Human Gene GHRH (ENST00000373614.7_10) from GENCODE V47lift37
  Description: growth hormone releasing hormone, transcript variant 1 (from RefSeq NM_021081.6)
Gencode Transcript: ENST00000373614.7_10
Gencode Gene: ENSG00000118702.11_13
Transcript (Including UTRs)
   Position: hg19 chr20:35,879,489-35,890,217 Size: 10,729 Total Exon Count: 5 Strand: -
Coding Region
   Position: hg19 chr20:35,879,616-35,885,292 Size: 5,677 Coding Exon Count: 4 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr20:35,879,489-35,890,217)mRNA (may differ from genome)Protein (108 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedReactome
UniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: SLIB_HUMAN
DESCRIPTION: RecName: Full=Somatoliberin; AltName: Full=Growth hormone-releasing factor; Short=GRF; AltName: Full=Growth hormone-releasing hormone; Short=GHRH; AltName: Full=Somatocrinin; AltName: Full=Somatorelin; AltName: INN=Sermorelin; Flags: Precursor;
FUNCTION: GRF is released by the hypothalamus and acts on the adenohypophyse to stimulate the secretion of growth hormone.
SUBCELLULAR LOCATION: Secreted.
PHARMACEUTICAL: Available under the names Groliberin (Pharmacia) or Somatrel (Ferring). Also available under the name Geref (Serono). Geref is a synthetic acetylated form of residues 1 to 29 of GHRH. Used for the treatment of growth hormone deficiency.
SIMILARITY: Belongs to the glucagon family.
WEB RESOURCE: Name=Wikipedia; Note=Growth hormone releasing hormone entry; URL="http://en.wikipedia.org/wiki/Growth_hormone_releasing_hormone";

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: GHRH
Diseases sorted by gene-association score: isolated growth hormone deficiency, ghrh-related* (100), gigantism (19), growth hormone deficiency (14), dwarfism (13), isolated growth hormone deficiency (12), acromegaly (11), hyperpituitarism (11), hypopituitarism (10), growth hormone deficiency, isolated, type ib (9), glucagonoma (9), sella turcica neoplasm (8), tuberculum sellae meningioma (8), pituitary adenoma (8), anorexia nervosa (7), hypothalamic disease (6), adrenal gland hyperfunction (6), growth hormone deficiency, isolated, type ii (6), pituitary gland disease (5), pituitary-dependent cushing's disease (5), carcinoid syndrome (5), peliosis hepatis (4), serotonin syndrome (4), pancreatic cholera (4), chromophobe adenoma (4), endocrine organ benign neoplasm (4), mitochondrial encephalomyopathy (2), multiple endocrine neoplasia 1 (2), insulin-like growth factor i (2), endocrine pancreas disease (1), obesity (1)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 3.53 RPKM in Heart - Atrial Appendage
Total median expression: 5.90 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -31.2091-0.343 Picture PostScript Text
3' UTR -18.60127-0.146 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000532 - Glucagon_GIP_secretin_VIP

Pfam Domains:
PF00123 - Peptide hormone

ModBase Predicted Comparative 3D Structure on P01286
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005179 hormone activity
GO:0016608 growth hormone-releasing hormone activity
GO:0031770 growth hormone-releasing hormone receptor binding

Biological Process:
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway
GO:0007267 cell-cell signaling
GO:0008284 positive regulation of cell proliferation
GO:0010469 regulation of receptor activity
GO:0021984 adenohypophysis development
GO:0030252 growth hormone secretion
GO:0032094 response to food
GO:0040018 positive regulation of multicellular organism growth
GO:0043568 positive regulation of insulin-like growth factor receptor signaling pathway
GO:0046005 positive regulation of circadian sleep/wake cycle, REM sleep
GO:0046887 positive regulation of hormone secretion
GO:0060124 positive regulation of growth hormone secretion

Cellular Component:
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005622 intracellular
GO:0043195 terminal bouton


-  Descriptions from all associated GenBank mRNAs
  KJ891241 - Synthetic construct Homo sapiens clone ccsbBroadEn_00635 GHRH gene, encodes complete protein.
KJ891242 - Synthetic construct Homo sapiens clone ccsbBroadEn_00636 GHRH gene, encodes complete protein.
KR711472 - Synthetic construct Homo sapiens clone CCSBHm_00024296 GHRH (GHRH) mRNA, encodes complete protein.
E00273 - cDNA coding for human pancreas growth hormone-releasing factor(tpGRF).
E00274 - cDNA coding for hpGRF(human pancreas Hormone-Releasing factor).
X00094 - Human mRNA for growth hormone-releasing factor (hpGRF).
BC098109 - Homo sapiens growth hormone releasing hormone, mRNA (cDNA clone MGC:119778 IMAGE:40014055), complete cds.
BC098161 - Homo sapiens growth hormone releasing hormone, mRNA (cDNA clone MGC:119780 IMAGE:40014060), complete cds.
BC099727 - Homo sapiens growth hormone releasing hormone, mRNA (cDNA clone MGC:119781 IMAGE:40014061), complete cds.

-  Biochemical and Signaling Pathways
  BioCarta from NCI Cancer Genome Anatomy Project
h_ghrelinPathway - Ghrelin: Regulation of Food Intake and Energy Homeostasis

Reactome (by CSHL, EBI, and GO)

Protein P01286 (Reactome details) participates in the following event(s):

R-HSA-420243 GHRH receptor binds GHRH
R-HSA-744886 The Ligand:GPCR:Gs complex dissociates
R-HSA-744887 Liganded Gs-activating GPCRs bind inactive heterotrimeric Gs
R-HSA-379044 Liganded Gs-activating GPCR acts as a GEF for Gs
R-HSA-420092 Glucagon-type ligand receptors
R-HSA-418555 G alpha (s) signalling events
R-HSA-373080 Class B/2 (Secretin family receptors)
R-HSA-388396 GPCR downstream signalling
R-HSA-500792 GPCR ligand binding
R-HSA-372790 Signaling by GPCR
R-HSA-162582 Signal Transduction

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000373614.1, ENST00000373614.2, ENST00000373614.3, ENST00000373614.4, ENST00000373614.5, ENST00000373614.6, GHRF, NM_021081, P01286, Q4KN10, Q5JYR1, SLIB_HUMAN, uc318kxo.1, uc318kxo.2
UCSC ID: ENST00000373614.7_10
RefSeq Accession: NM_021081.6
Protein: P01286 (aka SLIB_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.