ID:CXG3_HUMAN DESCRIPTION: RecName: Full=Gap junction gamma-3 protein; AltName: Full=Connexin-30.2; Short=Cx30.2; AltName: Full=Connexin-31.3; Short=Cx31.3; AltName: Full=Gap junction epsilon-1 protein; FUNCTION: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell (By similarity). SUBUNIT: A connexon is composed of a hexamer of connexins (By similarity). SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein (By similarity). Cell junction, gap junction (By similarity). TISSUE SPECIFICITY: CNS specific. Expression is restricted to brain, spinal cord, and sciatic nerve. According to PubMed:12881038, expression is abundant in skeletal muscle, liver, and heart, and to a minor degree in pancreas and kidney. SIMILARITY: Belongs to the connexin family. Gamma-type subfamily.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q8NFK1
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0042803 protein homodimerization activity GO:0086077 gap junction channel activity involved in AV node cell-bundle of His cell electrical coupling
Biological Process: GO:0007154 cell communication GO:0007605 sensory perception of sound GO:0042552 myelination GO:0086053 AV node cell to bundle of His cell communication by electrical coupling
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
