds, alternatively spliced; nuclear gene for mitochondrial product. AK092293 - Homo sapiens cDNA FLJ34974 fis, clone NTONG2005520, highly similar to Elongation factor G1, mitochondrial precursor. AX747457 - Sequence 982 from Patent EP1308459. AK023694 - Homo sapiens cDNA FLJ13632 fis, clone PLACE1011109, weakly similar to ELONGATION FACTOR G, MITOCHONDRIAL PRECURSOR. AK022724 - Homo sapiens cDNA FLJ12662 fis, clone NT2RM4002205, moderately similar to ELONGATION FACTOR G, MITOCHONDRIAL PRECURSOR. JD357655 - Sequence 338679 from Patent EP1572962. JD184104 - Sequence 165128 from Patent EP1572962. JD235351 - Sequence 216375 from Patent EP1572962. JD355963 - Sequence 336987 from Patent EP1572962. JD274319 - Sequence 255343 from Patent EP1572962. JD164284 - Sequence 145308 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q96RP9 (Reactome details) participates in the following event(s):
R-HSA-5419279 Translocation of peptidyl-tRNA from A-site to P-site (and translocation of 55S ribosome by 3 bases along mRNA) R-HSA-5419261 55S ribosome with peptidyl-tRNA in A site binds GFM1:GTP R-HSA-5389840 Mitochondrial translation elongation R-HSA-5368287 Mitochondrial translation R-HSA-72766 Translation R-HSA-392499 Metabolism of proteins
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
