ID:GNA13_HUMAN DESCRIPTION: RecName: Full=Guanine nucleotide-binding protein subunit alpha-13; Short=G alpha-13; Short=G-protein subunit alpha-13; FUNCTION: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. SUBUNIT: G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site. Interacts with UBXD5. Interacts with HAX1. INTERACTION: Q92888:ARHGEF1; NbExp=2; IntAct=EBI-465387, EBI-465400; SUBCELLULAR LOCATION: Membrane; Lipid-anchor. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. PTM: Palmitoylation is critical for proper membrane localization and signaling. PTM: Phosphorylation on Thr-203 by PKA destabilizes the heterotrimer of alpha, beta and gamma, and inhibits Rho activation. SIMILARITY: Belongs to the G-alpha family. G(12) subfamily.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q14344
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0001525 angiogenesis GO:0001569 branching involved in blood vessel morphogenesis GO:0001701 in utero embryonic development GO:0007165 signal transduction GO:0007186 G-protein coupled receptor signaling pathway GO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway GO:0007204 positive regulation of cytosolic calcium ion concentration GO:0007266 Rho protein signal transduction GO:0008360 regulation of cell shape GO:0030154 cell differentiation GO:0030168 platelet activation GO:0030334 regulation of cell migration GO:0031584 activation of phospholipase D activity GO:0035556 intracellular signal transduction GO:0043065 positive regulation of apoptotic process GO:0051056 regulation of small GTPase mediated signal transduction
BC036756 - Homo sapiens guanine nucleotide binding protein (G protein), alpha 13, mRNA (cDNA clone MGC:46138 IMAGE:5548632), complete cds. AK302400 - Homo sapiens cDNA FLJ50732 complete cds, highly similar to Guanine nucleotide-binding protein alpha-13 subunit. L22075 - Homo sapiens guanine nucleotide regulatory protein (G13) mRNA, complete cds. AK301699 - Homo sapiens cDNA FLJ53108 complete cds, highly similar to Guanine nucleotide-binding protein alpha-13 subunit. KJ893108 - Synthetic construct Homo sapiens clone ccsbBroadEn_02502 GNA13 gene, encodes complete protein. AF493902 - Homo sapiens guanine nucleotide binding protein alpha 13 (GNA13) mRNA, complete cds. AK313672 - Homo sapiens cDNA, FLJ94257, Homo sapiens guanine nucleotide binding protein (G protein), alpha 13 (GNA13), mRNA. DQ893572 - Synthetic construct clone IMAGE:100006202; FLH170527.01X; RZPDo839G0498D guanine nucleotide binding protein (G protein), alpha 13 (GNA13) gene, encodes complete protein. DQ894448 - Synthetic construct Homo sapiens clone IMAGE:100008908; FLH170523.01L; RZPDo839G0497D guanine nucleotide binding protein (G protein), alpha 13 (GNA13) gene, encodes complete protein. AB528470 - Synthetic construct DNA, clone: pF1KB6581, Homo sapiens GNA13 gene for guanine nucleotide binding protein (G protein), alpha 13, without stop codon, in Flexi system. CU691408 - Synthetic construct Homo sapiens gateway clone IMAGE:100019142 5' read GNA13 mRNA. BX647930 - Homo sapiens mRNA; cDNA DKFZp686I20201 (from clone DKFZp686I20201). AB075500 - Homo sapiens neuroblastoma cDNA, clone:Nbla00250, full insert sequence. AK026902 - Homo sapiens cDNA: FLJ23249 fis, clone COL04196. JD047339 - Sequence 28363 from Patent EP1572962. JD496304 - Sequence 477328 from Patent EP1572962. JD183462 - Sequence 164486 from Patent EP1572962. JD516065 - Sequence 497089 from Patent EP1572962. JD254402 - Sequence 235426 from Patent EP1572962. JD227134 - Sequence 208158 from Patent EP1572962. JD284885 - Sequence 265909 from Patent EP1572962. AK002117 - Homo sapiens cDNA FLJ11255 fis, clone PLACE1008902. JD166318 - Sequence 147342 from Patent EP1572962. JD285732 - Sequence 266756 from Patent EP1572962. JD530952 - Sequence 511976 from Patent EP1572962. JD551823 - Sequence 532847 from Patent EP1572962. JD508901 - Sequence 489925 from Patent EP1572962. JD079241 - Sequence 60265 from Patent EP1572962. JD338517 - Sequence 319541 from Patent EP1572962. JD349494 - Sequence 330518 from Patent EP1572962. JD510730 - Sequence 491754 from Patent EP1572962. JD168094 - Sequence 149118 from Patent EP1572962. JD231678 - Sequence 212702 from Patent EP1572962. JD559735 - Sequence 540759 from Patent EP1572962. JD355503 - Sequence 336527 from Patent EP1572962. JD348325 - Sequence 329349 from Patent EP1572962. JD303297 - Sequence 284321 from Patent EP1572962. JD551492 - Sequence 532516 from Patent EP1572962. JD385358 - Sequence 366382 from Patent EP1572962. JD265223 - Sequence 246247 from Patent EP1572962. JD411326 - Sequence 392350 from Patent EP1572962. JD196953 - Sequence 177977 from Patent EP1572962.
Biochemical and Signaling Pathways
BioCarta from NCI Cancer Genome Anatomy Project h_myosinPathway - PKC-catalyzed phosphorylation of inhibitory phosphoprotein of myosin phosphatase h_Par1Pathway - Thrombin signaling and protease-activated receptors
Reactome (by CSHL, EBI, and GO)
Protein Q14344 (Reactome details) participates in the following event(s):
R-HSA-114548 G alpha (13) activates Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) R-HSA-428918 Dissociation of the TP:G13 complex R-HSA-398184 LARG activation by G alpha 12/13 R-HSA-418574 G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP R-HSA-397891 Dissociation of the PAR:G12/13 complex R-HSA-751019 The Ligand:GPCR:G12/13 complex dissociates R-HSA-428909 Activated TP receptor binds G-protein G13 R-HSA-751039 Inactive G alpha (12/13) reassociates with G beta:gamma R-HSA-114544 p115-RhoGEF activation of Rac1 R-HSA-428917 G13 activation by TP receptor R-HSA-398185 LARG binds plexin B1 R-HSA-396941 Thrombin-activated PAR binds G-protein G12/13 R-HSA-751027 Liganded G12/13-activating GPCRs bind inactive heterotrimeric G-protein G12/13 R-HSA-194913 GEFs activate Rho GTPase:GDP R-HSA-419166 GEFs activate RhoA,B,C R-HSA-205039 p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor R-HSA-114552 G12/13 activation by PAR R-HSA-751029 Liganded G12/13-activating GPCR acts as a GEF for G12/13 R-HSA-416482 G alpha (12/13) signalling events R-HSA-428930 Thromboxane signalling through TP receptor R-HSA-456926 Thrombin signalling through proteinase activated receptors (PARs) R-HSA-388396 GPCR downstream signalling R-HSA-392518 Signal amplification R-HSA-76002 Platelet activation, signaling and aggregation R-HSA-372790 Signaling by GPCR R-HSA-194840 Rho GTPase cycle R-HSA-193648 NRAGE signals death through JNK R-HSA-109582 Hemostasis R-HSA-162582 Signal Transduction R-HSA-194315 Signaling by Rho GTPases R-HSA-204998 Cell death signalling via NRAGE, NRIF and NADE R-HSA-193704 p75 NTR receptor-mediated signalling R-HSA-73887 Death Receptor Signalling
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
