Human Gene GIP (ENST00000357424.2_7) from GENCODE V47lift37
  Description: gastric inhibitory polypeptide (from RefSeq NM_004123.3)
Gencode Transcript: ENST00000357424.2_7
Gencode Gene: ENSG00000159224.4_8
Transcript (Including UTRs)
   Position: hg19 chr17:47,035,916-47,045,958 Size: 10,043 Total Exon Count: 6 Strand: -
Coding Region
   Position: hg19 chr17:47,036,069-47,044,594 Size: 8,526 Coding Exon Count: 5 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr17:47,035,916-47,045,958)mRNA (may differ from genome)Protein (153 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedReactome
UniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: GIP_HUMAN
DESCRIPTION: RecName: Full=Gastric inhibitory polypeptide; Short=GIP; AltName: Full=Glucose-dependent insulinotropic polypeptide; AltName: Full=Incretin hormone; Flags: Precursor;
FUNCTION: Potent stimulator of insulin secretion and relatively poor inhibitor of gastric acid secretion.
SUBCELLULAR LOCATION: Secreted.
SIMILARITY: Belongs to the glucagon family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: GIP
Diseases sorted by gene-association score: dumping syndrome (10), postgastrectomy syndrome (8), pancreatic cholera (5), endocrine pancreas disease (5), glucose metabolism disease (4), hyperglycemia (4), diabetes mellitus, noninsulin-dependent (3), diabetes mellitus, insulin-dependent (2), acquired metabolic disease (2), pancreas disease (1), obesity (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 0.36 RPKM in Testis
Total median expression: 0.40 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -35.50101-0.351 Picture PostScript Text
3' UTR -20.10153-0.131 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000532 - Glucagon_GIP_secretin_VIP

Pfam Domains:
PF00123 - Peptide hormone

Protein Data Bank (PDB) 3-D Structure
MuPIT help
1T5Q - NMR 2B4N - NMR 2L70 - NMR 2L71 - NMR 2OBU - NMR 2QKH - X-ray MuPIT


ModBase Predicted Comparative 3D Structure on P09681
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005102 receptor binding
GO:0005179 hormone activity
GO:0005515 protein binding

Biological Process:
GO:0007165 signal transduction
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007565 female pregnancy
GO:0007613 memory
GO:0008344 adult locomotory behavior
GO:0009743 response to carbohydrate
GO:0009749 response to glucose
GO:0010269 response to selenium ion
GO:0010447 response to acidic pH
GO:0010469 regulation of receptor activity
GO:0010828 positive regulation of glucose transport
GO:0014070 response to organic cyclic compound
GO:0019233 sensory perception of pain
GO:0031018 endocrine pancreas development
GO:0031667 response to nutrient levels
GO:0032024 positive regulation of insulin secretion
GO:0033993 response to lipid
GO:0035640 exploration behavior
GO:0042493 response to drug
GO:0042594 response to starvation
GO:0043200 response to amino acid
GO:0043434 response to peptide hormone
GO:0043950 positive regulation of cAMP-mediated signaling
GO:0048678 response to axon injury
GO:0050796 regulation of insulin secretion
GO:0050806 positive regulation of synaptic transmission
GO:0055123 digestive system development
GO:0060291 long-term synaptic potentiation
GO:0070094 positive regulation of glucagon secretion
GO:0070328 triglyceride homeostasis

Cellular Component:
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0005788 endoplasmic reticulum lumen
GO:0034774 secretory granule lumen
GO:0043025 neuronal cell body


-  Descriptions from all associated GenBank mRNAs
  E02006 - cDNA encoding human gastric inhibitory polypeptide precursor.
BC069100 - Homo sapiens gastric inhibitory polypeptide, mRNA (cDNA clone MGC:95375 IMAGE:7216914), complete cds.
M18185 - Human gastric inhibitory polypeptide (GIP) mRNA, complete cds.
BC069663 - Homo sapiens gastric inhibitory polypeptide, mRNA (cDNA clone MGC:97293 IMAGE:7262542), complete cds.
BC069686 - Homo sapiens gastric inhibitory polypeptide, mRNA (cDNA clone MGC:97305 IMAGE:7262554), complete cds.
BC069746 - Homo sapiens gastric inhibitory polypeptide, mRNA (cDNA clone MGC:97317 IMAGE:7262566), complete cds.
JD422560 - Sequence 403584 from Patent EP1572962.
JD260968 - Sequence 241992 from Patent EP1572962.
BC096148 - Homo sapiens gastric inhibitory polypeptide, mRNA (cDNA clone MGC:116796 IMAGE:40002923), complete cds.
BC096149 - Homo sapiens gastric inhibitory polypeptide, mRNA (cDNA clone MGC:116797 IMAGE:40002925), complete cds.
BC096147 - Homo sapiens gastric inhibitory polypeptide, mRNA (cDNA clone MGC:116795 IMAGE:40002922), complete cds.
BC096146 - Homo sapiens gastric inhibitory polypeptide, mRNA (cDNA clone MGC:116794 IMAGE:40002916), complete cds.
CU686958 - Synthetic construct Homo sapiens gateway clone IMAGE:100022576 5' read GIP mRNA.
HQ448468 - Synthetic construct Homo sapiens clone IMAGE:100071897; CCSB014017_01 gastric inhibitory polypeptide (GIP) gene, encodes complete protein.
KJ891244 - Synthetic construct Homo sapiens clone ccsbBroadEn_00638 GIP gene, encodes complete protein.
KJ896879 - Synthetic construct Homo sapiens clone ccsbBroadEn_06273 GIP gene, encodes complete protein.
JD390352 - Sequence 371376 from Patent EP1572962.
JD381973 - Sequence 362997 from Patent EP1572962.
MP574246 - Sequence 3 from Patent WO2020067557.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein P09681 (Reactome details) participates in the following event(s):

R-HSA-400496 Signal peptidase hydrolyzes preproGIP to proGIP
R-HSA-400492 PCSK1 hydrolyzes proGIP to GIP
R-HSA-420274 GIP receptor binds gastric inhibitory peptide
R-HSA-9023626 DPP4(39-766) hydrolyzes Glucose-dependent Insulinotropic Polypeptide (GIP)
R-HSA-9023627 DPP4(1-766) hydrolyzes Glucose-dependent Insulinotropic Polypeptide (GIP)
R-HSA-744886 The Ligand:GPCR:Gs complex dissociates
R-HSA-744887 Liganded Gs-activating GPCRs bind inactive heterotrimeric Gs
R-HSA-379044 Liganded Gs-activating GPCR acts as a GEF for Gs
R-HSA-400511 Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
R-HSA-420092 Glucagon-type ligand receptors
R-HSA-400508 Incretin synthesis, secretion, and inactivation
R-HSA-418555 G alpha (s) signalling events
R-HSA-373080 Class B/2 (Secretin family receptors)
R-HSA-2980736 Peptide hormone metabolism
R-HSA-388396 GPCR downstream signalling
R-HSA-500792 GPCR ligand binding
R-HSA-392499 Metabolism of proteins
R-HSA-372790 Signaling by GPCR
R-HSA-162582 Signal Transduction

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000357424.1, GIP_HUMAN, NM_004123, P09681, Q4VB42, Q6NTD3, uc318aas.1, uc318aas.2
UCSC ID: ENST00000357424.2_7
RefSeq Accession: NM_004123.3
Protein: P09681 (aka GIP_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.