ID:CXG1_HUMAN DESCRIPTION: RecName: Full=Gap junction gamma-1 protein; AltName: Full=Connexin-45; Short=Cx45; AltName: Full=Gap junction alpha-7 protein; FUNCTION: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. SUBUNIT: A connexon is composed of a hexamer of connexins. Interacts with CNST (By similarity). SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Cell junction, gap junction. SIMILARITY: Belongs to the connexin family. Gamma-type subfamily.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P36383
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0005216 ion channel activity GO:0005243 gap junction channel activity GO:0086020 gap junction channel activity involved in SA node cell-atrial cardiac muscle cell electrical coupling GO:0086077 gap junction channel activity involved in AV node cell-bundle of His cell electrical coupling
Biological Process: GO:0001570 vasculogenesis GO:0006936 muscle contraction GO:0007043 cell-cell junction assembly GO:0007154 cell communication GO:0007267 cell-cell signaling GO:0007268 chemical synaptic transmission GO:0007507 heart development GO:0007601 visual perception GO:0016264 gap junction assembly GO:0034220 ion transmembrane transport GO:0048468 cell development GO:0048738 cardiac muscle tissue development GO:0055085 transmembrane transport GO:0086014 atrial cardiac muscle cell action potential GO:0086021 SA node cell to atrial cardiac muscle cell communication by electrical coupling GO:0086053 AV node cell to bundle of His cell communication by electrical coupling
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
