ID:GUAA_HUMAN DESCRIPTION: RecName: Full=GMP synthase [glutamine-hydrolyzing]; EC=6.3.5.2; AltName: Full=GMP synthetase; AltName: Full=Glutamine amidotransferase; FUNCTION: Involved in the de novo synthesis of guanine nucleotides which are not only essential for DNA and RNA synthesis, but also provide GTP, which is involved in a number of cellular processes important for cell division. CATALYTIC ACTIVITY: ATP + xanthosine 5'-phosphate + L-glutamine + H(2)O = AMP + diphosphate + GMP + L-glutamate. PATHWAY: Purine metabolism; GMP biosynthesis; GMP from XMP (L-Gln route): step 1/1. SUBUNIT: Homodimer (By similarity). SUBCELLULAR LOCATION: Cytoplasm. DISEASE: Note=A chromosomal aberration involving GMPS is found in acute myeloid leukemias. Translocation t(3,11)(q25,q23) with MLL. SIMILARITY: Contains 1 glutamine amidotransferase type-1 domain. SIMILARITY: Contains 1 GMPS ATP-PPase (ATP pyrophosphatase) domain. WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/GMPSID229.html";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P49915
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
BioCyc Knowledge Library PWY-5921 - glutaminyl-tRNAgln biosynthesis via transamidation PWY-7221 - guanosine ribonucleotides de novo biosynthesis PWY-7228 - guanosine nucleotides de novo biosynthesis PWY-841 - purine nucleotides de novo biosynthesis PWY66-409 - superpathway of purine nucleotide salvage
Reactome (by CSHL, EBI, and GO)
Protein P49915 (Reactome details) participates in the following event(s):
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
