ID:GNA12_HUMAN DESCRIPTION: RecName: Full=Guanine nucleotide-binding protein subunit alpha-12; Short=G alpha-12; Short=G-protein subunit alpha-12; FUNCTION: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. SUBUNIT: G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site. Interacts with UBXD5. SUBCELLULAR LOCATION: Membrane; Lipid-anchor. SIMILARITY: Belongs to the G-alpha family. G(12) subfamily.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q03113
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0001701 in utero embryonic development GO:0007165 signal transduction GO:0007186 G-protein coupled receptor signaling pathway GO:0007188 adenylate cyclase-modulating G-protein coupled receptor signaling pathway GO:0007266 Rho protein signal transduction GO:0007596 blood coagulation GO:0008360 regulation of cell shape GO:0010762 regulation of fibroblast migration GO:0030154 cell differentiation GO:0030168 platelet activation GO:0032006 regulation of TOR signaling GO:0032434 regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0035556 intracellular signal transduction GO:0042493 response to drug GO:0042733 embryonic digit morphogenesis
BC111464 - Homo sapiens guanine nucleotide binding protein (G protein) alpha 12, mRNA (cDNA clone MGC:104623 IMAGE:5264798), complete cds. BC087537 - Homo sapiens guanine nucleotide binding protein (G protein) alpha 12, mRNA (cDNA clone MGC:99644 IMAGE:6208783), complete cds. AK295830 - Homo sapiens cDNA FLJ55846 complete cds, highly similar to Guanine nucleotide-binding protein alpha-12 subunit. AF493901 - Homo sapiens guanine nucleotide binding protein alpha 12 (GNA12) mRNA, complete cds. L01694 - Homo sapiens (clone 58N-1) Ga subunit mRNA, complete cds. AB463060 - Synthetic construct DNA, clone: pF1KB3987, Homo sapiens GNA12 gene for guanine nucleotide binding protein (G protein) alpha 12, without stop codon, in Flexi system. AK024696 - Homo sapiens cDNA: FLJ21043 fis, clone CAE11633. JD487657 - Sequence 468681 from Patent EP1572962. AK025582 - Homo sapiens cDNA: FLJ21929 fis, clone HEP04272. AL512719 - Homo sapiens mRNA; cDNA DKFZp547G142 (from clone DKFZp547G142). BC063396 - Homo sapiens cDNA clone IMAGE:5180285, partial cds. BC007400 - Homo sapiens guanine nucleotide binding protein (G protein) alpha 12, mRNA (cDNA clone IMAGE:3837892), partial cds. BC009457 - Homo sapiens guanine nucleotide binding protein (G protein) alpha 12, mRNA (cDNA clone IMAGE:3536596). AK024834 - Homo sapiens cDNA: FLJ21181 fis, clone CAS11503. AK025894 - Homo sapiens cDNA: FLJ22241 fis, clone HRC02524. AK127842 - Homo sapiens cDNA FLJ45945 fis, clone PLACE7006498, highly similar to Guanine nucleotide-binding protein alpha-12 subunit. AK128701 - Homo sapiens cDNA FLJ46868 fis, clone UTERU3012414, highly similar to Guanine nucleotide-binding protein, alpha-12 subunit. JD202588 - Sequence 183612 from Patent EP1572962. JD534023 - Sequence 515047 from Patent EP1572962. JD398481 - Sequence 379505 from Patent EP1572962. JD163991 - Sequence 145015 from Patent EP1572962. JD326590 - Sequence 307614 from Patent EP1572962. JD404788 - Sequence 385812 from Patent EP1572962. JD350506 - Sequence 331530 from Patent EP1572962. JD263373 - Sequence 244397 from Patent EP1572962. KJ901457 - Synthetic construct Homo sapiens clone ccsbBroadEn_10851 GNA12 gene, encodes complete protein. JD295384 - Sequence 276408 from Patent EP1572962. JD480790 - Sequence 461814 from Patent EP1572962. JD539212 - Sequence 520236 from Patent EP1572962. JD369494 - Sequence 350518 from Patent EP1572962. JD457845 - Sequence 438869 from Patent EP1572962. JD335919 - Sequence 316943 from Patent EP1572962. JD543077 - Sequence 524101 from Patent EP1572962. JD549327 - Sequence 530351 from Patent EP1572962. JD251065 - Sequence 232089 from Patent EP1572962. JD357805 - Sequence 338829 from Patent EP1572962. AK122830 - Homo sapiens cDNA FLJ16438 fis, clone BRAMY2019643, highly similar to GUANINE NUCLEOTIDE-BINDING PROTEIN, ALPHA-12 SUBUNIT.
Biochemical and Signaling Pathways
BioCarta from NCI Cancer Genome Anatomy Project h_Par1Pathway - Thrombin signaling and protease-activated receptors h_myosinPathway - PKC-catalyzed phosphorylation of inhibitory phosphoprotein of myosin phosphatase h_akap13Pathway - Rho-Selective Guanine Exchange Factor AKAP13 Mediates Stress Fiber Formation
Reactome (by CSHL, EBI, and GO)
Protein Q03113 (Reactome details) participates in the following event(s):
R-HSA-398184 LARG activation by G alpha 12/13 R-HSA-418574 G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP R-HSA-397891 Dissociation of the PAR:G12/13 complex R-HSA-751019 The Ligand:GPCR:G12/13 complex dissociates R-HSA-751039 Inactive G alpha (12/13) reassociates with G beta:gamma R-HSA-398185 LARG binds plexin B1 R-HSA-396941 Thrombin-activated PAR binds G-protein G12/13 R-HSA-751027 Liganded G12/13-activating GPCRs bind inactive heterotrimeric G-protein G12/13 R-HSA-114552 G12/13 activation by PAR R-HSA-751029 Liganded G12/13-activating GPCR acts as a GEF for G12/13 R-HSA-416482 G alpha (12/13) signalling events R-HSA-456926 Thrombin signalling through proteinase activated receptors (PARs) R-HSA-388396 GPCR downstream signalling R-HSA-76002 Platelet activation, signaling and aggregation R-HSA-372790 Signaling by GPCR R-HSA-109582 Hemostasis R-HSA-162582 Signal Transduction
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
